Category: benzofurans

6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, Safety of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, belongs to benzofurans compound, is a common compound. In a patnet, author is Baashen, Mohammed A., once mentioned the new application about 6296-53-3.

A Simple and Efficient Process for the Synthesis of Novel Heterocycles Containing Benzofuran Moiety Using Thiocarbohydrazide as a Precursor

A simple and efficient process for the synthesis of novel heterocycles starting from thiocarbohydrazide was reported. Reaction of 2-acetylbenzofuran (1) and thiocarbohydrazide (2) in ethanol containing acetic acid produced the corresponding thiocarbohydrazone 3 in 86% yield. Reaction of 3 and isatin (4) gave N,2-bis(2-oxoindolin-3-ylidene)hydrazine-1-carbothiohydrazine (6) in 65% yield, rather than the expected product, 3-[(1-methyl-1-benzofur-2-ylmethylidene)amino]-1-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}thiourea (5). Reaction of 2-((3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazine carbothioamide (9) and chloroacetic acid or hydrazonoyl chloride 11 in basic medium gave (Z)-2-((E)-((3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazono)thiazolidin-4-one (10) or 2-((E)-2-((3-(benzofuran-2-yl)-1- phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)-4-((E)-(4-fluorophenyl)diazenyl)-5-methylthiazole (12) in 62% or 74%, respectively.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, Formula: C7H10N2O4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4, belongs to benzofurans compound. In a document, author is Long, Yi.

Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium barbarum

Eleven new meroterpenoids, bipolahydroquinones A-C (1-3), cochlioquinones I-N (4-8 and 11), and isocochlioquinones F and G (9 and 10), together with six known ones, were obtained from an endophytic fungus Bipolaris sp. L1-2 from Lycium barbarum. Compound 2 is the first example of cochlioquinone derivatives possessing a benzofuran moiety. The structures and absolute configurations of the new compounds were elucidated by spectroscopic data interpretation, single-crystal X-ray diffraction analysis, chemical transformations, and biosynthetic considerations. Compounds 3, 4, and 6-8 showed cytotoxicity against NCI-H226 and/or MDA-MB-231 with IC50 values ranging from 5.5 to 9.5 mu M.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 97148-39-5, in my other articles. Formula: C7H10N2O4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is C5H6O2, belongs to benzofurans compound, is a common compound. In a patnet, author is Banzato, Thais P., once mentioned the new application about 591-11-7, Category: benzofurans.

Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis

Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (1-4), with a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane skeleton; propolonones A-C (5-7), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]-chromane skeleton; and propolol A (8), with a 6-(3-benzyl-benzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 591-11-7. The above is the message from the blog manager. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 66357-35-5, Name is Ranitidine. In a document, author is Gong, Julin, introducing its new discovery. Application In Synthesis of Ranitidine.

Tandem addition/cyclization for synthesis of 2-aroyl benzofurans and 2-aroyl indoles by carbopalladation of nitriles

The first example of the palladium-catalyzed tandem addition/cyclization of 2-(2-acylphenoxy)acetonitriles with arylboronic acids has been developed, providing a new strategy for the synthesis of 2-aroyl benzofurans with excellent chemoselectivity and wide functional group compatibility. Preliminary mechanistic experiments indicate that this tandem process involves sequential nucleophilic addition generating 2-(2-acylphenoxy)-1-phenylethan-1-one followed by an intramolecular cyclization. This methodology has also been applied to the synthesis of 2-aroyl indoles and the potent CYP19 inhibitor 1-(benzofuran-2-yl(phenyl)methyl)-1H-1,2,4-triazole.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4. In an article, author is Solomatina, Anastasia, I,once mentioned of 97148-39-5, Computed Properties of C7H10N2O4.

Blood-Brain Barrier Penetrating Luminescent Conjugates Based on Cyclometalated Platinum(II) Complexes

Herein we report on the synthesis, structural characterization and photophysical properties of cyclometalated Pt(II) complexes [Pt(N<^>C)(PPh2(C6H4COOH))Cl] (where N<^>C ligands are 2-phenylpyridine, (2-benzofuran-3-yl)pyridine, and (2benzo[b]tiophen-3-yl) pyridine) and their conjugates with the histidine-containing RRRRRRRRRRHVLPKVQA peptide. This peptide contains the RHVLPKVQA sequence, which is responsible for antiamyloid activity, and the Arg9 RRRRRRRRR domain, which shows improved translocation through cell membranes. The chemistry underpinning the conjugation is regioselective complexation between Pt(II) complexes and histidine residue in the peptide. The prepared conjugates have been characterized using high-resolution mass spectrometry and NMR spectroscopy. It was shown that the conjugates are easily soluble in aqueous media and display emission band profiles essentially similar to those of the starting complexes but considerably higher luminescence quantum yield and much longer phosphorescence lifetime. MTT assay on HeLa cell culture revealed no cytotoxicity up to 10 mu M after 24 h of incubation. Ex vivo and in vivo neuroimaging experiments on both wild and amyloid peptide expressing strains of Drosophila melanogaster revealed that the conjugates penetrate the blood-brain barrier and are evenly distributed throughout the brain independently of the strain used.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 66357-35-5, Name is Ranitidine, molecular formula is , belongs to benzofurans compound. In a document, author is Olomola, Temitope O., COA of Formula: C13H22N4O3S.

Crystal structure of 1-(6-hydroxy-2-phenylbenzofuran-5-yl)ethan-1-one, C16H12O3

C16H12O3, orthorhombic, Pbca (no. 61), a = 10.7095(3) angstrom, b = 8.1455(2) angstrom, c = 27.5374(8) angstrom, V = 2402.20(11) angstrom(3), Z = 8, R-gt(F) = 0.0369, wR(ref)(F-2) = 0.0947, T = 173(2) K.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Zhu, Tianhan, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Product Details of 14400-67-0.

Preparation of NiCu Alloy Catalyst for the Hydrodeoxygenation of Benzofuran

A series of bimetallic NixCu(10-x)/SiO2(wherexis the mass fraction of Ni and the total metal loading was fixed at 10 wt%.) catalysts with different Ni/Cu mass ratio are prepared and characterized by X-Ray diffraction (XRD), N(2)adsorption-desorption, inductively coupled plasma mass spectrometry (ICP-MS), H(2)temperature-programmed reduction (H-2-TPR) and transmission electron microscope (TEM). The benzofuran (BF) hydrodeoxygenation (HDO) performance of as-prepared catalysts are evaluated in a fixed flow reactor. The results showed that the incorporation of Cu to Ni/SiO(2)catalyst can increase surface area of catalyst and improve the reducibility of nickel oxide species, which contributed to higher catalytic activity and total deoxygenated compounds yield. Moreover, the strong synergistic effect between Ni and Cu led to the formation of NiCu alloy at the Ni mass fraction of 5 wt% and thus induced smaller crystallite size and exposure of more active particles, which inevitably contributed to the improved HDO performance for Ni5Cu5/SiO(2)catalyst. At 300 degrees C, 3.0 MPa, MHSV=3.0 h(-1)and H-2/oil = 500(v/v), the total yield of deoxygenated products over Ni5Cu5/SiO(2)catalyst reached 86.0%, which is increased by 10.8% and 77.4% as compared to those of monometallic Ni/SiO2(75.2%) and Cu/SiO(2)catalysts (8.8%), respectively. Finally, a possible reaction network for HDO of BF on Ni5Cu5/SiO(2)catalyst was proposed. [GRAPHICS] .

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Synthetic Route of 591-11-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a article, author is Kitamura, Yuki, introduce new discover of the category.

Palladium-Catalyzed C-H Arylation of Benzofurans with Triarylantimony Difluorides for the Synthesis of 2-Arylbenzofurans

Pd-catalyzed regioselective C-H arylation is a useful tool for the chemical modification of aromatic heterocycles and 2-arylbenzofuran derivatives are of interest as biologically active substances. Herein, the reaction of triarylantimony difluorides with benzofurans under aerobic conditions in 1,2-DCE, using 5 mol% Pd (OAc)(2) and 2 eq. of CuCl2 at 80 degrees C, produced a variety of 2-arylbenzofurans in moderate-to-high yields. The reaction is sensitive to the electronic nature of the substituents on the benzene ring of the triarylantimony difluorides: an electron-donating group showed higher reactivity than an electron-withdrawing group. Single crystal X-ray analysis of tri(p-methylphenyl) antimony difluoride revealed that the central antimony atom exhibits trigonal bipyramidal geometry.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Sha, Qiang, once mentioned the application of 97148-39-5, Application In Synthesis of Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4, molecular weight is 186.1653, MDL number is MFCD03791040, category is benzofurans. Now introduce a scientific discovery about this category.

De novo synthesis of benzofurans via trifluoroacetic acid catalyzed cyclization/oxidative aromatization cascade reaction of 2-hydroxy-1,4-diones

A facile, one-pot method for the de novo synthesis of benzofurans from 2-hydroxy-1,4-diones is described. Using trifluoroacetic acid (TFA) as the catalyst and N-bromobutanimide (NBS) as the oxidant, 2-hydroxy-1,4-diones underwent a cyclization/oxidative aromatization cascade reaction to afford a variety of benzofuran derivatives in moderate to good yields. This is a practically useful method for the synthesis of benzofuran derivatives starting from 2-hydroxy-1,4-diones which is also a supplement of the Paal-Knorr furan synthesis. A preliminary mechanism study was undertaken to support the proposed mechanism during which a novel 1,6-conjugate addition reaction was revealed.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2, belongs to benzofurans compound, is a common compound. In a patnet, author is Hosseinihashemi, Seyyed Khalil, once mentioned the new application about 4412-91-3, Safety of 3-Furanmethanol.

Synthesis and Activity Evaluation of New Benzofuran-1,3,4-Oxadiazole Hybrids Against Wood-Degrading Fungi

A series of novel benzofuran-1,3,4-oxadiazole hybrids were synthesized and evaluated as antifungal agents. The synthetic pathway was started from salicylaldehyde, which afforded 5-(substituted benzylthio)-1,3,4-oxadiazole derivatives in moderate to good yields. The compounds were investigated for their antifungal potential against white-rot, Trametes versicolor and brown-rot, Poria placenta and Coniophora puteana fungi at different concentrations (500, 1000 ppm). The obtaining results demonstrated that most of the compounds at 500 ppm concentration did not exhibit acceptable antifungal effects but they had better antifungal activity at 1000 ppm concentration. Compounds 5a, 5c, and 5i showed inhibition percentages of 14.6%, 23.0%, and 14.7%, against the growth of P. placenta and C. puteana, respectively. Among the compounds, the 2-(benzofuran-2-yl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole (5h) hybrid was the most active one.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4412-91-3. The above is the message from the blog manager. Safety of 3-Furanmethanol.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem