Wedelolactone suppresses IL-1beta maturation and neutrophil infiltration in Aspergillus fumigatus keratitis was written by Cheng, Min;Lin, Jing;Li, Cui;Zhao, Wenyi;Yang, Hua;Lv, Leyu;Che, Chengye. And the article was included in International Immunopharmacology in 2019.Product Details of 524-12-9 The following contents are mentioned in the article:
Wedelolactone, a chem. compound extracted from Wedelia calendulacea or Eclipta alba, has been reported to regulate key steps in inflammation. Hence, we aimed to characterize the impact of wedelolactone in Aspergillus fumigatus keratitis. Aspergillus fumigatus was used to establish an in vivo mouse model of fungal keratitis and an in vitro model of THP-1 macrophages. Mice and THP-1 macrophages were pre-treated with wedelolactone. Clin. evaluation, myeloperoxidase (MPO) assay, neutrophil staining, western blot and quant. polymerase chain reaction (qRT-PCR) were used to assess the effect of wedelolactone on A. fumigatus infection. Therapeutic effect of natamycin treatment with or without wedelolactone was measured via slit lamp microscopy. We confirmed that wedelolactone attenuated the infiltration of neutrophils and decreased MPO level at earlier time points in mice with A. fumigatus keratitis. Pre-treatment with wedelolactone decreased pro-inflammatory cytokine interleukin 1 beta (IL-1beta) maturation by inhibiting caspase-1 activity. Combined with natamycin, wedelolactone protected corneal transparency in mouse with fungal keratitis. Present findings indicated that wedelolactone reduced host immune responses by attenuating neutrophil recruitment and IL-1beta maturation in Aspergillus fumigatus keratitis. Wedelolactone combined with an antifungal medicine could be a potential therapy for reducing lesion severity in fungal keratitis. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Product Details of 524-12-9).
1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 524-12-9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem