Category: benzofurans

Chemistry is an experimental science, Safety of 2,5-Dimethylfuran-3(2H)-one, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound. In a document, author is Jaradat, Nidal.

Phytochemistry, traditional uses and biological effects of the desert plant Styrax officinalis L

Styrax officinalis L. is an important medicinal plant that grows in the desert, subtropics, temperate climate, and Mediterranean Basin regions.. It has been used for medicinal, religious, agricultural and cosmetic purposes. This review aimed to collect from the literature, all the available data about the phytochemistry, traditional medicinal uses, evidence-based uses, morphology and habitat of S. officinalis plant. This report is a review of the literature concerning S. officinalis chemical constituents, description, origin, traditional medicinal and evidence-based uses published from 1966 to date. Among the databases searched for primary literature references are Pubmed, Scientific Information Database, Scopus, Web of Science, Science Direct, Google and Google scholar. In this search, combinations of the keyword Styrax officinalis with the terms; antibacterial, antifungal, antioxidant, anticancer, phytochemistry, ethnopharmacology, traditional uses, folk uses, morphology, biological activity, therapeutic effects and toxicity were applied. The current review showed that various compounds have been isolated from S. officinalis: leaves, fruits, seeds, flowers and stems such as egonol, egonol oleate, americanin, several types of phenolic acids and benzofuran derivatives. These natural compounds and their synthetic derivatives in addition to the various parts used as extracts showed valuable biological activities including antitumor, hemolytic, anti-complement, anti-leukemic, antifungal, antibacterial, antioxidant and tyrosinase inhibitory activities. This review represented a summary of the information concerning S. officinalis different used parts. However, the areas of isolation and identification of the biologically active compounds of S. officinalis from the roots and rhizomes also investigation more biological activities of other plant parts are essential to cover all the scientific fields of S. officinalis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14400-67-0. Safety of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of Ranitidine, 66357-35-5, Name is Ranitidine, molecular formula is C13H22N4O3S, belongs to benzofurans compound. In a document, author is Li, Hong Xu, introduce the new discover.

Coumarin and Moracin Derivatives from Mulberry Leaves (Morus albaL.) with Soluble Epoxide Hydrolase Inhibitory Activity

This study identified three coumarins (1-3), and six moracin derivatives (4-9). The structures of these natural compounds were determined by the spectroscopic methods, including 1D and 2D NMR methods, and comparison with previous reported data. All of the isolated compounds were assessed for the effects on the soluble epoxide hydrolase (sEH) inhibitory activity. Among them, compounds1-7exhibited significant inhibitory effect with 100% inhibitory, with IC(50)values of 6.9, 0.2, 15.9, 1.1, 1.2, 9.9, and 7.7 mu M, respectively. A kinetic study revealed that compounds1-4, and6were competitive types of inhibitors, compounds5and7were mixed types of inhibitors. These results suggest that moracin and coumarin derivatives from mulberry leaves are significant sEH inhibitors.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 66357-35-5. Safety of Ranitidine.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2, belongs to benzofurans compound. In a document, author is Aleksic, Ivana, introduce the new discover, SDS of cas: 497-23-4.

N-Benzyl Derivatives of Long-Chained 4-Amino-7-chloro-quionolines as Inhibitors of Pyocyanin Production in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a leading cause of nosocomial infections that are becoming increasingly difficult to treat due to the occurrence of antibiotic resistant strains. Since P. aeruginosa virulence is controlled through quorum sensing, small molecule treatments inhibiting quorum sensing signaling pathways provide a promising therapeutic option. Consequently, we synthesized a series of N-octaneamino-4-aminoquinoline derivatives to optimize this chemotype’s antivirulence activity against P. aeruginosa via inhibition of pyocyanin production. The most potent derivative, which possesses a benzofuran substituent, provided effective inhibition of pyocyanin production (IC50 = 12 mu M), biofilm formation (BFIC50 = 50 mu M), and motility. Experimentally, the compound’s activity is achieved through competitive inhibition of PqsR, and structure-activity data were rationalized using molecular docking studies.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 497-23-4. SDS of cas: 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4. In an article, author is Yadav, Seema,once mentioned of 97148-39-5, SDS of cas: 97148-39-5.

Well-Defined N-Heterocyclic Carbene-Palladium Complexes as Efficient Catalysts for Domino Sonogashira Coupling/Cyclization Reaction and C-H bond Arylation of Benzothiazole

Well-defined and air-stable PEPPSI (Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation) themed palladium bis-N-heterocyclic carbene complexes have been developed for the domino Sonogashira coupling/cyclization reaction of 2-iodophenol with a variety of terminal alkynes and C-H bond arylation of benzothiazole with aryl iodides. The PEPPSI themed palladium complexes, 2a and 2b were synthesized in good yields from the reaction of corresponding imidazolium salts with PdCl2 and K2CO3 in pyridine. The new air-stable palladium-NHC complexes were characterized by NMR spectroscopy, X-ray crystallography, elemental analysis, and mass spectroscopy studies. The PEPPSI themed palladium(II) bis-N-heterocyclic carbene complexes 2a and 2b exhibited excellent catalytic activities for domino Sonogashira coupling/cyclization reaction of 2-iodophenol with terminal alkynes yielding benzofuran derivatives. In addition, the palladium complexes, 2a and 2b successfully catalyzed the direct C-H bond arylation of benzothiazole with aryl iodides as coupling partners in presence of CuI as co-catalyst.

Interested yet? Keep reading other articles of 97148-39-5, you can contact me at any time and look forward to more communication. SDS of cas: 97148-39-5.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Wang, Xiaomin, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Category: benzofurans.

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells

BackgroundPsoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects.ResultsPsoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1 alpha, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn’t inhibit the psoralen-induced ER stress in SMMC7721 cells.ConclusionsPsoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14400-67-0, Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, in an article , author is Ida, Hiroto, once mentioned of 6296-53-3, Recommanded Product: 6296-53-3.

Online fast pyrolysis of cellulose over titanium dioxide using tandem micro -reactor -GC -MS

In this work, the catalytic effect of titanium dioxide (TiO 2 ) on the online fast pyrolysis of cellulose was inves- tigated using a tandem micro reactor coupled to a gas chromatograph-mass spectrometer (GC -MS) system. This system was used in the following two different modes: in -situ and ex -situ . The results obtained with TiO 2 were compared with those of zeolite (HZSM-5) under identical pyrolysis conditions. Levoglucosan was the major product in the non -catalytic pyrolysis of cellulose. As for the catalytic pyrolysis of cellulose at 500 ? C with TiO 2 ( in -situ ), the peak of levoglucosan disappeared whereas aromatic hydrocarbons such as benzene, toluene and naphthalene were newly detected. In this case, oxygenated compounds such as furfural, furan, methylfuran were still observed for TiO 2 whereas oxygenated compounds (i.e, furan, benzofuran, methylbenzofuran, acetone and 2-butanone) with low yields were observed for in -situ catalytic pyrolysis with HZSM-5. For ex -situ catalytic py- rolysis of cellulose at 500 ? C using TiO 2 , oxygen -containing compounds were hardly formed, while various ar- omatic hydrocarbons were detected. When the ex -situ pyrolysis of cellulose with HZSM-5 was carried out, the yields of the aromatic hydrocarbons were comparable to those with TiO 2 .

Interested yet? Read on for other articles about 6296-53-3, you can contact me at any time and look forward to more communication. Recommanded Product: 6296-53-3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Synthetic Route of 497-23-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Cabrera-Pardo, Jaime R., introduce new discover of the category.

Exploring the Multi-Target Neuroprotective Chemical Space of Benzofuran Scaffolds: A New Strategy in Drug Development for Alzheimer’s Disease

Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder that slowly destroys memory. The precise mechanism of AD is still not entirely understood and remains under discussion; it is believed to be a multifactorial disease in which a number of mechanisms are involved in its pathogenesis. Worldwide, near 37 million people suffer from the effects of AD. As a cause of death for elderly, it is predicted that AD will rank third in the coming years, just behind cancer and heart disease. Unfortunately, AD remains an incurable condition. Despite the devastating problems associated with AD, there are only four FDA approved drugs for palliative treatment of this pathology. Hence, renewed scientific efforts are required not only to uncover more insights into the AD process but also to develop more efficient pharmacological tools against this disease. Due to the complexity and multiple mechanisms at play in the progression of AD, the development of drugs by rational design is extremely difficult. The existing drugs to fight against Alzheimer’s have had limited success, mainly due to their ability to modulate only one of the mechanisms involved in AD. As opposed to single-targeted strategies, the identification of small molecules able to affect multiple pathways involved in Alzheimer’s is a promising strategy to develop more efficient medicines against this disease. Central to existing efforts to develop pharmaceuticals controlling AD is the discovery of new chemicals displaying strong neuroactivity. Benzofurans are privileged oxygen containing heterocycles that have a strong neuroprotective behavior, inhibiting several of the important events involved in the AD process. In this review, an approach is presented that relies on expanding the neuroprotective chemical space of benzofuran scaffolds by accessing them from Andean-Patagonian fungi and synthetic sources (chemical libraries). The exploration of the neuroprotective chemical space of these scaffolds has the potential to allow the discovery of substitution patterns that display multi-target neuroactivity against multiple events involved in AD. This benzofuran chemical framework will establish a multi-target chemical space that could set the basis for the development of super drugs against AD.

Synthetic Route of 497-23-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, in an article , author is Xu, Kai, once mentioned of 497-23-4, Recommanded Product: Furan-2(5H)-one.

Design, Synthesis, and Anticancer Activities of Benzofuran-Isatin Hybrids Tethered by Pentylene and Hexylene

Fourteen benzofuran-isatin hybrids 6a-f and 7a-h tethered via alkyl linker (pentylene and hexylene) were designed and synthesized, and hybrids 6c-f and 7a-h were screened for their in vitro anticancer activity against various human cancer cell lines. The majority of the hybrids were active against the tested cancer cells, and the most active hybrids 7g (half maximal inhibitory concentration/IC50: 77.2-88.9 mu M) and 7h (IC50: 65.4-89.7 mu M), which possessed broad spectrum anticancer activity were as potent as the reference vorinostat (IC50: 64.2->100 mu M) against all tested cancer cell lines, could act as leads for further investigations. The structure-activity relationship is also discussed, and the enriched structure-activity relationship may afford useful information for further rational design of the candidates with higher activity.

Interested yet? Read on for other articles about 497-23-4, you can contact me at any time and look forward to more communication. Recommanded Product: Furan-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 66357-35-5, Name is Ranitidine, formurla is C13H22N4O3S. In a document, author is Kim, Yoon-Jung, introducing its new discovery. Category: benzofurans.

Benzo[b]tellurophenes as a Potential Histone H3 Lysine 9 Demethylase (KDM4) Inhibitor

Gene expression and tumor growth can be regulated by methylation levels of lysine residues on histones, which are controlled by histone lysine demethylases (KDMs). Series of benzo[b]tellurophene and benzo[b]selenophene compounds were designed and synthesized and they were evaluated for histone H3 lysine 9 demethylase (KDM4) inhibitory activity. Among the carbamates, alcohol and aromatic derivatives, tert-butyl benzo[b]tellurophen-2-ylmethylcarbamate (compound 1c) revealed KDM4 specific inhibitory activity in cervical cancer HeLa cells, whereas the corresponding selenium or oxygen substitute compounds did not display any inhibitory activity toward KDM4. Compound 1c also induced cell death in cervical and colon cancer but not in normal cells. Thus, compound 1c, a novel inhibitor of KDM4, constitutes a potential therapeutic and research tool against cancer.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 66357-35-5 help many people in the next few years. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is C5H6O2, belongs to benzofurans compound. In a document, author is Li, Yong, introduce the new discover, Product Details of 591-11-7.

Design, Synthesis and Antifungal Activities of 6-Substituted 3-Butylphthalide Derivatives against Phytopathogenic Fungi

In order to discover novel potential antifungal agents, a series of 6-substituted 3-butylphthalide derivatives were designed, synthesized and evaluated for their antifungal activities against nine phytopathogenic fungi. Preliminary bioassay tests showed that five 3-butylphthalide derivatives exhibited more potent antifungal activities than hymexazol at the concentration of 50 mu g/mL. Especially, 3-butyl-6-nitro-2-benzofuran-1(3H)-one and 3-butyl-6-hydroxy-5-nitro-2-benzofuran-1(3H)-one had significant fungicidal activity against some phytopathogenic fungi. The EC(50)of 3-butyl-6-nitro-2-benzofuran-1(3H)-one against FS, FO and FG were 6.6, 9.6 and 16.0 mu g/mL, respectively. The EC(50)of 3-butyl-6-hydroxy-5-nitro-2-benzofuran-1(3H)-one against BC, PO, VM, SS and AS were 6.3, 5.9, 10.0, 4.5 and 8.4 mu g/mL, respectively. The preliminary structure-activity relationships (SARs) of all target compounds were also investigated.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 591-11-7. Product Details of 591-11-7.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem