Tag: 163.1302

Quillardet, Philippe et al. published their research in Biochimie in 1982 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C8H5NO3

The SOS chromotest: direct assay of the expression of gene sfiA as a measure of genotoxicity of chemicals was written by Quillardet, Philippe;Huisman, Olivier;D’Ari, Richard;Hofnung, Maurice. And the article was included in Biochimie in 1982.COA of Formula: C8H5NO3 This article mentions the following:

A gene fusion, placing the lacZ gene encoding β-galactosidase under the control of the sfiA promoter, was used to construct a new tester strain for genotoxic agents. The assay is performed in a few hours and involves simple enzymic assays. The dose-response curves contain a linear portion which allows the SOS Inducing Potency (SOSIP) of compounds to be defined. For the compounds tested, SOSIPs extend over 7 decades and correlate generally well with the mutagenic potency assayed in the Salmonella/microsome assay (Mutatest) and in a phage induction assay (Inductest). Sensitivities (lowest amount detected) are comparable in the SOS Chromotest and Mutatest but lower in the Inductest. Apparently, at least part of the response in the Mutatest depends on the induction of an SOS function, and most of the genotoxins are inducers of the SOS system, i.e., can lead to activation of the RecA protease. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5COA of Formula: C8H5NO3).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C8H5NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Della Rosa, Claudia D. et al. published their research in Tetrahedron Letters in 2011 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 2-Nitrobenzofuran

Diels-Alder reactions of nitrobenzofurans: a simple dibenzofuran Synthesis. Theoretical studies using DFT methods was written by Della Rosa, Claudia D.;Sanchez, Juan P.;Kneeteman, Maria N.;Mancini, Pedro M. E.. And the article was included in Tetrahedron Letters in 2011.Application In Synthesis of 2-Nitrobenzofuran This article mentions the following:

2- and 3-nitrobenzofurans are studied in polar thermal Diels-Alder reactions with normal electron demand using several structurally different dienes. A very strong electron-acceptor group, such as the nitro group, pushes the dienophilic character of these heterocyclic compounds Since this substituent is easily extruded under thermal conditions, this reaction sequence becomes a simple method for the preparation of families of organic compounds with heteroatom rings. Part of this work is specifically concerned with theor. studies using DFT methods. The global and local electrophilicity and nucleophilicity indexes were calculated for the dienophiles and dienes used in this study. When 2-nitrobenzofuran and 3-nitrobenzofuran were reacted with isoprene, 1-trimethylsilyloxy-1,3-butadiene and Danishefsky’s diene, under different thermal reaction conditions they showed their dienophilic character taking part in normal-demand polar DA cycloaddition reactions. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Application In Synthesis of 2-Nitrobenzofuran).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 2-Nitrobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Della Rosa, Claudia D. et al. published their research in Tetrahedron Letters in 2011 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 2-Nitrobenzofuran

Diels-Alder reactions of nitrobenzofurans: a simple dibenzofuran Synthesis. Theoretical studies using DFT methods was written by Della Rosa, Claudia D.;Sanchez, Juan P.;Kneeteman, Maria N.;Mancini, Pedro M. E.. And the article was included in Tetrahedron Letters in 2011.Application In Synthesis of 2-Nitrobenzofuran This article mentions the following:

2- and 3-nitrobenzofurans are studied in polar thermal Diels-Alder reactions with normal electron demand using several structurally different dienes. A very strong electron-acceptor group, such as the nitro group, pushes the dienophilic character of these heterocyclic compounds Since this substituent is easily extruded under thermal conditions, this reaction sequence becomes a simple method for the preparation of families of organic compounds with heteroatom rings. Part of this work is specifically concerned with theor. studies using DFT methods. The global and local electrophilicity and nucleophilicity indexes were calculated for the dienophiles and dienes used in this study. When 2-nitrobenzofuran and 3-nitrobenzofuran were reacted with isoprene, 1-trimethylsilyloxy-1,3-butadiene and Danishefsky’s diene, under different thermal reaction conditions they showed their dienophilic character taking part in normal-demand polar DA cycloaddition reactions. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Application In Synthesis of 2-Nitrobenzofuran).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 2-Nitrobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Hongkui et al. published their research in Angewandte Chemie, International Edition in 2021 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 2-Nitrobenzofuran

Regio- and Stereoselective Cascade of β,γ-Unsaturated Ketones by Dipeptided Phosphonium Salt Catalysis: Stereospecific Construction of Dihydrofuro-Fused [2,3-b] Skeletons was written by Zhang, Hongkui;He, Jiajia;Chen, Yayun;Zhuang, Cheng;Jiang, Chunhui;Xiao, Kai;Su, Zhishan;Ren, Xiaoyu;Wang, Tianli. And the article was included in Angewandte Chemie, International Edition in 2021.Safety of 2-Nitrobenzofuran This article mentions the following:

Chiral (dihydro)furo-fused heterocycles are significant structural motifs in numerous natural products, functional materials and pharmaceuticals. Therefore, developing efficient methods for preparing compounds with these privileged scaffolds is an important endeavor in synthetic chem. Herein, we develop an effective, modular method by a dipeptide-phosphonium salt-catalyzed regio- and stereoselective cascade reaction of readily available linear β,γ-unsaturated ketones with aromatic alkenes, affording a wide variety of structurally fused heterocyclic mols., e.g., I, in high yields with excellent stereoselectivities. Moreover, mechanistic investigations revealed that the bifunctional phosphonium salt controlled the regio- and stereoselectivities of this cascade reaction, particularly proceeding through the initial ketone α-addition followed by O-participated substitution; and the multiple hydrogen-bonding interactions between Broensted acid moieties of catalyst and nitro group of aromatic alkene were crucial in asym. induction. Given the generality, versatility, and high efficiency of this method, we anticipate that it will have broad synthetic utilities. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Safety of 2-Nitrobenzofuran).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 2-Nitrobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Lythgoe, David J. et al. published their research in Journal of Heterocyclic Chemistry in 1993 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C8H5NO3

A study of 2-aminofurans was written by Lythgoe, David J.;McClenaghan, Ian;Ramsden, Christopher A.. And the article was included in Journal of Heterocyclic Chemistry in 1993.COA of Formula: C8H5NO3 This article mentions the following:

Catalytic reduction of 2-nitrofurans, e.g., I, gives low yields of 2-aminofurans 1 which are not isolated but are trapped using Et ethoxymethylenecyanoacetate (6) or ethoxymethylenemalononitrile (7). In these reactions 2-aminofuran (1a) behaves like a dieneamine with substitution occurring at position 5 of the ring. When the 5-position is substituted reaction takes place at position 3 and thermal cyclization of the product gives furo[2,3-b]pyridine derivatives, e.g., II. An AM1 calculation of the properties of 2-aminofuran (1a) is reported and the results are consistent with observed properties. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5COA of Formula: C8H5NO3).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C8H5NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dyguda, Mateusz et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Computed Properties of C8H5NO3

Dearomative Michael addition involving enals and 2-nitrobenzofurans realized under NHC-catalysis was written by Dyguda, Mateusz;Skrzynska, Anna;Sieron, Leslaw;Albrecht, Lukasz. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Computed Properties of C8H5NO3 This article mentions the following:

The first enantioselective dearomative Michael addition between α,β-unsaturated aldehydes and 2-nitrobenzofurans under N-heterocyclic carbene activation was described. The reaction proceeded via addition of homoenolate to Michael acceptors leading to the formation of biol. important heterocycles such as I [Ar = Ph, 3-anisyl, 2-furyl, etc.] with high yields and stereoselectivities. Their functionalization potential was confirmed in selected, diastereoselective transformations. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Computed Properties of C8H5NO3).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Computed Properties of C8H5NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Lythgoe, David J. et al. published their research in Journal of Heterocyclic Chemistry in 1993 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C8H5NO3

A study of 2-aminofurans was written by Lythgoe, David J.;McClenaghan, Ian;Ramsden, Christopher A.. And the article was included in Journal of Heterocyclic Chemistry in 1993.COA of Formula: C8H5NO3 This article mentions the following:

Catalytic reduction of 2-nitrofurans, e.g., I, gives low yields of 2-aminofurans 1 which are not isolated but are trapped using Et ethoxymethylenecyanoacetate (6) or ethoxymethylenemalononitrile (7). In these reactions 2-aminofuran (1a) behaves like a dieneamine with substitution occurring at position 5 of the ring. When the 5-position is substituted reaction takes place at position 3 and thermal cyclization of the product gives furo[2,3-b]pyridine derivatives, e.g., II. An AM1 calculation of the properties of 2-aminofuran (1a) is reported and the results are consistent with observed properties. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5COA of Formula: C8H5NO3).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C8H5NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dyguda, Mateusz et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 33094-66-5

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Computed Properties of C8H5NO3

Dearomative Michael addition involving enals and 2-nitrobenzofurans realized under NHC-catalysis was written by Dyguda, Mateusz;Skrzynska, Anna;Sieron, Leslaw;Albrecht, Lukasz. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Computed Properties of C8H5NO3 This article mentions the following:

The first enantioselective dearomative Michael addition between α,β-unsaturated aldehydes and 2-nitrobenzofurans under N-heterocyclic carbene activation was described. The reaction proceeded via addition of homoenolate to Michael acceptors leading to the formation of biol. important heterocycles such as I [Ar = Ph, 3-anisyl, 2-furyl, etc.] with high yields and stereoselectivities. Their functionalization potential was confirmed in selected, diastereoselective transformations. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Computed Properties of C8H5NO3).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Computed Properties of C8H5NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem