Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, belongs to benzofurans compound. In a document, author is Leonard, Peter, introduce the new discover, COA of Formula: C10H7NO4.
Nucleobase-Functionalized 5-Aza-7-deazaguanine Ribo- and 2 ‘-Deoxyribonucleosides: Glycosylation, Pd-Assisted Cross-Coupling, and Photophysical Properties
The special nucleobase recognition pattern of S-aza-7-deazaguanine nucleosides makes them valuable for construction of homo purine DNA, silver-mediated base pairs, and expansion of the four letter genetic coding system. To widen the utility of 5-aza-7-deazaguanine nucleosides, side chains were introduced at position-7 of the nucleobase. As key compounds, 7-iodo nucleosides were synthesized. Nucleobase anion glycosylation of the iodo derivative of isobutyrylated S-aza-7-deazaguanine with the bromo sugar of 2,3,S-tri-O-benzoyl-1-O-acetyl-D-ribofuranose gave the pure beta-D anomeric N-9 glycosylation product (67%), whereas one-pot Vorbriiggen conditions gave only 42% of the iodinated nucleoside. The noniodinated nucleoside was formed in 84%. For the synthesis of 2′-deoxyribonucleosides, anion glycosylation performed with Hoffer’s 2′-deoxyhalogenose yielded an anomeric mixture (a-D = 33% and beta-D = 39%) of 2′-deoxyribonucleosides. Various side chain derivatives were prepared from nonprotected nucleosides by Pd-assisted Sonogashira or Suzuki-Miyaura cross-coupling. Among the functionalized ribonucleosides and anomeric 2′-deoxyribonucleosides, some of them showed strong fluorescence. Benzofuran and pyrene derivatives display high quantum yields in non-aqueous solvents and solvatochromism. Single-crystal X-ray analysis of 7-iodo-5-aza-7-deaza-2’-deoxyguanosine displayed intermolecular iodo-oxygen interactions in the crystal and channels filled with solvent molecules.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 6296-53-3. COA of Formula: C10H7NO4.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem