Discovery of 6296-53-3

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6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, belongs to benzofurans compound, is a common compound. name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamideIn an article, once mentioned the new application about 6296-53-3.

Preparation of diversely substituted beta-functionalised styrenes by microwave-assisted olefin cross-metathesis (CM) is described. This method can be also employed in the synthesis of beta-deuterated alpha,beta-unsaturated sulfones from inexpensive allylbenzenes, though unprecedented one-pot isomerisation/deuteration/cross-metathesis sequence. One of such obtained CM products has been utilised in a new scalable synthesis of Apremilast (6), a potent and orally active phosphodiesterase 4 and tumour necrosis factor-alpha inhibitor. The same strategy was used in synthesis of an optical antipode of 6, ent-Apremilast.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3483O – PubChem