Identification of bioactive constituents in Coldenia procumbens L. and its antidiabetic activity against streptozotocin induced Wistar albino rats was written by Rethinam, Ganesan;Venkatanarasimhan, Mathuram. And the article was included in Journal of Complementary and Integrative Medicine in 2020.Related Products of 524-12-9 The following contents are mentioned in the article:
Type II diabetes, a multifactorial progressive disorder is the prime concern of the twenty-first century. Modern medicine is proven effective in delaying the effects of diabetes. However, the side effects are amplified over time. In order to find relief from side effects, people are rigorously searching for alternative treatment. In this study, we aim to identify the bioactive components in the Coldenia procumbens L. and assess its anti-diabetic effect. Initially, the plant was extracted using chloroform and methanol. Both the extracts were analyzed using IR Spectrum and NMR. The methanol extract of Coldenia procumbens L. was assessed for its anti-hyperglycemic activity against streptozotocin induced animals. The IR spectrum of the extracts was compared with standard compounds and four compounds, α-amyrin, β-sitosterol, β-stigmasterol and wedelolactone was identified. Methanol extract of Coldenia procumbens L. decreased glucose levels in serum and enzymes levels. Histopathol. of pancreas showed excellent recovery from the damage induced by streptozotocin. The compounds identified in Coldenia procumbens L. have significant anti-diabetic, insulin mimetic and insulin secretory activities with their complete mechanisms already studied in detail. Also, Coldenia procumbens L. methanol extract showed significant anti-hyperglycemic activity. The plant should be further studied to be developed as an alternative medicine. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).
1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 524-12-9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem