Category: benzofurans

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 4412-91-3, Name is 3-Furanmethanol, molecular formula is , belongs to benzofurans compound. In a document, author is Anbar, Hanan S., Name: 3-Furanmethanol.

Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents

Ectonucleotidases are a broad family of ectoenzymes that play a crucial role in purinergic cell signaling. Ectonucleotide pyrophosphatases/phosphodiesterases (NPPs) belong to this group and are important drug targets. In particular, NPP1 and NPP3 are known to be druggable targets for treatment of impaired calcification disorders (including pathological aortic calcification) and cancer, respectively. In this study, we investigated a series of sulfonate and sulfamate derivatives of benzofuran and benzothiophene as potent and selective inhibitors of NPP1 and NPP3. Compounds 1c, 1g, 1n, and 1s are the most active NPP1 inhibitors (IC50 values in the range 0.12-0.95 mu M). Moreover, compounds 1e, 1f, 1j, and 1l are the most potent inhibitors of NPP3 (IC50 ranges from 0.12 to 0.95 mu M). Compound 1d, 1f and 1t are highly selective inhibitors of NPP1 over NPP3, whereas compounds 1m and 1s are found to be highly selective towards NPP3 over NPP1. Structure-activity relationship (SAR) study has been discussed in detailed. With the aid of molecular docking studies, a common binding mode of these compounds and suramin (the standard inhibitor) was revealed, where the sulfonate group acts as a cation-binding moiety that comes in close contact with the zinc ion of the active site. Moreover, cytotoxic evaluation against MCF-7 and HT-29 cancer cell lines revealed that compound 1r is the most cytotoxic towards MCF-7 cell line with IC50 value of 0.19 mu M. Compound 1r is more potent and selective against cancer cells than normal cells (WI-38) as compared to doxorubicin.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4412-91-3, in my other articles. Name: 3-Furanmethanol.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 5-Methylfuran-2(5H)-one591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a article, author is Ezzatzadeh, Elham, introduce new discover of the category.

Green synthesis and antioxidant activity of novel series of benzofurans from euparin extracted of Petasites hybridus

A novel class of benzofuran derivatives is prepared from the isocyanide-based MCR, euparin and aldehydes in the presence of ZnO-nanorods as a catalyst in excellent yields at room temperature under solvent-free conditions as a green reaction medium. Also, the antioxidant activities of some synthesised compounds such as 4a, 4b, 10a and 10b were evaluated by DPPH radical scavenging and ferric reduction activity potential (FRAP) assays. Compound 10b, was shown moderate radical scavenging activity and very good reducing activity compared to standards (BHT and TBHQ). [GRAPHICS] .

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 591-11-7. Recommanded Product: 5-Methylfuran-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Li, Yang,once mentioned of 497-23-4, Safety of Furan-2(5H)-one.

Application of 2,4-bis(halomethyl)quinoline: synthesis and biological activities of 2,4-bis(benzofuran-2-yl)- and 2,4-bis(aroxymethyl)quinolines

In the present investigation, the synthesis of a new type of halomethylquinoline building block, i.e., ethyl 4-(bromomethyl)-2-(chloromethyl)quinoline-3-carboxylate, and its synthetic applications in the reaction with salicylaldehydes or phenols to make a range of structurally novel and intriguing 2,4-bis(benzofuran-2-yl)quinoline- and 2,4-bis(aroxymethyl)quinoline-3-carboxylic acids is described. Our newly synthesized compounds belong to a new class of quinoline derivatives, and their structures were elucidated on the basis of their spectral data and elemental analyses. Screening for in vitro anti-tubercular against Mycobacterium smegmatis and anti-bacterial activities against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was carried out. Compounds 5e and 5g showed significant anti-tubercular activity comparable with the reference rifampicin and might be used as promising candidates for further investigation. [GRAPHICS] .

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4. In an article, author is Bao, Xiaoze,once mentioned of 97148-39-5, Name: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

Bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal C-C stereogenic axes

We report the bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal C-C stereogenic axes obtained by a two-fold central-to-axial chirality conversion upon oxidative aromatization. The key enantioenriched centrally chiral bis-dihydrobenzofuran precursors were synthesized via a bidirectional diastereo- and enantio-selective organocatalyzed domino reaction between simple achiral and easily accessible dihydroxylated aromatics and chloronitroalkenes. Moreover, the stereodivergent nature of the methodology was established by synthesizing both diastereomers of a non-symmetrically functionalized bis-axially chiral oligoarene.

Interested yet? Keep reading other articles of 97148-39-5, you can contact me at any time and look forward to more communication. Name: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, in an article , author is Zhao, Chao, once mentioned of 174775-48-5, Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate.

Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A

Protein kinases play an indispensable role in signaling pathways that regulate tumor cell functions, which represent potent therapeutic targets in cancers. Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) as a serine/threonine kinase has recently been reported to be upregulated in pancreatic ductal adenocarcinoma (PDAC) and show protumorigenic effect. By activity-guided phytochemical investigation of the extracts from Glycyrrhiza uralensis Fisch, we expect to find the effective constituents that can suppress pancreatic cancer cell proliferation and/or induce cells apoptotic by inhibiting DYRK1A. Eight isopentenyl-substituted compounds (1-8), including four coumarins (1-4), one benzofuran (5), and three flavonoids (6-8), were isolated and identified from G. uralensis Fisch. Among them, licocoumarone (LC, 5) showed effective inhibitory activity against DYRK1A with an IC50 value of 12.56 mu M. Molecular docking analysis suggested that LC completely occupied the whole pocket of DYRK1A and formed obvious hydrophobic interactions and hydrogen bonds with DYRK1A residues. Further in vitro validation, including Microscale Thermophoresis (MST) and drug affinity responsive target stability (DARTS) techniques, demonstrated the specific combining capacity of LC to DYRK1A. Meanwhile, LC induced significant cytotoxicity against DYRK1A-overexpressing BxPC-3 cells with an IC50 value of 50.77 mu M. Mechanism studies revealed that LC reduced c-MET protein level by inhibiting DYRK1A. These findings provide preliminary evidences that LC as a natural DYRK1A inhibitor suppresses human pancreatic adenocarcinoma BxPC-3 cell proliferation and induces cell apoptotic, which might present new options and possibilities for targeted therapies in pancreatic cancer therapy.

Interested yet? Read on for other articles about 174775-48-5, you can contact me at any time and look forward to more communication. Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Maridevarmath, C., V, once mentioned the application of 14400-67-0, COA of Formula: C6H8O2, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category.

Synthesis, characterization and photophysical studies on novel benzofuran-3-acetic acid hydrazide derivatives by solvatochromic and computational methods

In the present studies, synthesis of two novel benzofuran-3-acetic acid hydrazide derivatives namely, (6-methyl-benzofuran-3-yl)-acetic acid hydrazide [6MLBH] and (6-methoxy-benzofuran-3-yl)-acetic acid hydrazide [6MOBH] are reported. The probes are characterized by IR, H-1-NMR, C-13-NMR and mass spectral methods. The absorption and fluorescence maxima of novel derivatives 6MLBH and 6MOBH are determined for different solvents of varying polarity and the solvatochromic behavior and dipole moments are investigated. Stoke’s shift exhibits a red shift with increase in solvent polarity for both the probe molecules indicating a pi ->pi* transition. The ground state dipole moment (mu g) of both the molecules in gaseous phase is estimated from ab initio computations by using Gaussian 09 W software and also from solvatochromic method and the results are compared. Further, the ground state dipole moments of the probe molecules in different solvents were also estimated theoretically by using the integral equation formalism of polarizable continuum model (IEF-PCM). By using solvatochromic correlations like Lippert’s, Bakhshiev’s, Kawski-Chamma-Viallet’s and solvent polarity parameter (E-T(N)), the excited state dipole moments (mu(e)) are determined. Results show that, the excited state dipole moments (mu(e)) are higher than the ground state dipole moments (mu g) and suggest that, the probe molecules 6MLBH and 6MOBH are more polar in the excited state. The HOMO-LUMO energy gaps computed from density functional theory (DFT) and from absorption threshold wavelengths are found to be in agreement and also support intramolecular charge transfer (ICT). Using HOMO-LUMO energies, the chemical hardness (eta) of the molecules are determined and the chemical stability is discussed. Further, using DFT molecular electrostatic potential (MESP) plots, the electrophilic site and nucleophilic site which are useful in photochemical reactions were identified. The various types of interactions present between the solute-solvent were analyzed by multiple linear regression analysis using Catalan parameters. The preliminary observations and results suggest that, the probe molecules 6MLBH and 6MOBH can be considered as potential candidates for luminescence materials, fluorescent probes and for designing non-linear optical materials in future. (C) 2019 Elsevier B.V. All rights reserved.

If you are interested in 14400-67-0, you can contact me at any time and look forward to more communication. COA of Formula: C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2. In an article, author is Song, Zhi-Qiang,once mentioned of 4412-91-3, Formula: C5H6O2.

Palladium-Catalyzed Hydroxylation of Aryl Halides with Boric Acid

Boric acid, B(OH)(3), is proved to be an efficient hydroxide reagent in converting (hetero)aryl halides to the corresponding phenols with a Pd catalyst under mild conditions. Various phenol products were obtained in good to excellent yields. This transformation tolerates a broad range of functional groups and molecules, including base-sensitive substituents and complicated pharmaceutical (hetero)aryl halide molecules.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 4412-91-3, you can contact me at any time and look forward to more communication. Formula: C5H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Reference of 497-23-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Abdelfatah, Sara, introduce new discover of the category.

MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1 PBD was confirmed using fluorescence polarization and microscale thermophoresis. This compound exerted specificity towards PLK1 over PLK2 and PLK3. MCC1019 showed cytotoxic activity in a panel of different cancer cell lines. Mechanistic investigations in A549 lung adenocarcinoma cells revealed that MCC1019 induced cell growth inhibition through inactivation of AKT signaling pathway, it also induced prolonged mitotic arrest-a phenomenon known as mitotic catastrophe, which is followed by immediate cell death via apoptosis and necroptosis. MCC1019 significantly inhibited tumor growth in vivo in a murine lung cancer model without affecting body weight or vital organ size, and reduced the growth of metastatic lesions in the lung. We propose MCC1019 as promising anti-cancer drug candidate. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Reference of 497-23-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, in an article , author is Abdel-Aziem, Anhar, once mentioned of 497-23-4, COA of Formula: C4H4O2.

Eco-Friendly Synthesis of 3-Aryl-2,3-dihydro-1,3,4-thiadiazoles Based on Benzofuran and Chromone Moieties

In consideration of green and efficient organic chemical methodology, we reported here a green, an efficient and convenient procedure for synthesis of 3-aryl-2,3-dihydro-1,3,4-thiadiazoles based on benzofuran as well as chromone moieties, using the grinding technique. Condensation of 1-(4,7-dimethoxybenzofuran-5-yl)ethan-1-ones 2, 3; 7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-carbaldehyde (4); and 4-oxo-4H-chromene-3-carbaldehydes 10a-c with alkyl hydrazine carbodithioates followed with some hydrazonoyl halides 7a-g under grinding and solvent-free condition led to the formation of the targeted 3-aryl-2,3-dihydro-1,3,4-thiadiazoles 8a-g, 9a,b, and 12a-f, correspondingly. Structures of the synthesized compounds were clarified based on their elemental analyses and spectral data. Eleven of the entire target compounds were selected for anticancer activity against 60 human cancer cell lines at a single dose (10?(5) M) by the National Cancer Institute (NCI, Bethesda, USA).

Interested yet? Read on for other articles about 497-23-4, you can contact me at any time and look forward to more communication. COA of Formula: C4H4O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Formula: C8H6O2, 87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, in an article , author is Wang, Xunchang, once mentioned of 87-41-2.

Terpolymer Strategy toward High-Efficiency Polymer Solar Cells: Integrating Symmetric Benzodithiophene and Asymmetrical Thieno[2,3-f]benzofuran Segments

While a large number of terpolymers have been developed for polymer solar cells, very few studies have directly focused on the rational selection of the third component to balance the miscibility and crystallinity for forming the desired morphology, and universal terpolymer strategies for preparing different donor/acceptor systems are lacking. Herein, we employ a new strategy involving the integration of benzodithiophene (BDT) and thieno [2,3-f ]benzofuran (TBF) segments to construct a series of terpolymer donors, and a profound influence on the crystallinity and miscibility of the blend films as well as on the ultimate device performance is observed. Incorporating highly crystalline TBF segments into a low-crystalline BDT-based alternating copolymer can not only increase the order of the microstructure, conserve the favorable face-on orientation, and promote the formation of proper phase-separation features but also generate high exciton dissociation and suppress charge recombination. This strategy was successfully applied in the reported J52 system and provided a remarkable 2-fold boost in performance. Finally, competitive power conversion efficiencies of 11.9, 12.4, and 12.2% accompanied by high fill factors of 73, 71, and 76% were recorded for TBFC150-FTAZ/ITIC-, TBFC150-BDD/ITIC-, and TBFC150-BDD/IDIC-C4Ph-based devices, respectively, via the above terpolymer strategy. Thus, our discovery provides a promising and innovative method for finely controlling the microstructure of heterojunctions for designing high-performance terpolymers.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 87-41-2, you can contact me at any time and look forward to more communication. Formula: C8H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem