Category: benzofurans

Functionalization of nano-emulsions with an amino-silica shell at the oil-water interface was written by Attia, Mohamed F.;Anton, Nicolas;Bouchaala, Redouane;Didier, Pascal;Arntz, Youri;Messaddeq, Nadia;Klymchenko, Andrey S.;Mely, Yves;Vandamme, Thierry F.. And the article was included in RSC Advances in 2015.Recommanded Product: 38183-12-9 This article mentions the following:

Nano-emulsions are very promising nano-carriers with high potential for loading lipophilic drugs. However, the surface of oil nano-droplets is a dynamic oil/water interface stabilized by surfactants, and its chem. modification to graft ligands is highly challenging. In this study we developed a new protocol for modification of the nano-droplets surface through a silica shell terminated by amine functions. It enabled preparation of nanocapsules of 65, 85 and 120 nm diameters with a surface coverage of ca. 2 amino groups per nm². The nanocapsule surface was then functionalized (41% efficiency) by a model fluorescent ligand (coumarin blue) with a carboxylic function. The evidence for the successful grafting was provided by spectrofluorometry, Förster resonance energy transfer, at. force microscopy coupled with fluorescence imaging and fluorescence correlation spectroscopy. This simple protocol for surface functionalization of the liquid/liquid interface of lipid droplets may constitute a real advance regarding potential applications that need efficient decoration of droplets with ligands. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease was written by Stankova, Pavla;Kucera, Otto;Peterova, Eva;Lotkova, Halka;Maseko, Tumisang Edward;Nozickova, Katerina;Cervinkova, Zuzana. And the article was included in International Journal of Molecular Sciences in 2020.Computed Properties of C20H10Cl2O5 This article mentions the following:

Maladaptation of mitochondrial oxidative flux seems to be a considerable feature of nonalcoholic fatty liver disease (NAFLD). The aim of this work was to induce NAFLD in mice fed a Western-style diet (WD) and to evaluate liver mitochondrial functions. Experiments were performed on male C57BL/6J mice fed with a control diet or a WD for 24 wk. Histol. changes in liver and adipose tissue as well as hepatic expression of fibrotic and inflammatory genes and proteins were evaluated. The mitochondrial respiration was assessed by high-resolution respirometry. Oxidative stress was evaluated by measuring lipoperoxidation, glutathione, and reactive oxygen species level. Feeding mice a WD induced adipose tissue inflammation and massive liver steatosis accompanied by mild inflammation and fibrosis. We found decreased succinate-activated mitochondrial respiration and decreased succinate dehydrogenase (SDH) activity in the mice fed a WD. The oxidative flux with other substrates was not affected. We observed increased ketogenic capacity, but no impact on the capacity for fatty acid oxidation We did not confirm the presence of oxidative stress. Mitochondria in this stage of the disease are adapted to increased substrate flux. However, inhibition of SDH can lead to the accumulation of succinate, an important signaling mol. associated with inflammation, fibrosis, and carcinogenesis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ring Opening Metathesis Polymerization of Bicyclic α,β-Unsaturated Anhydrides for Ready-to-be-grafted Polymers Having Tailored pH-Responsive Degradability was written by Kim, Heejin;Kim, Sungwhan;Kang, Sunyoung;Song, Youngjun;Shin, Suyong;Lee, Seonju;Kang, Minji;Nam, So Hee;Lee, Yan. And the article was included in Angewandte Chemie, International Edition in 2018.HPLC of Formula: 38183-12-9 This article mentions the following:

Polymers having α,β-unsaturated anhydrides as repeating units were synthesized by ring opening metathesis polymerization (ROMP). The anhydride moieties were ready-to-be-grafted with amines to form acid-labile cis-α,β-unsaturated acid amide linkages. The pH-responsive reversible de-grafting can be controlled by changing the intramol. accessibility between acid and amide groups. The alendronate-grafted ROMP polymers showed distinct pH-dependent cytotoxicity according to the anhydride structures. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Optical Properties of Poly(2-(5-bromo benzofuran-2-yl)-2-oxoethyl methacrylate)/Organoclay Nanocomposites was written by Kurt, Adnan;Koca, Murat. And the article was included in Arabian Journal for Science and Engineering in 2015.Related Products of 38220-75-6 This article mentions the following:

Novel nanocomposites of benzofuran-containing polymer poly(2-(5-bromo benzofuran-2-yl)-2-oxoethyl methacrylate) with different contents of organoclay were prepared and characterized with FTIR, XRD and SEM techniques. The thermal decomposition temperature of poly(BOEMA)/organoclay nanocomposites is higher than that of pure poly(BOEMA) about 5-14 °C at 10% weight loss. The optical characterization was tested with a UV-VIS spectrophotometer. Transmittances of nanocomposites decreased to lower values by organoclay loading. Dispersion parameters such as steepness parameter, single-oscillator parameter, average oscillator position and strength and moments of the imaginary part of the optical spectrum were changed as a function of organoclay nanofiller. As the organoclay content increased to 5% in the polymer matrix, the existence of wide-band tails increased to 1.30 eV, whereas the optical energy gap decreased to 2.92 eV. Anal. reveals that the type of transition is the indirectly allowed one. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Related Products of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Green and sensitive spectrofluorimetric method for the determination of two cephalosporins in dosage forms was written by Abdel-Aziz, Heba;Tolba, M. M.;El-Enany, N.;Aly, F. A.;Fathy, M. E.. And the article was included in Royal Society Open Science in 2021.Category: benzofurans This article mentions the following:

Using two green and sensitive spectrofluorimetric methods, we quantified two cephalosporins, cefepime (CFM) and cefazolin (CFZ), in raw and pharmaceutical formulations. The first method is based on the reaction between CFM and fluorescamine (borate buffer, pH 8), which yields a highly fluorescent product. After excitation at 384 nm, the fluorescent product emits light at 484 nm. At concentration ranges from 12.0 to 120.0 ng ml^-1, the relative fluorescence intensity/concentration curve was linear with a limit of quantification (LOQ) of 2.46 ng ml^-1. The second method relied on measuring the CFZ quenching action on acriflavine fluorescence through formation of an ion-associate complex using Britton-Robinson buffer at pH 8. We measured acriflavine fluorescence at 505 nm after excitation at 265 nm. The decrease in acriflavine fluorescence intensity was CFZ concentration-dependent. Using this method, we quantified CFZ in concentrations ranging from 1 to 10 μg ml^-1 with a LOQ of 0.48 μg ml^-1. We studied and optimized the factors influencing reaction product formation. Moreover, we adapted our methods to the investigation of the mentioned drugs in raw and pharmaceutical formulations with greatly satisfying results. We statistically validated our methods according to International Council on Harmonisation Guidelines. The obtained results were consistent with those obtained with the official high-performance liquid chromatog. methods. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Category: benzofurans).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Utility of experimental design in pre-column derivatization for the analysis of tobramycin by HPLC-fluorescence detection: application to ophthalmic solution and human plasma was written by El-Zaher, Asmaa A.;Mahrouse, Marianne A.. And the article was included in Analytical Chemistry Insights in 2013.Formula: C17H10O4 This article mentions the following:

A novel, selective, and sensitive reversed phase high-performance liquid chromatog. (HPLC) method coupled with fluorescence detection was developed for the determination of tobramycin (TOB) in pure form, in ophthalmic solution, and in spiked human blood plasma. Since TOB lacks UV absorbing chromophores and native fluorescence, pre-column derivatization of TOB was carried out using fluorescamine reagent (0.01%, 1.5 mL) and borate buffer (pH 8.5, 2 mL). Exptl. design was applied for optimization of the derivatization step. The resulting highly fluorescent stable derivative was chromatographed on C₁₈ column and eluted using MeOH:water (60:40, volume/volume) at a flow rate of 1 mL min^-1. A fluorescence detector (λ_ex 390, and λ_em 480 nm) was used. The method was linear over the concentration range 20-200 ng mL^-1. The structure of the fluorescent product was proposed, the method was then validated and applied for the determination of TOB in human plasma. The results were statistically compared with the reference method, revealing no significant difference. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Trace determination of lenalidomide in plasma by non-extractive HPLC procedures with fluorescence detection after pre-column derivatization with fluorescamine was written by Khalil, Nasr Y.;Darwish, Ibrahim A.;Wani, Tanveer A.;Al-Majed, Abdel-Rahman A.. And the article was included in Chemistry Central Journal in 2013.Reference of 38183-12-9 This article mentions the following:

Background: Lenalidomide (LND) is a new potent drug used for treatment of multiple myeloma. For its pharmacokinetic studies and therapeutic monitoring, a proper anal. method was required. Results: In this study, a non extractive and simple pre-column derivatization procedures have been proposed, for the for trace determination of lenalidomide (LND) in human plasma by HPLC with fluorescence detection. Plasma samples were treated with acetonitrile for protein precipitation then treated with copper acetate to form stable complexes with the biogenic amines and mask their interference with the derivatization reaction of LND. Treated plasma samples containing LND was derivatized with fluorescamine (FLC) in aqueous media at ambient temperature Separation of the derivatized LND was performed on Hypersil BDS C18 column (250 × 4.6 mm, 5 μm particle size) using a mobile phase consisting of phosphate buffer (pH 4):methanol:tetrahydrofuran (70:10:20, volume/volume) at a flow rate of 1.0 mL/min. The derivatized samples were monitored at an emission wavelength of 495 nm after excitation at a wavelength of 382 nm. Under the optimum chromatog. conditions, a linear relationship with good correlation coefficient (r = 0.9997, n = 9) was found between the peak area and LND concentrations in the range of 2-100 ng/mL. The limits of detection and quantitation were 0.8 and 2.30 ng/mL, resp. The intra- and inter-assay precisions were satisfactory and the accuracy of the method was proved. The recovery of LND from the spiked human plasma was 99.30 ± 2.88. Conclusions: The proposed method had high throughput as the anal. involved simple sample pre-treatment procedure and a relatively short run-time (<15 min). The results demonstrated that the method would have a great value when it is applied in the therapeutic monitoring and pharmacokinetic studies for LND. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers was written by Insua, Ignacio;Liamas, Evangelos;Zhang, Zhenyu;Peacock, Anna F. A.;Krachler, Anne Marie;Fernandez-Trillo, Francisco. And the article was included in Polymer Chemistry in 2016.Application of 38183-12-9 This article mentions the following:

Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa’s elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimize particle size and charge, and their stability under physiol. conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Harmless-Harmful Switchable and Uninterrupted Laccase-Instructed Killer for Activatable Chemodynamic Therapy was written by Zhou, Tian-Jiao;Xu, Yuan;Xing, Lei;Wang, Yi;Jiang, Hu-Lin. And the article was included in Advanced Materials (Weinheim, Germany) in 2021.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular hydrogen peroxide (H₂O₂) into hydroxyl radicals (OH·). Although many studies on H₂O₂ supplementation have been conducted to improve the therapeutic effect of CDT, few studies have focused on the application of superoxide radical (O₂^-·) in CDT, which may result in better efficacy. A major concern about O₂^-·-mediated CDT is its tendency to induce serious oxidative damage to normal tissues, which may be addressed by using a degradable O₂^-· scavenger. Here, a harmless-harmful switchable and uninterrupted laccase (LAC)-instructed killer (HULK) is constructed, which is the first CDT agent accelerated by LAC-instructed O₂^-· generation and possesses a harmless-harmful switchable effect because of the photodegradation of the O₂^-· scavenger iron-chlorin e6 (FeCe6). LAC-instructed substrate oxidation effectively catalyzes O₂-· production with the help of intracellular reduction, thereby promoting the conversion of Fe³⁺ to Fe²⁺, accelerating the generation of OH·, and inducing tumor cell apoptosis and necrosis. The introduced O₂-· scavenger FeCe6 is quickly photodegraded during irradiation, while LAC-instructed O₂^-· generation proceeds as before, resulting in activatable CDT. This work not only provides the first strategy for LAC-instructed O₂^-· generation but also presents new insight into activatable CDT. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gas chromatographic analysis of benzofuran derivatives was written by Nakanishi, Teruo;Ito, Kiyoshi. And the article was included in Nippon Nogei Kagaku Kaishi in 1969.COA of Formula: C10H8O3 This article mentions the following:

Retention times (tr in min) of 53 benzofuran derivatives are given for 3 stationary phases at 140-300°. The columns were: (1) 5% diethylene glycol adipate on Chromosorb W, 3 mm inner diameter × 1.11 m; (2) 20% Apiezon grease L on Neosorb NC, 3 mm inner diameter × 1.11 m; (3) 10% Silicone SE-30 on Chromosorb W, 3 mm inner diameter × 0.74 m. A H flame ionization detector was used in each case. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem