Effects of phonophoresis with diclofenac linked gold nanoparticles in model of traumatic muscle injury was written by Haupenthal, Daniela Pacheco dos Santos;Zortea, Diogo;Zaccaron, Rubya Pereira;Silveira, Gustavo de Bem;Correa, Maria Eduarda Anastacio Borges;Mendes, Carolini;Casagrande, Laura de Roch;Duarte, Mariane Bernardo;Pinho, Ricardo Aurino;Feuser, Paulo Emilio;Machado-de-Avila, Ricardo Andrez;Silveira, Paulo Cesar Lock. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020.Application of 76-54-0 This article mentions the following:
Thus, the objective of this study was to investigate the therapeutic effect of phonophoresis using diclofenac (DC) linked to gold nanoparticles (GNPs) in the skeletal muscle of rats used as a model of traumatic muscular injury. Wistar rats were divided into eight groups: Sham, Muscle injury (MI), MI + TPU, MI + DC, MI + GNPs, MI + TPU + DC, MI + TPU + GNPs, and MI + TPU + DC-GNPs. The traumatic injury was performed in the gastrocnemius with a single direct traumatic impact via an injuring press. The animals received daily treatment for 5 consecutive days with TPU and gel with DC and/or GNPs. Two hours after the last treatment session, animals were euthanized and the gastrocnemius muscle surgically removed for histol. and biochem. anal. Reactive species production and protein damage resulting from oxidative damage was lower for the group exposed to all tested therapies had lower production Lower protein damage was also observed in the TPU + GNPs group. The group that underwent all tested therapies combined showed a significant increase in antioxidants compared to the MI group. During histol. anal., the MI group showed large amounts of cell infiltration and centralized nuclei, whereas the MI + TPU + DC-GNPs group showed structural improvements. Pain levels in the MI + TPU + DC-GNPs group were lower than those of the MI group. We believe that the association of TPU with DC linked to GNPs decreases the inflammation caused by traumatic muscle injury and accelerates tissue repair. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application of 76-54-0).
2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 76-54-0
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem