Category: benzofurans

Recently I am researching about REAGENTS; FUNCTIONALIZATION; REACTIVITY; CHEMISTRY, Saw an article supported by the Ministry of Education, Culture, Sports, Science and Technology of JapanMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [G19K05469]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Nishiguchi, Y; Moriyama, K. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Recommanded Product: 87-41-2

We developed a method for the preparation of (diacetoxyiodo)-2-(N-alkylamido)benzene as an aniline-type hypervalent iodine(III). We also achieved direct cyclizations via C-H bond abstraction, such as the Hofmann-Loffler-Freytag reaction, a direct amination, and a direct lactonization, using the aniline-type hypervalent iodine(III) to obtain corresponding products in high yields.

Recommanded Product: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Nishiguchi, Y; Moriyama, K or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. Pan, YL; Zheng, HL; Wang, J; Yang, C; Li, X; Cheng, JP in [Pan, Yu-Liang; Zheng, Han-Liang; Wang, Jie; Yang, Chen; Li, Xin; Cheng, Jin-Pei] Nankai Univ, State Key Lab Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China published Enantioselective Allylation of Oxocarbenium Ions Catalyzed by Bi(OAc)(3)/Chiral Phosphoric Acid in 2020, Cited 81. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Phthalides as the crucial core skeletons are found extensively in natural products and biological active molecules. Herein we disclose an asymmetric allylation of 3-hydroxyisoben-zofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives. The simple Bi(OAc)(3)/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biological activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Pan, YL; Zheng, HL; Wang, J; Yang, C; Li, X; Cheng, JP or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about ENANTIOSELECTIVE SYNTHESIS; ORGANOCATALYSTS; BOND; 1,3-DIHYDROISOBENZOFURANS; STRATEGY; CASCADE, Saw an article supported by the National Research Foundation of KoreaNational Research Foundation of Korea [NRF-2020R1A2C1005438]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Son, EC; Kim, SY; Kim, SG. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. COA of Formula: C8H6O2

Organocatalytic enantioselective intramolecular oxa-Michael reactions of benzyl alcohol bearing alpha,beta-unsaturated carbonyls as Michael acceptors are presented herein. Using cinchona squaramide-based organocatalyst, enones as well as alpha,beta-unsaturated esters containing benzyl alcohol provided their corresponding 1,3-dihydroisobenzofuranyl-1-methylene ketones and 1,3-dihydroisobenzofuranyl-1-methylene esters in excellent yields with high enantioselectivities. In addition, enantioenriched 1,3-dihydroisobenzofuranyl-1-methylene ketone could be obtained from the Wittig/oxa-Michael reaction cascade of 1,3-dihydro-2-benzofuran-1-ol.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Son, EC; Kim, SY; Kim, SG or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR in [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, West China Sch Pharm,Dept Pharmacol,Sichuan Engn, Chengdu 610041, Peoples R China; [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Sichuan Prov Key Lab Qual & Innovat Res Chinese M, Chengdu 610041, Peoples R China; [Duan, Wei] Deakin Univ, Sch Med, Waurn Ponds, Vic, Australia; [Duan, Wei] Deakin Univ, Ctr Mol & Med Res, Waurn Ponds, Vic, Australia; [Yang, Yu-Xin] PRIVIS TECHNOL CO LTD, Chengdu 610041, Peoples R China published Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation in 2020, Cited 47. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR or concate me.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. I found the field of Chemistry very interesting. Saw the article Formates plus triazabicyclodecene (TBD): an efficient platform for non-gaseous carbonylation and unexpected hydrogenation published in 2019, Reprint Addresses Zhou, HW (corresponding author), Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

A highly efficient palladium-catalyzed TBD-formate system for carbonylation/hydrogenation was reported. Based on the obvious solvent effect and reasonable mechanism study, we achieved tunable carbonylation or hydrogenation. With the advantages of simple operation, mild conditions and storable reagents, this protocol should be of interest not only for synthetic scientists but also helpful for laboratory operators.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Chen, DP; Yao, JZ; Chen, LL; Hu, LF; Li, XF; Zhou, HW or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Category: benzofurans. I found the field of Chemistry very interesting. Saw the article Tunable pH-sensitive 2-carboxybenzyl phosphoramidate cleavable linkers published in 2020, Reprint Addresses Berkman, CE (corresponding author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pK(a) of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pK(a) of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values. (C) 2020 Elsevier Ltd. All rights reserved.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE or concate me.. Category: benzofurans

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 PHYS CHEM CHEM PHYS published article about OXIDATIVE DEHYDROGENATION; CARBON NANOTUBES; LIQUID-PHASE; EFFICIENT; GRAPHENE; HYDROGENATION; CARBOCATALYST; NITROARENES; OXIDE; BN in [Wu, Shuchang] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Zhejiang, Peoples R China; [Lin, Yangming; Wen, Guodong; Liu, Hongyang; Su, Dang Sheng] Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China; [Zhong, Bingwei] Zhejiang A&F Univ, JiYang Coll, 77 Puyang Rd, Zhuji 311800, Peoples R China in 2019, Cited 28. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

A zigzag-type quinone performs better than an armchair-type quinone in the reduction of nitrobenzene. When different kinds of functionalities co-exist, the reaction is dominated by the most active sites, but the most negative sites should also be taken into consideration if the acitive sites have zigzag structures.

Category: benzofurans. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wu, SC; Lin, YM; Zhong, BW; Wen, GD; Liu, HY; Su, DS or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. In 2020 CHEM ENG RES DES published article about THERMAL-CONDUCTIVITY; HEAT-TRANSFER; SIMULATION; FLOW; TRANSPORT in [Dixon, Anthony G.; Wu, Yan] Worcester Polytech Inst, Dept Chem Engn, 100 Inst Rd, Worcester, MA 01609 USA in 2020, Cited 37. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The present study analyses the thermowell system for monitoring temperatures in a fixed bed catalytic reactor for the highly exothermic partial oxidation of o-xylene to phthalic anhydride. Particle-resolved computational fluid dynamics (CFD) simulations are presented for the cases of randomly-packed spheres inside cylindrical tubes with tube-to-particle diameter ratios (N) of 3.96, 5.96 and 7.99. Results are obtained for each N value for cases with inner thermowell radius to outer tube radius ratios of 0.0 (no thermowell), 0.05, 0.1 and 0.2. Comparisons of radial void fraction and axial velocity profiles, axial pressure drop and axial temperature profiles under reaction conditions are presented. The presence of the thermowell did change the mass and heat transfer and reaction inside and around the particles, especially at the bed center. The configurations of catalyst particles were rearranged, leading to changes in voidage, flow and temperature profile. The axial temperature profiles from the thermowells differed from the profiles in the undisturbed beds. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Dixon, AG; Wu, Y or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Patil, A; Duggal, H; Bagul, KT; Kamble, S; Lokhande, P; Gacche, R; Meshram, R in BENTHAM SCIENCE PUBL LTD published article about BIFUNCTIONAL DCTP DEAMINASE; DRUG TARGET IDENTIFICATION; MYCOBACTERIUM-TUBERCULOSIS; FORCE-FIELD; ESCHERICHIA-COLI; WEB SERVER; DERIVATIVES; INHIBITORS; DUTPASE; SUSCEPTIBILITY in [Patil, Avinash; Duggal, Harleen; Bagul, Kamini T.; Lokhande, Pradeep; Meshram, Rohan] Savitribai Phule Pune Univ, Dept Chem, Pune, Maharashtra, India; [Duggal, Harleen; Bagul, Kamini T.; Meshram, Rohan] Savitribai Phule Pune Univ, Bioinformat Ctr, Dept Biotechnol, Pune, Maharashtra, India; [Kamble, Sonali] Gramin Sci Vocat Coll, Vishnupuri, Nanded, India; [Gacche, Rajesh] Savitribai Phule Pune Univ, Dept Biotechnol, Pune, Maharashtra, India in 2020, Cited 73. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Objective: The study aims at the derivatization of Phthalides and synthesizes 3-arylaminophthalides & 3-indolyl-phthalides compounds, and evaluates their anti-tubercular and antioxidant activities. The study has also intended to employ the in silica methods for the identification of possible drug targets in Mycobacterium and evaluate the binding affinities of synthesized compounds. Methods: This report briefly explains the synthesis of phthalide derivatives using ammonium chloride. The synthesized compounds were characterized using spectral analysis. Resazurin Microtiter Assay (REMA) plate method was used to demonstrate the anti-mycobacterial activity of the synthesized compounds. An in-silico pharmacophore probing approach was used for target identification in Mycobacterium. The structural level interaction between the identified putative drug target and synthesized phthalides was studied using Lamarckian genetic algorithm-based software. Results and Discussion: In the present study, we report an effective, environmentally benign scheme for the synthesis of phthalide derivatives. Compounds 5c and 5d from the current series appear to possess good anti-mycobacterial activity. dCTP: deaminasedUTPase was identified as a putative drug target in Mycobacterium. The docking results clearly showed the interactive involvement of conserved residues of dCTP with the synthesized phthalide compounds. Conclusion: On the eve of evolving anti-TB drug resistance, the data on anti-tubercular and allied activities of the compounds in the present study demonstrates the enormous significance of these newly synthesized derivatives as possible candidate leads in the development of novel anti-tubercular agents. The docking results from the current report provide a structural rationale for the promising anti-tubercular activity demonstrated by 3-arylaminophthalides and 3-indolyl-phthalides compounds.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Patil, A; Duggal, H; Bagul, KT; Kamble, S; Lokhande, P; Gacche, R; Meshram, R or concate me.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 J CLEAN PROD published article about ADVANCED OXIDATION PROCESSES; AQUEOUS-SOLUTION; WASTE-WATER; PHOTOCHEMICAL DEGRADATION; HYDROXYL RADICALS; HYDROGEN-PEROXIDE; AZO-DYE; MECHANISM; REMOVAL; KINETICS in [Lu, Chao; Yao, Jun; Amde, Meseret; Gu, Jihai; Liu, Jianli; Li, Hao] China Univ Geosci Beijing, Res Ctr Environm Sci & Engn, Sch Water Resource & Environm, 29 Xueyuan Rd, Beijing 100083, Peoples R China; [Knudsen, Tatjana Solevic] Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia; [Amde, Meseret] Haramaya Univ, Coll Nat & Computat Sci, Dept Chem, POB 138, Dire Dawa, Ethiopia; [Zhang, Junyang] Curtin Univ, Western Australia Sch Mines, Dept Min & Met Engn, Kalgoorlie, WA, Australia in 2019, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Product Details of 87-41-2

Flotation reagents, especially new chelating agents represented by alpha-nitroso-beta-naphthol, are the main components of cobalt mining drainage. This study reports the degradation of alpha-nitroso-beta-naphthol by simulated UVA-B (280-400 nm) activated systems using three common oxidants, hydrogen peroxide, sodium persulfate and potassium monopersulfate at a laboratory scale using a photoreactor. Parameters which can affect the degradation process were investigated and comparison of the degradation performance of the three systems were made. Based on the results, UVA-B/sodium persulfate system exhibited best performance towards the removal of alpha-nitroso-beta-naphthol with a lower cost of oxidant and energy consumption compared to the others. The removal efficiency was found to increase as the oxidant dosage and the UVA-B power increases. Only potassium monopersulfate could be activated by bicarbonate and chloride ions, and SO42- has insignificant effect on the removal efficiency of alpha-nitroso-beta-naphthol for all systems while NO3- inhibited the degradation of alpha-nitroso-beta-naphthol. In the UVA-B/hydrogen peroxide system, the hydroxyl radical had a leading role in the degradation of alpha-nitroso-beta-naphthol, while in the other two systems, the degradation of alpha-nitroso-beta-naphthol was mainly caused by the hydroxyl and sulphate radicals. Ten major intermediates from alpha-nitroso-beta-naphthol degradation in the three oxidation systems were identified by gas chromatography and mass spectrometry. In summary, this report could be a great input in developing UVA-B activated oxidants-based treatment technologies. The UVA-B/sodium persulfate system is strongly recommended for its consideration in the treatment of mine impacted wastewaters. (c) 2019 Elsevier Ltd. All rights reserved.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lu, C; Yao, J; Knudsen, TS; Amde, M; Gu, JH; Liu, JL; Li, H; Zhang, JY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem