Category: benzofurans

An article The role of melanin in the grapevine trunk disease pathogen Lasiodiplodia gilanensis WOS:000607189100011 published article about LATENT PATHOGENS; FUNGAL MELANINS; BIOSYNTHESIS; BOTRYOSPHAERIACEAE; TRICYCLAZOLE; IDENTIFICATION; PENETRATION; GROWTH; MELANIZATION; APPRESSORIA in [Airam Rangel-Montoya, Edelweiss; Hernandez-Martinez, Rufina] Ctr Invest Cient & Educ Super Ensenada CICESE, Dept Microbiol, Ensenada 22860, Baja California, Mexico; [Paolinelli, Marcos] Inst Nacl Tecnol Agr INTA, Estn Expt Agr Mendoza, San Martin 3853, RA-5534 Mendoza, Argentina; [Paolinelli, Marcos] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina; [Rolshausen, Philippe] Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA in 2020, Cited 69. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

Lasiodiplodia (Botryosphaeriaceae) includes fungi that are considered among the most aggressive to grapevine, capable of causing cankers and necrotic lesions which eventually lead to death of host plants. A common characteristic of this genus is the presence of melanin in conidia and mycelium. Melanin is produced by the oxidation of phenolic and/or indolic compounds. For some fungi, this pigment is an essential factor for pathogenicity. This study characterized the types and the roles of melanin produced by Lasiodiplodia gilanensis. Using specific melanin inhibitors, L. gilanensis was shown to synthesize DOPA-melanin, DHN-melanin, and pyomelanin. DOPA-melanin was shown to be involved in production of aerial mycelium and protection against enzymatic lysis and oxidative stress; DHN-melanin to be involved in ramification of mycelium when exposed to nutrient deficiency; and pyomelanin to be related with hyphae development. The fungus used tyrosine as a precursor of DOPA-melanin and as carbon and nitrogen sources, and produced melanin inside the piths of infected plants. Genes involved in melanin synthesis were conserved among the Botryosphaeriaceae, highlighting the importance of melanin in this family.

Welcome to talk about 87-41-2, If you have any questions, you can contact Rangel-Montoya, EA; Paolinelli, M; Rolshausen, P; Hernandez-Martinez, R or send Email.. HPLC of Formula: C8H6O2

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Authors Butkevich, AN in AMER CHEMICAL SOC published article about FLUORESCENT-PROBES; CELL; FLUOROPHORE; MICROSCOPY in [Butkevich, Alexey N.] Max Planck Inst Med Res, Dept Opt Nanoscopy, D-69120 Heidelberg, Germany in 2021, Cited 41. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A modular synthetic approach toward diverse analogues of the far-red fluorophore silicon-rhodamine (SiR), based on a regioselective double nucleophilic addition of aryllanthanum reagents to esters, anhydrides, and lactones, is proposed. The reaction has improved functional group tolerance and represents a unified strategy toward cell-permeant, spontaneously blinking, and photoactivatable SiR fluorescent labels. In tandem with Pd-catalyzed hydroxy- or aminocarbonylation, it serves a streamlined synthetic pathway to a series of validated live-cell-compatible fluorescent dyes.

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Recommanded Product: Isobenzofuran-1(3H)-one. Hewage, ANDP; Yao, HL; Nammalwar, B; Gnanasekaran, KK; Lovell, S; Bunce, RA; Eshelman, K; Phaniraj, SM; Lee, MM; Peterson, BR; Battaile, KP; Reitz, AB; Rivero, M in [Hewage, Achala N. D. Punchi; Eshelman, Kate] Univ Kansas, Dept Chem, 2030 Becker Dr, Lawrence, KS 66047 USA; [Yao, Huili; Rivero, Mario] Louisiana State Univ, Dept Chem, 229A Choppin Hall, Baton Rouge, LA 70803 USA; [Nammalwar, Baskar; Gnanasekaran, Krishna Kumar; Bunce, Richard A.] Oklahoma State Univ, Dept Chem, Stillwater, OK 74078 USA; [Lovell, Scott] Univ Kansas, Prot Struct Lab, 2034 Becker Dr, Lawrence, KS 66047 USA; [Phaniraj, Sahishna M.; Lee, Molly M.; Peterson, Blake R.] Univ Kansas, Dept Med Chem, 2034 Becker Dr, Lawrence, KS 66047 USA; [Battaile, Kevin P.] Hauptman Woodward Med Res Inst, IMCA CAT, 9700 South Cass Ave,Bldg 435A, Argonne, IL 60439 USA; [Reitz, Allen B.] Fox Chase Chem Divers Ctr Inc, 3805 Old Easton Rd, Doylestown, PA 18902 USA; [Nammalwar, Baskar] 10522 Parkdale Ave, San Diego, CA 92126 USA; [Gnanasekaran, Krishna Kumar] 4591 Gatineau Ave, Mississauga, ON L4Z 2R9, Canada; [Eshelman, Kate] 10 Waterview Blvd, Parsippany, NJ 07054 USA; [Lee, Molly M.] NCI, Hatfield CRC, Bldg 10, Bethesda, MD 20892 USA published Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity in 2019, Cited 60. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small molecule inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- and 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively bind BfrB at the Bfd binding site. Challenging P. aeruginosa cells with the 4-substituted isoindoline analogs revealed a dose-dependent growth phenotype. Further investigation determined that the analogs elicit a pyoverdin hyperproduction phenotype that is consistent with blockade of the BfrB-Bfd interaction and ensuing irreversible accumulation of iron in BfrB, with concomitant depletion of iron in the cytosol. The irreversible accumulation of iron in BfrB prompted by the 4-substituted isoindoline analogs was confirmed by visualization of BfrB-iron in P. aeruginosa cell lysates separated on native PAGE gels and stained for iron with Ferene S. Challenging P. aeruginosa cultures with a combination of commercial fluoroquinolone and our isoindoline analogs results in significantly lower cell survival relative to treatment with either antibiotic or analog alone. Collectively, these findings furnish proof of concept for the usefulness of small molecule probes designed to dysregulate bacterial iron homeostasis by targeting a protein-protein interaction pivotal for iron storage in the bacterial cell.

Welcome to talk about 87-41-2, If you have any questions, you can contact Hewage, ANDP; Yao, HL; Nammalwar, B; Gnanasekaran, KK; Lovell, S; Bunce, RA; Eshelman, K; Phaniraj, SM; Lee, MM; Peterson, BR; Battaile, KP; Reitz, AB; Rivero, M or send Email.. Recommanded Product: Isobenzofuran-1(3H)-one

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Lukic, I; Carlin, S; Horvat, I; Vrhovsek, U in [Lukic, Igor; Horvat, Ivana] Inst Agr & Tourism, K Huguesa 8, Porec 52440, Croatia; [Lukic, Igor] Ctr Excellence Biodivers & Mol Plant Breeding, Svetosimunska 25, Zagreb 10000, Croatia; [Carlin, Silvia; Vrhovsek, Urska] Fdn Edmund Mach FEM, Res & Innovat Ctr, Dept Food Qual & Nutr, Via E Mach 1, I-38010 San Michele All Adige, TN, Italy; [Carlin, Silvia] Univ Udine, Dept Agr Food Environm & Anim Sci, Via Sci 208, I-33100 Udine, Italy published Combined targeted and untargeted profiling of volatile aroma compounds with comprehensive two-dimensional gas chromatography for differentiation of virgin olive oils according to variety and geographical origin in 2019, Cited 35. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC x GC-TOF-MS) was combined with conventional mono-dimensional GC-MS to differentiate Croatian virgin olive oils (VOO) according to variety and geographical origin, based on the profile of volatile aroma compounds isolated by HS-SPME. More than 1000 compounds were detected after untargeted profiling and 256 were identified or tentatively identified, providing one of the most detailed profiles of volatile aroma compounds in VOO up to date. Among them, 131 volatile compounds were significantly different across monovarietal VOOs, while 60 were found useful for the discrimination according to geographical origin. Many major lipoxygenase and minor non-lipoxygenase-generated compounds were shown to have discriminating ability with respect to both factors. Multivariate statistical analysis extracted twenty-one volatile markers with the highest discriminant power for varietal differentiation. The approach reported may have practical application in better understanding, defining, managing, and communicating the varietal or geographical typicity of monovarietal VOOs.

Welcome to talk about 87-41-2, If you have any questions, you can contact Lukic, I; Carlin, S; Horvat, I; Vrhovsek, U or send Email.. Formula: C8H6O2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities WOS:000497933800001 published article about ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SENKYUNOLIDE I; Z-LIGUSTILIDE; CHUANXIONG; INJURY; STROKE in [Fang, Xin; Ma, Qiang; Feng, Yi; Liang, Shuang] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China; [Zhang, Kai-Xia; Yao, Song-Yun; Jin, Yong-Sheng] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China in 2020, Cited 25. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

As part of our continuing efforts to discover structurally interesting bioactive phthalide derivatives, 23 of them with a structure incorporating thiophen or halogens were designed and synthesized, 17 of which are previously unreported. In vitro antiplatelet aggregation activity screening showed that 14b could significantly inhibit platelet aggregation induced by arachidonic acid, compared with edaravone (p < 0.01). Meanwhile, oxidative damage models using SH-SY5Y and PC12 cells induced by H2O2 were built to evaluate the antioxidant activity of the phthalide derivatives. In SH-SY5Y cells, compared with aspirin, 1a significantly increased the relative cell survival rate (p < 0.05). Compared with edaravone, 1a (p < 0.01) and 15b (p < 0.05) significantly increased the relative cell survival rate. In PC12 cells, 1a (p < 0.01), 15b (p < 0.01), and 12a (p < 0.05) remarkably increased the cell survival rate compared with edaravone. The present study identified lead structures to develop potential anti-ischemic stroke agents. Category: benzofurans. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

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I found the field of Pharmacology & Pharmacy very interesting. Saw the article SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF NOVEL DIBENZOTHIEPINES published in 2020. SDS of cas: 87-41-2, Reprint Addresses Pircalabioru, GG (corresponding author), Univ Bucharest, Res Inst, Bucharest 60101, Romania.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Considering the anti-infective potential of compounds containing the dibenzothiepine scaffold, we set out to obtain new compounds bearing this structure. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their microbiostatic/microbicidal and antibiofilm properties against reference and clinical microbial strains. The new compounds exhibited a broad spectrum of antimicrobial activity, which was more intensive for the S-oxidized compounds. Some of the compounds also inhibited the ability of the investigated strains to form biofilms on the inert substratum.

Welcome to talk about 87-41-2, If you have any questions, you can contact Stecoza, CE; Draghici, C; Caproiu, MT; Pircalabioru, GG; Marutescu, L or send Email.. SDS of cas: 87-41-2

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Tzirakis, MD; Malliaros, NG; Orfanopoulos, M in [Tzirakis, Manolis D.; Malliaros, Nikitas G.; Orfanopoulos, Michael] Univ Crete, Dept Chem, Voutes Campus, Iraklion 71003, Crete, Greece published Photochemical Reaction of o-Phthalaldehyde with Fullerene C-60: The Stimulus for the Phthalide Additions to C-60 in 2019, Cited 18. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A new, simple, and rapid photochemical reaction of o-phthalaldehyde with C-60 has been disclosed. This reaction afforded exclusively the unanticipated C-60-phthalide derivative 11 in good yield. The formation of this product is consistent with the intervention of a key free-radical intermediate -a benzylic radical- in the course of the reaction. The structure of 11 has been determined by the combined use of experimental and theoretical NMR studies. In the course of this study we further disclosed a new mode of radical reactivity of C-60 with a series of substituted phthalides (2, 15-17) catalyzed by tetrabutylammonium decatungstate.

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Recommanded Product: 87-41-2. Ovchinnikov, MY; Antipin, VA; Khursan, SL in [Ovchinnikov, Mikhail Yu; Antipin, Vyacheslav A.; Khursan, Sergey L.] Ufa Inst Chem UFRC RAS, 71 Prospect Oktyabrya, Ufa 450054, Russia published Thermostimulated luminescence of poly(diphenylenephthalide) films. Kinetics and mechanistic steps of irradiative processes in 2020, Cited 59. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Kinetics of thermostimulated luminescence (TSL) of poly(diphenylenephthalide) (PDPh) films has been studied using mathematical modelling and DFT approximation. TSL of PDPh-film was considered to be arising from irradiative deactivation of diphenylene (DP) fragment of polymer chain in excited state formed upon recombination of the spatial separated ion-radical pairs generated by photoexcitation. Two parallel monomolecular transformations leading to excited DP have been revealed: the first path is characterized by the activation parameters of the kinetic rate constant k1 which equal to Al ti 105 sec 1 and Eat ti 70 kJ mol(-1). This path may be interpreted in terms of mechanical relaxation theory by segmental polymer mobility as electron transfer (ET) from phthalide (Ph) anion-to DP cation-radical. The second channel is supposed to be consist of two consecutive ET from triarylmethyl anion-radical to phthalide neutral (A2 ti 1 sec 1, Ea2 ti 20 kJ mol(-1)), and then to DP cation-radical (A3 N 104 sec 1, E,3 N 40 kJ mol(-1)) of the polymer chain indicating y- and fl-relaxation, respectively. The revealed mechanistic steps and electron retention efficiency estimated in B97-2/6-311 + G(d,p) approximation for the most probable anion-radicals may point out the key role of domino quantum tunneling in transfer and recombination of charges in PDPh films.

Recommanded Product: 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

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An article alpha-Angelica lactone catalyzed oxidation of benzylic sp(3) C-H bonds of isochromans and phthalans WOS:000538169500011 published article about AEROBIC OXIDATION; SELECTIVE OXIDATION; ETHERS; COPPER; ISOCOUMARINS; PHTHALIDES; ALKANES in [Thatikonda, Thanusha; Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India; [Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2020, Cited 38. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A metal-free organocatalytic system has been developed for highly efficient benzylic C-H oxygenations of cyclic ethers using oxygen as an oxidant. This oxidation reaction utilizes alpha-angelica lactone as a low cost/low molecular weight catalyst. The optimized reaction conditions allow the synthesis of valued isocoumarins and phthalides from readily available precursors in good yields. Mechanistic studies indicate that the reaction pathway likely involves a radical process via a peroxide intermediate.

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Jiang, XL; Zhang, JH; Zhao, DM; Li, YH in [Jiang, Xiaolin; Zhao, Dongmei] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China; [Jiang, Xiaolin; Zhang, Jiahui; Li, Yuehui] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Suzhou Res Inst LICP, Lanzhou 730000, Peoples R China; [Zhang, Jiahui] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China published Aldehyde effect and ligand discovery in Ru-catalyzed dehydrogenative cross-coupling of alcohols to esters in 2019, Cited 25. HPLC of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The presence of different aldehydes is found to have a significant influence on the catalytic performance when using PN(H)P type ligands for dehydrogenation of alcohols. Accordingly, hybrid multi-dentate ligands were discovered based on an oxygen-transfer alkylation of PNP ligands by aldehydes. The relevant Ru-PNN(PO) system provided the desired unsymmetrical esters in good yields via acceptorless dehydrogenation of alcohols. Hydrogen bonding interactions between the phosphine oxide moieties and alcohol substrates likely assisted the observed high chemoselectivity.

Welcome to talk about 87-41-2, If you have any questions, you can contact Jiang, XL; Zhang, JH; Zhao, DM; Li, YH or send Email.. HPLC of Formula: C8H6O2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem