Tag: 100-200

Synthesis of blue-red emissive amido-substituted di(het)aryl and tri(het)aryl amine derivatives via chemoselective N-mono and N,N-diarylation of (het) aryl amino amides using benzyne/arynes was written by Meerakrishna, Ramakrishnan Suseela;Shanmugam, Ponnusamy. And the article was included in New Journal of Chemistry in 2019.Quality Control of 3-Aminobenzofuran-2-carboxamide This article mentions the following:

N-mono- and N,N-chemoselective diarylation of an aryl/hetaryl amino amide reaction using benzyne or arynes, an amide-substituted triaryl amine derivative and diaryl amine derivatives were afforded. The scope and limitation of the present study was studied. The products thus obtained were synthetically transformed to highly functionalized biphenyl bridged heterocycles via Suzuki coupling and condensation with 4,4′-biphenyl dialdehyde. Evaluation of the photophys. properties revealed that the triaryl amine derivatives were blue emissive with high quantum yields, whereas the heterocyclic triaryl amine derivatives were blue-red emissive. 3-(Diphenylamino)benzofuran-2-carboxamide was found to be blue emissive with high quantum yield, whereas the 2-(diphenylamino)nicotinamide was found to be red emissive with low quantum yield. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Quality Control of 3-Aminobenzofuran-2-carboxamide).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Quality Control of 3-Aminobenzofuran-2-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Phosphotungstic acid mediated, microwave assisted solvent-free green synthesis of highly functionalized 2′-spiro and 2, 3-dihydro quinazolinone and 2-methylamino benzamide derivatives from aryl and heteroaryl 2-amino amides was written by Novanna, Motakatla;Kannadasan, Sathananthan;Shanmugam, Ponnusamy. And the article was included in Tetrahedron Letters in 2019.Related Products of 54802-10-7 This article mentions the following:

Phosphotungstic acid has been found as green catalyst for the synthesis of spiro and cyclized quinazolinones and 2-amino substituted carboxamide under microwave irradiation and solvent-free condition. The scope of the reaction has been demonstrated for a variety of aldehydes and ketones with o-amino amides such as 2-aminobenzamide, 2-amino-5-iodobenzamide, 3-aminothiophene-2-carboxamide, 3-aminobenzofuran-2-carboxamide and 2-aminopyridine-3-carboxamide. The reaction afforded spiro-, cyclized quinazolinones and 2-amino substituted carboxamide derivatives within few minutes of irradiation in excellent yield. Plausible mechanism for the formation of products is provided. Synthetic utility of 1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one 3a (I) has been demonstrated by synthesis of 1,4-di(1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one) buta-1,3-diyne 12 (II), 1′-((1-benzyl-1H-1,2,3-triazol-4-yl) methyl)-1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one 13 (III) and 1′-phenyl-1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one 14 (IV) under standard protocols. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rhodium-Catalyzed Intermolecular Cyclopropanation of Benzofurans, Indoles, and Alkenes via Cyclopropene Ring Opening was written by Ross, Rachel J.;Jeyaseelan, Rubaishan;Lautens, Mark. And the article was included in Organic Letters in 2020.Application of 1646-27-1 This article mentions the following:

The generation of metal carbenoids via ring opening of cyclopropenes by transition metals offers a simple entry into highly reactive intermediates. Herein, we describe a diastereoselective intermol. rhodium-catalyzed cyclopropanation of heterocycles and alkenes using cyclopropenes as carbene precursors with a low loading of a com. available rhodium catalyst. The reported method is scalable and could be performed with catalyst loadings as low as 0.2 mol %, with no impact to the reaction yield or selectivity. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of euparin and dehydrotremetone was written by Ramachandran, P. K.;Chang, T.;Horton, W. J.. And the article was included in Tetrahedron Letters in 1963.Application In Synthesis of Methyl benzofuran-2-carboxylate This article mentions the following:

Me 5-acetyl-6-acetoxycoumarilate ketalized with (CH₂OH)₂ with the loss of the O-Ac group, and the product treated with excess MeMgI and chromatographed on Al₂O₃ yielded euparin (I), m. 121-2°; semicarbazone m. 254-5°; dinitrophenylhydrazone m. 254-5°; maleic anhydride adduct m. 244-5°. I gives a green color with FeCl₃ and an orange to red, brown, and then green color with concentrated H₂SO₄. Me coumarilate (II) acetylated in the presence – of AlCl₃ yielded the 5-Ac derivative (III) of II, the oxime of which was converted by a Bechmann rearrangement to the 5-NH₂ derivative (IV) of II. IV was then converted to the 5-Cl derivative of II, m. 94-6°. The catalytic reduction of III yielded the 5-Et derivative of II. The ethylene glycol ketal of III treated with MeMgI, and the resulting tertiary alc. dehydrated and cleaved by acid yielded dehydrotremetone (V), m. 84.0-5.5°; oxime m. 131.53.5°; maleic anhydride adduct m. 205-10°. The synthetic V was identical with V from Aplopappus heterophyllus and from Eupatorium urticaefolium. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application In Synthesis of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application In Synthesis of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity was written by Oderinde, Martins S.;Ramirez, Antonio;Dhar, T. G. Murali;Cornelius, Lyndon A. M.;Jorge, Christine;Aulakh, Darpandeep;Sandhu, Bhupinder;Pawluczyk, Joseph;Sarjeant, Amy A.;Meanwell, Nicholas A.;Mathur, Arvind;Kempson, James. And the article was included in Journal of Organic Chemistry in 2021.HPLC of Formula: 1646-27-1 This article mentions the following:

Indole and indoline rings are important pharmacophoric scaffolds found in marketed drugs, agrochems., and biol. active mols. The [2 + 2] cycloaddition reaction is a versatile strategy for constructing architecturally interesting, sp³-rich cyclobutane-fused scaffolds with potential applications in drug discovery programs. A general platform for visible-light mediated intermol. [2 + 2] cycloaddition of indoles with alkenes has been realized. A substrate-based screening approach led to the discovery of tert-butyloxycarbonyl (Boc)-protected indole-2-carboxyesters as suitable motifs for the intermol. [2 + 2] cycloaddition reaction. Significantly, the reaction proceeds in good yield with a wide variety of both activated and unactivated alkenes, including those containing free amines and alcs., and the transformation exhibits excellent regio- and diastereoselectivity. Moreover, the scope of the indole substrate is very broad, extending to previously unexplored azaindole heterocycles that collectively afford fused cyclobutane containing scaffolds that offer unique properties with functional handles and vectors suitable for further derivatization. DFT computational studies provide insights into the mechanism of this [2 + 2] cycloaddition, which is initiated by a triplet-triplet energy transfer process. The photocatalytic reaction was successfully performed on a 100 g scale to provide the dihydroindole analog. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1HPLC of Formula: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.HPLC of Formula: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ketocoumarins. A new class of triplet sensitizers was written by Specht, Donald P.;Martic, Peter A.;Farid, Samir. And the article was included in Tetrahedron in 1982.Product Details of 1646-27-1 This article mentions the following:

Derivatives of 3-ketocoumarins, e.g. I and II, were prepared by standard methods and showed the photophys. criteria of efficient triplet sensitizers. The ketocoumarins, with absorption maximum at 330-450 nm, have extinction coefficients of 10⁴-10⁵, which is an important criterion for efficient sensitization of thin films of polymers in photoresists and lithog. The singlet-triplet intersystem crossing (isc) efficiencies of several derivatives were âˆ?, whereas in others a radiationless decay process competes with the isc, and is dominant in asym. substituted derivatives The triplet energies of the ketocoumarins were 48-60 kcal/mol. The phosphorescence spectra of some ketocoumarins show the presence of “frozen-in” rotamers. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Product Details of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Palladium-catalyzed carbonylative synthesis of quinazolinones from 2-aminobenzamide and aryl bromides was written by Wu, Xiao-Feng;He, Lin;Neumann, Helfried;Beller, Matthias. And the article was included in Chemistry – A European Journal in 2013.Application of 54802-10-7 This article mentions the following:

A straightforward procedure for the carbonylative synthesis of quinazolinones from readily available 2-aminobenzamides and bromobenzenes was developed. Various quinazolinones were produced in moderate to excellent yields under identical reaction conditions. Remarkably, all of the products were purified by simple filtration or recrystallization, and no chromatog. was needed. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and antimicrobial activities of some new benzofuro[3,2-d]pyrimidines was written by Basawaraj, Raga;Khandre, Omakar;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2011.Application of 54802-10-7 This article mentions the following:

2-(4-Nitrophenyl)-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidine was prepared by cyclocondensation of 3-amino-2-benzofurancarboxamide with 4-nitrobenzaldehyde in presence of catalytic quantity of concentrate hydrochloric acid. The nucleophilic displacement reaction of the above compound with phosphorus oxychloride furnished 4-chloro-2-(4-nitrophenyl)benzofuro[3,2-d]pyrimidine. Benzofuro[3,2-d]pyrimidine derivatives, e.g., I, were prepared by condensation of 4-chloro-2-(4-nitrophenyl)benzofuro[3,2-d]pyrimidine with amines. Synthesized compounds were characterized on the basis of spectral and anal. data. All the compounds were screened for biol. activity. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sequential detection of Fe^3+/2+ and pyrophosphate by a colorimetric chemosensor in a near-perfect aqueous solution was written by Chae, Ju Byeong;Jang, Hyo Jung;Kim, Cheal. And the article was included in Photochemical & Photobiological Sciences in 2017.Application of 54802-10-7 This article mentions the following:

A novel colorimetric chemosensor 1 was designed and synthesized for Fe^3+/2+ and pyrophosphate. Sensor 1 showed a selective color change toward both Fe³⁺ and Fe²⁺ from yellow to brown in a near-perfect aqueous solution The detection limits (0.36 μM and 0.37 μM) for Fe³⁺ and Fe²⁺ were much lower than the guideline (5.37 μM) set by the Environmental Protection Agency (EPA) for iron in drinking water. Sensor 1 could be used to quantify Fe³⁺ in real water samples. Moreover, the resulting Fe³⁺-2·1 complex can detect pyrophosphate selectively over various anions especially including phosphate-based anions through a metal-complex displacement method. Based on UV-vis titrations, Job plot and ESI-mass spectrometry analyses, the sensing mechanisms of Fe³⁺, Fe²⁺ and PPi were proposed. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cobalt Nanoparticles-Catalyzed Widely Applicable Successive C-C Bond Cleavage in Alcohols to Access Esters was written by Luo, Huihui;Wang, Lianyue;Shang, Sensen;Li, Guosong;Lv, Ying;Gao, Shuang;Dai, Wen. And the article was included in Angewandte Chemie, International Edition in 2020.Quality Control of Methyl benzofuran-2-carboxylate This article mentions the following:

Selective cleavage and functionalization of C-C bonds have important applications in organic synthesis and biomass use. However, functionalization of C-C bonds by controlled cleavage remains difficult and challenging because they are inert. Herein, the authors describe an unprecedented efficient protocol for the breaking of successive C-C bonds in alcs. to form esters with one or multiple carbon atoms less using heterogeneous cobalt nanoparticles as catalyst with dioxygen as the oxidant. A wide range of alcs. including inactive long-chain alkyl aryl alcs. undergo smoothly successive cleavage of adjacent -(C-C)_n– bonds to afford the corresponding esters. The catalyst was used for seven times without any decrease in activity. Characterization and control experiments disclose that cobalt nanoparticles are responsible for the successive cleavage of C-C bonds to achieve excellent catalytic activity, while the presence of Co-N_x has just the opposite effect. Preliminary mechanistic studies reveal that a tandem sequence reaction is involved in this process. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Quality Control of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Quality Control of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem