Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is , belongs to benzofurans compound. In a document, author is Lu, Shenci, Application In Synthesis of 5-Methylfuran-2(5H)-one.
Diastereo- and Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade
We present herein an unprecedented stereoselective synthesis of bridged biaryls with defined axial and central chirality from readily available starting materials. This N-heterocyclic carbene-catalyzed method proceeds through propargylic substitution of azolium enolates followed by two-directional cyclization, as supported by DFT calculation. A range of benzofuran/indole-derived bridged biaryls bearing an eight-membered lactone are accessed with uniformly high stereoselectivity (>98:2 dr, mostly >98% ee).
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 591-11-7, in my other articles. Application In Synthesis of 5-Methylfuran-2(5H)-one.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem