Category: benzofurans

A new model applied for evaluating a rhenium-diselenium drug: breast cancer cells stimulated by cytokines induced from polynuclear cells by LPS was written by Veena, Vijay;Harikrishnan, Adhikesavan;Lakshmi, Basavegowda;Khanna, Sunali;Desmaele, Didier;Collery, Philippe. And the article was included in Anticancer Research in 2020.Recommanded Product: 76-54-0 This article mentions the following:

Background/aim: New anticancer drugs are usually tested on cancer cells in culture in a standard medium. We stimulated immune polynuclear cells by lipopolysaccharides to obtain an enriched medium (EM) containing inflammatory cytokines more closely reflecting the tumor microenvironment and tested a rhenium-diselenium (Re-diSe) drug in this new model. Concentrations of cytokines were compared with a control medium (CM).</div> Materials and methods: Human-derived breast cancer cells were grown in culture either in CM or EM with or without Re-diSe. Assays of tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), interleukin 1 beta (IL1β), transforming growth factor-beta (TGFβ), insulin growth factor 1 (IGF1) and vascular epidermal growth factor A (VEGFA) were performed by enzyme-linked immunosorbent assays. The production of reactive oxygen species (ROS) was determined by 2,7-dichlorofluorescein test. The cell growth was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tests. Results: Concentrations of TNFα, IL6 and Il1β were observed to be significantly higher in EM than in CM. There was no difference for TGFβ, IGF1 and VEGFA. The cells were sensitive to Re-diSe, with reduced concentrations of TGFβ, IGF1, VEGFA and ROS, but the half-maximal inhibitory concentration was significantly higher in EM than in CM. Conclusion: The efficacy of the Re-diSe drug was confirmed in this model of aggressive cancer. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Recommanded Product: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of a novel and synthetic HematoMiR technology that broadly modulates quiescence of stem cells and enhances HSC expansion was written by Uslu, Merve;Kocabas, Fatih. And the article was included in Cellular and Molecular Life Sciences in 2022.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Hematopoietic stem cell (HSCs) transplantation is the primary therapeutic modality used to treat hematopoietic disorders. It centers on the capability of a small quantity of HSCs to repopulate whole blood lineages. Along with limited availability of suitable donors, the need for sufficient number of donor HSCs is still challenging in clin. relevance. This has been addressed by ex vivo HSC expansion albeit with partial success, and thus development of an alternative strategy that could improve HSC expansion is required. To that end, we aimed to build HematoMiR, an oligo-based technol. that broadly targets HSC quiescence factors. Here, we show that HematoMiRs and their combinations targeting over 50 factors involved in HSC quiescence could induce robust ex vivo murine and human HSC expansion. In particular, HematoMiR-5 treatment enhanced cell cycle through down-regulation of neg. cell cycle regulators in HSCs. HematoMiR-5 treated HSPCs had reduced DNA damage during the course of ex vivo expansion. Moreover, HematoMiR-5 treatment led to sustained HSC self-renewal ability and a low apoptosis rate. In addition, HematoMiR-5 expanded HSCs demonstrated successful engraftment and repopulation capacity in the recipient animals. Furthermore, combinatorial treatments of HematoMiR-2 and 5 allowed vigorous ex vivo HSC expansion. These findings demonstrate that novel and synthetic HematoMiR technol. is feasible for HSC ex vivo expansion through the sequence-dependent modulation of numerous HSC quiescence modulators. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis was written by Larrouyet-Sarto, Maria Luciana;Tamura, Augusto Shuiti;Alves, Vinicius Santos;Santana, Patricia T.;Ciarlini-Magalhaes, Roberta;Rangel, Thuany Prado;Siebert, Cassiana;Hartwig, Josiane R.;Marcon dos Santos, Tiago;Wyse, Angela T. S.;Takiya, Christina Maeda;Coutinho-Silva, Robson;Savio, Luiz Eduardo Baggio. And the article was included in Purinergic Signalling in 2020.Recommanded Product: 76-54-0 This article mentions the following:

Sepsis is a severe disease characterized by an uncontrolled systemic inflammation and consequent organ dysfunction generated in response to an infection. Extracellular ATP acting through the P2X7 receptor induces the maturation and release of pro-inflammatory cytokines (i.e., IL-1β) and the production of reactive nitrogen and oxygen species that lead to oxidative tissue damage. Here, we investigated the role of the P2X7 receptor in inflammation, oxidative stress, and liver injury in sepsis. Sepsis was induced by cecal ligation and puncture (CLP) in wild-type (WT) and P2X7 knockout (P2X7-/-) mice. The oxidative stress in the liver of septic mice was assessed by 2′,7′-dichlorofluorescein oxidation reaction (DCF), thiobarbituric acid-reactive substances (TBARS), and nitrite levels dosage. The status of the endogenous defense system was evaluated through catalase (CAT) and superoxide dismutase (SOD) activities. The inflammation was assessed histol. and by determining the expression of inflammatory cytokines and chemokines by RT-qPCR. We observed an increase in the reactive species and lipid peroxidation in the liver of septic WT mice, but not in the liver from P2X7-/- animals. We found an imbalance SOD/CAT ratio, also only WT septic animals. The number of inflammatory cells and the gene expression of IL-1 β, IL-6, TNF-α, IL-10, CXCL1, and CXCL2 were higher in the liver of WT septic mice in comparison to P2X7-/- septic animals. In summary, our results suggest that the P2X7 receptor might be a therapeutic target to limit oxidative stress damage and liver injury during sepsis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Recommanded Product: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A novel spectrofluorimetric method for the determination of calcitonin in ampuls through derivatization with fluorescamine was written by Kocdan, Deniz;Basan, Hasan. And the article was included in Luminescence in 2013.Product Details of 38183-12-9 This article mentions the following:

In this study, a simple, sensitive, and selective spectrofluorimetric method was developed for the determination of salmon calcitonin (sCT) in ampuls. The method is based on the reaction between sCT and fluorescamine at pH 8.5 in borate buffer, resulting in a highly fluorescent derivative Fluorescence of derivatized sCT solutions was measured by setting the excitation and emission monochromators and slit widths to 390, 484, and 10 nm, resp. Several derivatization parameters were optimized. A calibration graph was constructed using standard solutions of the derivatized calcitonin in the range 0.5-6.0 μg/mL. Limit of detection and limit of quantification values were determined to be 0.124 and 0.372 μg/mL, resp. The proposed method was successfully applied for the determination of sCT in com. available ampuls. High recovery values (101.0-102.0%), and a low relative standard deviation (RSD %) value (5.3-5.4) proved the accuracy and precision of the proposed method. An isocratic reversed-phase high-performance liquid chromatog. (HPLC) method, as a reference, was also developed for the determination of sCT. A reversed-phase Nucleosil C₁₈ column (250 mm × 4.6 mm i.d., 10 μm particle size, 120 Å pore size) was used and the detector was set at 210 nm. Statistical comparison of the results of the 2 methods showed clearly that there was no significant difference between them. Copyright © 2012 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Product Details of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities was written by Zhang, Yajie;Garcia-Gabilondo, Miguel;Grayston, Alba;Feiner, Irene V. J.;Anton-Sales, Irene;Loiola, Rodrigo A.;Llop, Jordi;Ramos-Cabrer, Pedro;Barba, Ignasi;Garcia-Dorado, David;Gosselet, Fabien;Rosell, Anna;Roig, Anna. And the article was included in Nanoscale in 2020.Application of 38183-12-9 This article mentions the following:

Designing theranostic nanocarriers with high protein payload and multimodality tracking without cross interferences between the different imaging probes and the delicate protein cargo is challenging. Here, chem. modifications of poly(lactic-co-glycolic acid) (PLGA) to produce nanocapsules (NCs) that incorporate several imaging moieties are reported. The biocompatible and biodegradable PLGA-NCs can be endowed with a magnetic resonance imaging (MRI) reporter, two fluorescence imaging probes (blue/NIR) and a positron emission tomog. (PET) reporter. The modular integration of these imaging moieties into the shell of the NCs is successfully achieved without affecting the morphochem. properties of the nanocarrier or the protein loading capacity. In vivo biodistribution of the NCs is monitored by MRI, PET and NIRF and the results from different techniques are analyzed comparatively. The viabilities of two different human endothelial cells in vitro show no toxicity for NC concentration up to 100μg mL^-1. The morbidity of mice for 2 wk after systemic administration and the hepatic/pancreatic enzymes at the plasma level indicate their in vivo biosafety. In summary, the new theranostic PLGA nanoplatform presented here shows versatile in vitro/in vivo multimodal imaging capabilities, excellent biosafety and over 1 wt% protein loading. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A feasible fluorimetric approach anchored in diaryl pyrrolone derivative for the facile analysis of milnacipran in tablets; evaluation of the method greenness was written by Derayea, Sayed M.;Madian, Hoda;Samir, Ebtihal;Hamad, Ahmed A.;Badr El-Din, Khaled M.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2022.Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

In the present work a new, feasible, and green approach was employed for the anal. of milnacipran. A drug is used in the management of depression in addition to fibromyalgia. It inhibits of the reuptake of two essential neurotransmitters serotonin and nor-adrenaline. In slightly alk. buffer (pH 8.5) the primary amino group of milnacipran reacted with fluorescamine to give a substituted pyrrolone derivative which exhibited high fluorescence activity. The fluorescence of produced derivative was measured at (λ_ex 385 nm, λ_em 477 nm), and the exptl. factors were cautiously optimized. The measured intensity of fluorescence was plotted vs. the resp. concentration of milnacipran to setup the calibration plot which has a linear concentration range of 50-300 ng/mL. The ICH guidelines were utilized to totally validate the presented approach. In addition the method could be efficiently incorporated in the anal. of com. milnacipram tablets with no considerable effect on the results of the assay for milnacipran. The developed approach is characterized by its high simplicity and greenness of the procedure which make it suitable for routine anal. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice was written by Wang, Xuerui;Yin, Zequn;Meng, Xianshe;Yang, Daigang;Meng, Huawen;Liao, Chenzhong;Wei, Lingling;Chen, Yuanli;Yang, Xiaoxiao;Han, Jihong;Duan, Yajun;Zhang, Shuang. And the article was included in Journal of Functional Foods in 2022.Reference of 76-54-0 This article mentions the following:

Parkinson’s disease (PD) is the most common neurodegenerative disease. Daidzein (DAI) is one of the most commonly ingested phytoestrogens with anti-oxidant properties. However, the effects of DAI on oxidative stress in PD has not been reported. In this study, we used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for i.p. injection of C57/BL6J mice for continuous 7 days to simulate the pathol. process of PD. Results showed that DAI improved the movement disorders and reduced the loss of DA neurons in the brain of mice induced by MPTP. Mechanistically, in vitro, DAI pretreatment up-regulated the expression of Nrf2 and its downstream SOD1 and SOD2 by inhibiting the activity of GSK3β in lipopolysaccharide-stimulated BV2 cells; in vivo, DAI pretreatment attenuated GSK3β activity, increased the expression of Nrf2 and downstream anti-oxidants SOD1, SOD2 and CAT. Our data demonstrated that DAI restrains oxidative stress in PD by regulating the GSK3β/Nrf2 pathway. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and antimicrobial activities of some new benzofuro[3,2-d]pyrimidines was written by Basawaraj, Raga;Khandre, Omakar;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2011.Application of 54802-10-7 This article mentions the following:

2-(4-Nitrophenyl)-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidine was prepared by cyclocondensation of 3-amino-2-benzofurancarboxamide with 4-nitrobenzaldehyde in presence of catalytic quantity of concentrate hydrochloric acid. The nucleophilic displacement reaction of the above compound with phosphorus oxychloride furnished 4-chloro-2-(4-nitrophenyl)benzofuro[3,2-d]pyrimidine. Benzofuro[3,2-d]pyrimidine derivatives, e.g., I, were prepared by condensation of 4-chloro-2-(4-nitrophenyl)benzofuro[3,2-d]pyrimidine with amines. Synthesized compounds were characterized on the basis of spectral and anal. data. All the compounds were screened for biol. activity. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Involvement of sex hormones, oxidative stress, ACE and ACE2 activity in the impairment of renal function and remodelling in SHR was written by Melo, Antonio F. Junior;Dalpiaz, Polyana Lima M.;Escouto, Leonardo da Silva;Sousa, Glauciene Januario;Aires, Rafaela;Oliveira, Nayara Damacena;Carmona, Adriana Karaoglanovic;Gava, Agata Lages;Bissoli, Nazare Souza. And the article was included in Life Sciences in 2020.HPLC of Formula: 76-54-0 This article mentions the following:

Hypertension is a relevant sex and sex hormones-dependent risk factor where the cardiovascular and renal health of the population are concerned. Men experience greater losses of renal function (RF) than women, but the mechanisms remain somewhat unclear. Our goal was to evaluate the relationship between oxidative stress (OS), angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) activities and RF in male and female SHR. Twelve-week-old spontaneously hypertensive rats (SHR) were submitted to either castration or SHAM surgery and divided into 4 groups, SHAM or Castrated (CAST) males or females. After 51 days we evaluated RF (inulin and sodium para-aminohippurate), ACE and ACE2 activities (fluorimetry), OS (flow cytometry), collagen deposition (picrosirius red) and protein expression (western blot). Males presented lower RF than females and castration impaired this parameter in both groups. Sexual dimorphism was not observed regarding OS and inflammation; however, castration increased this parameter more severely in males than in females. SHAM males exhibited higher collagen deposition than females, though castration increased it in both sexes, eliminating the difference. We found sexual dimorphism regarding renal ACE and ACE2 activities, which were lower in males than in females. Although castration did not alter ACE activity, it reduced ACE2 activity in females and increased it in males. These results indicate that sex hormones affect RF in SHR. As alterations in the oxidative system were capable of promoting podocyte injury, inflammation, and collagen deposition, we put forward that these effects are differently modulated by ACE and ACE2. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sequential detection of Fe^3+/2+ and pyrophosphate by a colorimetric chemosensor in a near-perfect aqueous solution was written by Chae, Ju Byeong;Jang, Hyo Jung;Kim, Cheal. And the article was included in Photochemical & Photobiological Sciences in 2017.Application of 54802-10-7 This article mentions the following:

A novel colorimetric chemosensor 1 was designed and synthesized for Fe^3+/2+ and pyrophosphate. Sensor 1 showed a selective color change toward both Fe³⁺ and Fe²⁺ from yellow to brown in a near-perfect aqueous solution The detection limits (0.36 μM and 0.37 μM) for Fe³⁺ and Fe²⁺ were much lower than the guideline (5.37 μM) set by the Environmental Protection Agency (EPA) for iron in drinking water. Sensor 1 could be used to quantify Fe³⁺ in real water samples. Moreover, the resulting Fe³⁺-2·1 complex can detect pyrophosphate selectively over various anions especially including phosphate-based anions through a metal-complex displacement method. Based on UV-vis titrations, Job plot and ESI-mass spectrometry analyses, the sensing mechanisms of Fe³⁺, Fe²⁺ and PPi were proposed. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem