Category: benzofurans. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about The effect of bradykinin and anti-inflammatory agents on isolated arteries. Author is Starr, M. S.; West, Geoffrey Buckle.
All artery preparations (pulmonary, ear, femoral, mesenteric, brachial, and carotid arteries) from guinea pigs were constricted by bradykinin (0.1-10 γ), but only those of the pulmonary vessels of the rat and rabbit responded in this way. The vasoconstrictor action of bradykinin on the isolated mammalian arteries was antagonized by Na phenylbutazone, Na mefenamate, Na flufenamate, Na meclofenamate, and Ca acetylsalicylate when the latter were administered by slow infusion (0.1-2.5 mg./min.) However, the same concentrations of the antagonists also antagonized the vasoconstrictor responses to histamine, 5-hydroxytryptamine, acetylcholine, noradrenaline, and kallidin, thus indicating that the antagonism was nonspecific.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem