Tag: 197.6614

The benzofuran series was written by Villere, G.;Grinsteins, V.. And the article was included in Latvijas Valsts Univ. Ki̅m. Fak. Zina̅tniskie Raksti in 1958.Reference of 3710-47-2 This article mentions the following:

(R in this abstract = isonicotinoyl.) 3-Oxo-2,3-dihydrobenzofuran (I) refluxed 5 hrs. with RNHNH₂ (II) and the unreacted material extracted from the mixture with Et₂O left the hydrazone, m. 187-8°. Similar treatment of I with NCCH₂CONHNH₂ (III) did not give the corresponding compound, even under pressure, and I could also not be condensed in this way with H₂NCSNHNH₂ (IV). 2-Acetylbenzofuran (V), however, could be condensed with II to the hydrazone, m. 229-30°, and III and V refluxed 5 hrs. in EtOH gave the yellowish hydrazone, m. 195-6°. If the pressure was increased so the mixture reached 140°, V and IV condensed to the thiosemicarbazone, m. 190-4°. Similarly, 3-amino-2,3-dihydrobenzofuran-HCl and NCNH₂ (VI) heated 6 hrs. at 150° in EtOH in a sealed ampul and CO₂ passed through the mixture gave 3-guanidino-2,3-dihydrobenzofuran carbonate, m. 150-1°. V, EtOH, AcOH, and NaHg at 40-50° gave 1-(2-benzofuryl)ethylamine-HCl (VII), m. 159-62°. VI and VII heated 8 hrs. in EtOH, and the mixture treated with NaOH then CO₂ yielded [1-(2-benzofuryl)ethyl]guanidine carbonate, m. 102-18° (decomposition). In the experiment, the researchers used many compounds, for example, 1-(1-Benzofuran-2-yl)-1-ethanamine hydrochloride (cas: 3710-47-2Reference of 3710-47-2).

1-(1-Benzofuran-2-yl)-1-ethanamine hydrochloride (cas: 3710-47-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 3710-47-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The benzofuran series was written by Villere, G.;Grinsteins, V.. And the article was included in Latvijas Valsts Univ. Ki̅m. Fak. Zina̅tniskie Raksti in 1958.Reference of 3710-47-2 This article mentions the following:

(R in this abstract = isonicotinoyl.) 3-Oxo-2,3-dihydrobenzofuran (I) refluxed 5 hrs. with RNHNH₂ (II) and the unreacted material extracted from the mixture with Et₂O left the hydrazone, m. 187-8°. Similar treatment of I with NCCH₂CONHNH₂ (III) did not give the corresponding compound, even under pressure, and I could also not be condensed in this way with H₂NCSNHNH₂ (IV). 2-Acetylbenzofuran (V), however, could be condensed with II to the hydrazone, m. 229-30°, and III and V refluxed 5 hrs. in EtOH gave the yellowish hydrazone, m. 195-6°. If the pressure was increased so the mixture reached 140°, V and IV condensed to the thiosemicarbazone, m. 190-4°. Similarly, 3-amino-2,3-dihydrobenzofuran-HCl and NCNH₂ (VI) heated 6 hrs. at 150° in EtOH in a sealed ampul and CO₂ passed through the mixture gave 3-guanidino-2,3-dihydrobenzofuran carbonate, m. 150-1°. V, EtOH, AcOH, and NaHg at 40-50° gave 1-(2-benzofuryl)ethylamine-HCl (VII), m. 159-62°. VI and VII heated 8 hrs. in EtOH, and the mixture treated with NaOH then CO₂ yielded [1-(2-benzofuryl)ethyl]guanidine carbonate, m. 102-18° (decomposition). In the experiment, the researchers used many compounds, for example, 1-(1-Benzofuran-2-yl)-1-ethanamine hydrochloride (cas: 3710-47-2Reference of 3710-47-2).

1-(1-Benzofuran-2-yl)-1-ethanamine hydrochloride (cas: 3710-47-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 3710-47-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem