A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Gao, Feng,once mentioned of 497-23-4, Application In Synthesis of Furan-2(5H)-one.
Benzofuran-isatin hybrids tethered via different length alkyl linkers and their in vitro anti-mycobacterial activities
A series of novel benzofuran-isatin hybrids 6a-m tethered through different length alkyl linkers propylene, butylene, pentylene and hexylene were designed, synthesized and evaluated for their in vitro anti-mycobacterial activities against both drug-susceptible and multi-drug resistant (MDR) Mycobacterium tuberculosis (MTB) and cytotoxicity towards VERO cells. All hybrids with acceptable cytotoxicity in VERO cells (CC50:64 to>1024 mu g/mL) also exhibited considerable anti-mycobacterial activities against both drug-susceptible and MDR-MTB strains with MIC in a range of 0.125-4 mu g/mL. The SAR indicated that the length of the linker played a pivotal role on the activity, and the longer linker could enhance the activity. The most active hybrid 6d (MIC:0.125 and 0.125 mu g/mL) was comparable to or better than rifampicin (MIC:0.5 mu g/mL) and isoniazid (MIC:0.06 mu g/mL) against MTB H(37)Rv, and was >256 folds more potent than rifampicin (MIC:64 mu g/mL) and isoniazid (MIC:>128 mu g/mL) against MDR-MTB strain, but was less active than TAM16 (MIC:<0.06 mu g/mL against the tested two strains). The hybrid 6d also showed low cytotoxicity towards VERO cell (CC50:128 mu g/mL), but it was inferior to TAM16 in metabolic stability and in vivo pharmacokinetic profiles. Interested yet? Keep reading other articles of 497-23-4, you can contact me at any time and look forward to more communication. Application In Synthesis of Furan-2(5H)-one.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem