Dearomative Michael addition involving enals and 2-nitrobenzofurans realized under NHC-catalysis was written by Dyguda, Mateusz;Skrzynska, Anna;Sieron, Leslaw;Albrecht, Lukasz. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Computed Properties of C8H5NO3 This article mentions the following:
The first enantioselective dearomative Michael addition between α,β-unsaturated aldehydes and 2-nitrobenzofurans under N-heterocyclic carbene activation was described. The reaction proceeded via addition of homoenolate to Michael acceptors leading to the formation of biol. important heterocycles such as I [Ar = Ph, 3-anisyl, 2-furyl, etc.] with high yields and stereoselectivities. Their functionalization potential was confirmed in selected, diastereoselective transformations. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Computed Properties of C8H5NO3).
2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Computed Properties of C8H5NO3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem