Category: benzofurans

I found the field of Chemistry very interesting. Saw the article Catalytic reductive deoxygenation of esters to ethers driven by hydrosilane activation through non-covalent interactions with a fluorinated borate salt published in 2020. Name: Isobenzofuran-1(3H)-one, Reprint Addresses Michon, C (corresponding author), Univ Lille, Univ Artois, UMR 8181 UCCS Unite Catalyse & Chim Solide, Cent Lille,CNRS, F-59000 Lille, France.; Vanka, K (corresponding author), Natl Chem Lab, Phys & Mat Chem Div, CSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India.; Michon, C (corresponding author), Univ Strasbourg, Univ Haute Alsace, Ecole Europeenne Chim Polymeres & Mat, CNRS,LIMA,UMR 7042, 25 Rue Becquerel, F-67087 Strasbourg, France.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

We report the catalytic and transition metal-free reductive deoxygenation of esters to ethers through the use of a hydrosilane and a fluorinated borate BArF salt as a catalyst. Experimental and theoretical studies support the role of noncovalent interactions between the fluorinated catalyst, the hydrosilane and the ester substrate in the reaction mechanism.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Rysak, V; Dixit, R; Trivelli, X; Merle, N; Agbossou-Niedercorn, F; Vanka, K; Michon, C or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo published in 2020. Application In Synthesis of Isobenzofuran-1(3H)-one, Reprint Addresses Liu, XH (corresponding author), Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China.; Ruan, BF (corresponding author), Hefei Univ, Key Lab Biofabricat Anhui Higher Educ, Hefei 230601, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalide is a promising chemical scaffold and has been proved to show potent anti-inflammatory efficacy. In this study, three series, total of 31 novel phthalide derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. The anti-inflammatory activity of all the compounds were screened on LPS induced NO production to evaluating their inhibitory effects. Structure-activity relationship has been concluded, and finally 3-((4-((4-ufluorobenzyl)oxy)phenyl)(-hydroxy)methyl)-5,7-dimethoxyisobenzofuran-1 (3H)-one (compound 9o) was found to be the active one with low toxicity, which showed 95.23% inhibitory rate at 10 mu M with IC50 value of 0.76 mu M against LPS-induced NO over expression. Preliminary mechanism studies indicated that compound 9o activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-kappa B/MAPK signaling pathway. The in vivo anti-inflammatory activity shown that compound 90 had obvious therapeutic effect against the adjuvant-induced rat arthritis model. (C) 2020 Elsevier Masson SAS. All rights reserved.

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 CHEMCATCHEM published article about 1,10-PHENANTHROLINE COMPLEXES; PHOTOOXIDATION; MECHANISM; NITRATE; LIGNIN in [Arnold, Polly L.; Purkis, Jamie M.; Rutkauskaite, Ryte; Love, Jason B.] Univ Edinburgh, EaStCHEM Sch Chem, Joseph Black Bldg, Edinburgh EH9 3FJ, Midlothian, Scotland; [Kovacs, Daniel] Uppsala Univ, Angstromslab, Lagerhyddsvagen 1, S-75237 Uppsala, Sweden; [Austin, Jonathan] Natl Nucl Lab, 5th Floor,Chadwick House,Birchwood Pk, Warrington WA3 6AE, Cheshire, England in 2019, Cited 33. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: Isobenzofuran-1(3H)-one

Controlled, photocatalytic C-H bond activations are key reactions in the toolkits of the modern synthetic chemist. While it is known that the uranyl(VI) ion, [(UO2)-O-VI](2+), the environmentally dominant form of uranium, is photoactive, most literature examines its luminescent properties, neglecting its potential synthetic utility for photocatalytic C-H bond cleavage. Here, we synthesise and fully characterise an air-stable and hydrocarbon-soluble uranyl phenanthroline complex, [(UO2)-O-VI(NO3)(2)(Ph(2)phen)], U-Ph2phen, and demonstrate that it can catalytically abstract hydrogen atoms from a variety of organic substrates under visible light irradiation. We show that the commercially available parent complex, uranyl nitrate ([(UO2)-O-VI(NO3)(2)(OH2)(2)]center dot 4H(2)O; U-NO3), is also competent, but from electronic spectroscopy we attribute the higher rates and selectivity of U-Ph2phen to ligand-mediated electronic effects. Ketones are selectively formed over other oxygenated products (alcohols, etc.), and the catalytic oxidation of substrates containing a benzylic C-H position is particularly improved for U-Ph2phen. We also show uranyl-mediated photocatalytic C-C bond cleavage in a model lignin compound for the first time.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Arnold, PL; Purkis, JM; Rutkauskaite, R; Kovacs, D; Love, JB; Austin, J or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Peroxydisulfate-Mediated Transition-Metal-Free Oxidative C(sp(3))-H Bond Lactonization published in 2019. Computed Properties of C8H6O2, Reprint Addresses Nozawa-Kumada, K; Kondo, Y (corresponding author), Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, 6-3 Aoba, Sendai, Miyagi 9808578, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

An inexpensive, powerful, and eco-friendly method for transition-metal-free oxidative C(sp(3))-H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2-alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives. Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Nozawa-Kumada, K; Kurosu, S; Shigeno, M; Kondo, Y or concate me.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C in [Zhang, Qiaohong; He, Honghao; Wang, Huibin; Chen, Chen] Ningbo Univ, Sch Mat Sci & Chem Engn, 818 Fenghua Rd, Ningbo 315211, Peoples R China; [Zhang, Zhan] China Tobacco Henan Ind Co Ltd, 8 3rd Ave, Zhengzhou 450001, Peoples R China published Efficient catalytic oxidation of methyl aromatic hydrocarbon with N-alkyl pyridinium salts in 2019, Cited 47. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A series of N-alkyl pyridinium salts were synthesized and employed as metal-free catalyst for the selective oxidation of methyl aromatic hydrocarbon with molecular oxygen. The electronic effect of the substitutes was found to be an important factor for the catalytic performance. With the introduction of electron-donating substitute -N(CH3)(2), the conversion of p-xylene and selectivity of p-toluic acid could be simultaneously increased. 1-Benzyl-4-N,N-dimethylaminopyridinium salt showed the highest catalytic activity, and 95% conversion with 84% of selectivity to p-toluic acid could be obtained for the selective oxidation of p-xylene. Several methyl aromatic hydrocarbons could all be efficiently oxidized with the reported catalyst at the absence of any metal species.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Antimicrobial drimane – phthalide derivatives from Hypoxylon fendleri BCC32408 WOS:000498290700028 published article about RESAZURIN in [Intaraudom, Chakapong; Bunbamrung, Nantiya; Dramae, Aibrohim; Boonruangprapa, Tanapong; Pittayakhajonwut, Pattama] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathum Thani, Thailand; [Punyain, Wikorn] Naresuan Univ, Fac Sci, Dept Chem, Phitsanulok 65000, Thailand in 2019, Cited 12. Recommanded Product: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P or concate me.. Recommanded Product: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen WOS:000486072800012 published article about AEROBIC OXIDATION; DEHYDROGENATIVE LACTONIZATION; PALLADIUM NANOPARTICLES; ALCOHOLS; EFFICIENT; HYDROXIDE; 1,4-DIOLS; LACTONES; BEARING in [Takakura, Ryoya; Ban, Kazuho; Sajiki, Hironao; Sawama, Yoshinari] Gifu Pharmaceut Univ, Lab Organ Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan in 2019, Cited 49. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Name: Isobenzofuran-1(3H)-one

A lactonization of various diols catalyzed by platinum on carbon (Pt/C) in water under an atmosphere of molecular oxygen was developed. Derivatives of 1,4- 1,5- and 1,6-diols were transformed into the corresponding five-, six-, and seven-membered lactones by the present oxidative lactonization method.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Takakura, R; Ban, K; Sajiki, H; Sawama, Y or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 CHEMOSPHERE published article about POLYCYCLIC AROMATIC-HYDROCARBONS; PHOTOLYSIS HALF-LIVES; SPIRIT OIL-SPILL; CRUDE-OIL; AQUEOUS PHOTODEGRADATION; PHOTOCATALYTIC DEGRADATION; UV-LIGHT; TOXICITY; PAHS; SEDIMENTS in [Kang, Hyun-Joong; Jung, Yerin; Kwon, Jung-Hwan] Korea Univ, Div Environm Sci & Ecol Engn, 145 Anam Ro, Seoul 02841, South Korea in 2019, Cited 65. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

Crude oil released into the environment contains many polycyclic aromatic hydrocarbons (PAHs). Alkylated PAHs are more abundant than unsubstituted PAHs and their toxicity is also of serious concern. Among the various physical, chemical, and biological weathering processes of crude oils, photodegradation is one of the most important for determining the environmental fate of oil residues. In this study, the photodegradation rate constants of naphthalene and alkylated naphthalenes were determined under simulated laboratory conditions at different temperature. Changes in the luminescence inhibition of Aliivibrio fischeri, as an indicator of the baseline toxicity, were observed in photodegradation mixtures. The major transformation products were also identified by gas chromatography-mass spectrometry. The photodegradation of naphthalene and the eight alkylated naphthalenes was described well by pseudofirst-order kinetics regardless of experimental temperature. The measured toxicity of the reaction mixtures obtained by photodegradative weathering slightly increased initially and then decreased with further weathering. In all cases, the observed toxicity was greater than accounted for by the parent compounds, indicating that the photodegradation products also contributed significantly to the overall toxicity of the mixtures. The identified photodegradation products were mostly oxygenated compounds such as alcohols, aldehydes, ketones, and quinones, which warrant further investigation. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Kang, HJ; Jung, Y; Kwon, JH or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about C-H BONDS; CATALYZED BORYLATION; PHOTOINDUCED BORYLATION; ORGANOBORON CHEMISTRY; N-TOSYLHYDRAZONES; ADDITIVE-FREE; ESTERS; EFFICIENT; CARBON; FUNCTIONALIZATION, Saw an article supported by the Canada Research Chair FoundationCanada Research Chairs; Canada Foundation for InnovationCanada Foundation for InnovationCGIAR; FQRNT Center in Green Chemistry and CatalysisFQRNT; Natural Sciences and Engineering Research Council of CanadaNatural Sciences and Engineering Research Council of Canada (NSERC)CGIAR; McGill University. Recommanded Product: Isobenzofuran-1(3H)-one. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Li, JB; Wang, HN; Qiu, ZH; Huang, CY; Li, CJ. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Direct conversion of aldehydes and ketones into alkylboronic esters via deoxygenative borylation represents an unknown yet highly desirable transformation. Herein, we present a one-step and metal-free method for carbonyl deoxy-borylation under mild conditions. A wide range of aromatic aldehydes and ketones are tolerated and successfully converted into the corresponding benzylboronates. By the same deoxygenation manifold with aliphatic aldehydes and ketones, we also enable a concise synthesis of 1,1,2-tris(boronates), a family of compounds that currently lack efficient synthetic methods. Given its simplicity and versatility, we expect that this novel borylation approach could show great promise in organoboron synthesis and inspire more carbonyl deoxygenative transformations in both academic and industrial settings.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Li, JB; Wang, HN; Qiu, ZH; Huang, CY; Li, CJ or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. In 2020 ORG BIOMOL CHEM published article about AEROBIC OXIDATION; SELECTIVE OXIDATION; ETHERS; COPPER; ISOCOUMARINS; PHTHALIDES; ALKANES in [Thatikonda, Thanusha; Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India; [Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2020, Cited 38. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A metal-free organocatalytic system has been developed for highly efficient benzylic C-H oxygenations of cyclic ethers using oxygen as an oxidant. This oxidation reaction utilizes alpha-angelica lactone as a low cost/low molecular weight catalyst. The optimized reaction conditions allow the synthesis of valued isocoumarins and phthalides from readily available precursors in good yields. Mechanistic studies indicate that the reaction pathway likely involves a radical process via a peroxide intermediate.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Thatikonda, T; Deepake, SK; Kumar, P; Das, U or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem