Tag: 100-200

Hydrophobicity parameters determined by reversed-phase liquid chromatography. VIII. Hydrogen-bond effects of ester and amide groups in heteroaromatic compounds on the relationship between the capacity factor and the octanol-water partition coefficient was written by Yamagami, Chisako;Yokota, Miho;Takao, Narao. And the article was included in Journal of Chromatography A in 1994.Category: benzofurans This article mentions the following:

The logarithms of the capacity factors, log k’, for several heteroaromatic systems (furan, pyrrole, benzofuran, indole, benzene and their alkyl, ester and amide derivatives) were determined on a Capcell Pak C₁₈ column using methanol-buffer (pH 7.4) mobile phases of different compositions These results and the log k_w values, derived by a linear extrapolation of the plot of log k’ against the volume fraction of methanol to 0% methanol, were correlated with exptl. log P values by taking into account the hydrogen-acceptor and hydrogen-donor effects. Whereas the hydrogen-donor effect is minimized by using the log k_w parameter, the hydrogen-acceptor effect was found to become insignificant in an eluent containing 50% methanol. Isocratic data determined at this eluent composition gave the simplest and best correlation. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Category: benzofurans).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease was written by Buckley, Benjamin J.;Majed, Hiwa;Aboelela, Ashraf;Minaei, Elahe;Jiang, Longguang;Fildes, Karen;Cheung, Chen-Yi;Johnson, Darren;Bachovchin, Daniel;Cook, Gregory M.;Huang, Mingdong;Ranson, Marie;Kelso, Michael J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Safety of (5-Methoxybenzofuran-2-yl)boronic acid This article mentions the following:

Aryldiaminopyrazinecarbonyl guanidines I (R = Ph, 4-MeSC₆H₄, 4-F₃CC₆H₄, 5-pyrimidinyl, 2,4-dimethoxy-5-pyrimidinyl, 2-methoxy-5-pyrimidinyl, 2,6-dimethoxy-3-pyridinyl, 2-thienyl, 2-furanyl, 3-furanyl, 1-methyl-4-pyrazolyl, 2-benzothienyl, 5-R¹-2-benzofuranyl, 6-methoxy-2-benzofuranyl, 2,3-dihydro-5-benzofuranyl; R¹ = H, Me, MeO, F, Cl, Br, NC) were prepared as analogs of the potassium ion-sparing diuretic amiloride for the inhibition of urokinase-type plasminogen activator (uPA) and for inhibiting tumor metastasis. The structures of four aryldiaminopyrazinecarbonyl guanidines bound to uPA were determined by X-ray crystallog.; the improved inhibition of uPA by amiloride analogs likely arise from increased occupancy of uPA’s S1β subsite by the aryl substituents. I (R = 2-benzofuranyl, 2-methoxy-5-pyrimidinyl) were selective for uPA over related trypsin-like serine proteases and did not show diuretic or anti-kaliuretic effects in rats. I (R = 2-benzofuranyl) inhibited tumor metastasis in a murine xenograft lung cancer model. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Safety of (5-Methoxybenzofuran-2-yl)boronic acid).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Safety of (5-Methoxybenzofuran-2-yl)boronic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Studies in benzofurans. Part XII. Synthesis and reactions of 2-chloromethyl-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidine was written by Vaidya, V. P.;Agasimundin, Y. S.. And the article was included in Indian Journal of Chemistry in 1981.Related Products of 54802-10-7 This article mentions the following:

The benzofuropyrimidinones I (R = Cl, OH) were prepared by the cyclization of II. I (R = OH) was treated with POCl₃ to give the (chloromethyl)benzofuropyrimidine III. I (R = Cl) and III underwent nucleophilic substitution with amines and alcs. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation of α-aminophosphines on solid support: model studies and parallel synthesis was written by Bar-Nir Ben-Aroya, B.;Portnoy, Moshe. And the article was included in Tetrahedron in 2002.Formula: C10H8O3 This article mentions the following:

On-resin assembly of phosphine ligands represents a formidable challenge. Following model solution studies, the authors developed two synthetic routes for α-aminophosphine synthesis on solid support. The ligands were prepared via the Mannich reaction of the resin-bound aldehyde, amine and diphenylphosphine with very good yield and purity. Alternatively, the amine can serve as the anchoring building block. The ligands were qual. and quant. analyzed using gel-phase ³¹P and ¹³C NMR techniques. The studies culminated in the parallel synthesis of a 40-member library of borane-protected α-aminophosphines. For example, use of 4-formylbenzoic acid and 2-methylaniline gave 100% resin-bound -CH₂O₂CC₆H₄CH(NHC₆H₄Me-o)PPh₂-p·BH₃. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Studies in benzofurans: Part I. Synthesis of some benzofuro[3,2-d]pyrimidine derivatives was written by Sangapure, S. S.;Agasimundin, Y. S.. And the article was included in Indian Journal of Chemistry in 1976.Application of 54802-10-7 This article mentions the following:

O-HOC6H4CN was condensed with BrCH2CO2Et, ClCH2CONH2, ClCH2CN, resp., to give o-NC = C6H4OCH2R (R = CO2Et, CONH2, CN), which underwent Thorpe-Ziegler cyclization to give the corresponding benzofuran derivatives I in good yields. I served as intermediates for the synthesis of various benzofuro[3,2-d]pyrimidine derivatives II, III, and IV (R = NH2). III was converted into IV (R = Cl) which on further displacement reactions gives IV (R = MeS, EtS, PhCH2S, MeO, EtO). In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The infrared vibration bands of CH in solid CHCl₃ and CDCl₃ was written by Denariez, Marguerite Marie. And the article was included in Journal de Chimie Physique et de Physico-Chimie Biologique in 1965.Safety of Methyl benzofuran-2-carboxylate This article mentions the following:

Disagreement in previous reports on the C-H band in CHCl₃ (I) (Lisitsa and Tsyashchenko, CA 55, 15118e; Maklakov and Nikitin, CA 60, 7589c; Ito, CA 61, 9068b) are herein ascribed to two crystalline forms of solid I. By using the cryostat of Becker & Pimental (CA 50, 15244a), evaporation onto KBr or CsBr plates at 80 or 150°K. gives 2 different spectra; warming the 80°K. sample causes the spectrum to shift while the reverse (cooling) has no effect. The spectrum of the higher form is related to that in solution and is regarded as that of the stable form. CDCl₃ behaves like I. The change is due to increased degeneracy of vibration levels enhanced by resonance between neighboring mols. in the solid. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Safety of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Safety of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions was written by Wang, Xiu;Wang, Zhenhua;Ishida, Takumi;Nishihara, Yasushi. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:

Aryl fluorides (prepared from the corresponding aryl chlorides) underwent methoxylation reactions with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) (in the absence of added metal catalysts or reagents) in toluene to yield Me esters. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Continuous-Flow Synthesis of Perfluoroalkyl Ketones via Perfluoroalkylation of Esters Using HFC-23 and HFC-125 under a KHMDS-Triglyme System was written by Fujihira, Yamato;Iwasaki, Hiroto;Sumii, Yuji;Adachi, Hiroaki;Kagawa, Takumi;Shibata, Norio. And the article was included in Bulletin of the Chemical Society of Japan in 2022.Recommanded Product: 1646-27-1 This article mentions the following:

Herein, a method for the chem. transformation of two HFCs, viz was described. HFC-23 and HFC-125, based on the continuous-flow perfluoroalkylation of esters to synthesize the pharmaceutically and agrochem. vital trifluoromethyl and pentafluoroethyl ketones. The combination of a potassium base and a glyme solvent system was found to be the most effective. The proposed method was attractive for industrial use because it allows the consumption of a large volume of HFCs, promotes the synthesis of high-value medicinal compounds, and serves as an ideal alternative to the current HFC decomposition processes like thermal plasma treatment. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

PPh₃-assisted esterification of acyl fluorides with ethers via C(sp₃)-O bond cleavage accelerated by TBAT was written by Wang, Zhenhua;Wang, Xiu;Nishihara, Yasushi. And the article was included in Catalysts in 2019.Related Products of 1646-27-1 This article mentions the following:

The triphenylphosphine (PPh₃)-assisted methoxylation of acyl fluorides with cyclopentyl Me ether (CPME) accelerated by tetrabutylammonium difluorotriphenysilicate (TBAT) via regiospecific C-OMe bond cleavage was described. CPME was utilized not only as the solvent, but also as methoxylating agent. The reported method was featured by C-O and C-F bond cleavage under metal-free conditions, good functional-group tolerance and wide substrate scope. Mechanistic studies revealed that the radical process was not involved. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Related Products of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem