Bio-modified TiO2 nanoparticles with Withania somnifera, Eclipta prostrata and Glycyrrhiza glabra for anticancer and antibacterial applications was written by Maheswari, P.;Harish, S.;Navaneethan, M.;Muthamizhchelvan, C.;Ponnusamy, S.;Hayakawa, Y.. And the article was included in Materials Science & Engineering in 2020.Quality Control of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:
Titanium dioxide nanoparticles exhibit good anticancer and antibacterial activities. They are known to be environmentally friendly and stable, less toxic and excellent biocompatibility nature. In this paper we report the biol. properties of pure TiO2 nanoparticles modified with Withania somnifera (Ashwagandha), Eclipta prostrata (Karisalankanni) and Glycyrrhiza glabra (Athimathuram) for biol. applications. X-ray diffraction results revealed the anatase nature of the samples. From the TEM analyses, it is observed that there is an increase in the particle size of the bio modified samples. UV results show the red shift for the bio modified samples when compared with the pure samples. The samples are then subjected to MTT assay to determine the cell viability. KB oral cancer cells are used for the determination of anticancer nature of the pure and bio modified nanoparticles. It is observed that Withania somnifera – Eclipta prostrate modified TiO2 nanoparticles exhibit excellent anticancer activities among other bio modified and pure samples. The samples are then examined for their antibacterial activities against three Gram-neg. bacterial strains namely, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two Gram-pos. bacterial strains namely, Staphylococcus aureus and Streptococcus mutans. Among the modified and pure samples, Withania somnifera – Eclipta prostrata showed good antibacterial nature against Gram-pos. and Gram-neg. bacteria. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Quality Control of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).
1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Quality Control of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem