Prospects of Wedelolactone as a Chemotherapeutic Agent in Gynecological Cancers; Clue From its In Vitro and In Silico Investigation was written by Sarwar, Sadia;Amed, Tauqeer;Qazi, Neelum Gul;Yu, Jun Qing;Huq, Fazlul. And the article was included in Current Computer-Aided Drug Design in 2020.Product Details of 524-12-9 The following contents are mentioned in the article:
Aim of this study was to investigate growth inhibitory effect of Wedelolactone (WDL) on estrogen-dependent & independent gynecol. cell lines & to explore its inhibitory potential towards key targets through in silico study. WDL cytotoxicity studies in human breast & ovarian cancer cell lines (MCF-7 and SKOV3) through 3-(4,5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazoloium bromide (MTT) reduction assay. Epigallocatechingallate (EGCG) was used as reference natural compound while cisplatin was taken as a standard clin. agent. Both WDL & EGCG in combination with cisplatin evaluated for their combined growth inhibitory potential in MCF-7 cells. WDL evaluated in silico against key factors including braf kinases, CDPK, ERα, aromatase, topoisomerase II and dihydrofolate reductase (DHFR) playing pivotal roles in driving multiple tumors. Binding energy order ; WDL: DHFR >Braf kinases > CDPK; aromatase > topoisomerase II> ERα > NFkB > alk. phosphatase; EGCG dihydrofolatereductase (DHFR) > aromatase >CDPK > topoisomerase II > braf kinases > alk. phosphatase > CDPK > ERα > NFkB. WDL identified as a cytotoxic agent in breast & ovarian tumor models with potential to inhibit multiple targets in oncogenic pathway including estrogen receptor ERα, as depicted thro’ its in silico study. Further research to be encouraged to see diff. aspects of wedelolactone as an addnl. agent to be combined with antiestrogen or endocrine therapy. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Product Details of 524-12-9).
1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 524-12-9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem