Category: benzofurans

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex published in 2020. Category: benzofurans, Reprint Addresses Otvos, SB; Kappe, CO (corresponding author), Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria.; Kappe, CO (corresponding author), RCPE, Ctr Continuous Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3 center dot DMS) was used to reduce various esters and amides under continuous-flow conditions. Taking advantage of the solvent-free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

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Category: benzofurans. Recently I am researching about PROTEIN-PROTEIN INTERACTIONS; BACTERIOFERRITIN STRUCTURE; IRON-METABOLISM; BINDING; ANTIBIOTICS; FERREDOXIN; RESISTANCE; DYNAMICS; PROMOTES; GALLIUM, Saw an article supported by the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [AI125529]; National Science FoundationNational Science Foundation (NSF) [MCB1615767]; Hauptman Woodward Medical Research Institute; U.S. Department of Energy, Office of Science, Office of Basic Energy SciencesUnited States Department of Energy (DOE) [DE-AC02-06CH11357]; National Institute of General Medical Sciences at the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [P30 GM110761]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [P30DK089507]; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI125529] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [P30DK089507] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [P30GM110761] Funding Source: NIH RePORTER. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Hewage, ANDP; Yao, HL; Nammalwar, B; Gnanasekaran, KK; Lovell, S; Bunce, RA; Eshelman, K; Phaniraj, SM; Lee, MM; Peterson, BR; Battaile, KP; Reitz, AB; Rivero, M. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small molecule inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- and 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively bind BfrB at the Bfd binding site. Challenging P. aeruginosa cells with the 4-substituted isoindoline analogs revealed a dose-dependent growth phenotype. Further investigation determined that the analogs elicit a pyoverdin hyperproduction phenotype that is consistent with blockade of the BfrB-Bfd interaction and ensuing irreversible accumulation of iron in BfrB, with concomitant depletion of iron in the cytosol. The irreversible accumulation of iron in BfrB prompted by the 4-substituted isoindoline analogs was confirmed by visualization of BfrB-iron in P. aeruginosa cell lysates separated on native PAGE gels and stained for iron with Ferene S. Challenging P. aeruginosa cultures with a combination of commercial fluoroquinolone and our isoindoline analogs results in significantly lower cell survival relative to treatment with either antibiotic or analog alone. Collectively, these findings furnish proof of concept for the usefulness of small molecule probes designed to dysregulate bacterial iron homeostasis by targeting a protein-protein interaction pivotal for iron storage in the bacterial cell.

Category: benzofurans. Welcome to talk about 87-41-2, If you have any questions, you can contact Hewage, ANDP; Yao, HL; Nammalwar, B; Gnanasekaran, KK; Lovell, S; Bunce, RA; Eshelman, K; Phaniraj, SM; Lee, MM; Peterson, BR; Battaile, KP; Reitz, AB; Rivero, M or send Email.

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Benzofuran – Wikipedia,
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An article Cercosporin-bioinspired selective photooxidation reactions under mild conditions WOS:000496489100021 published article about C-H BONDS; CATALYZED AEROBIC OXIDATION; ELECTRON-TRANSFER REACTIONS; LIGHT PHOTOREDOX CATALYSIS; VISIBLE-LIGHT; SINGLET OXYGEN; METAL-FREE; MOLECULAR-OXYGEN; PHOTOCATALYTIC OXIDATION; KIKUCHII MATSUMOTO in [Li, Jia; Bao, Wenhao; Tang, Zhaocheng; Guo, Baodang; Liu, Haili; Rao, Yijian] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China; [Zhang, Shiwei; Zhang, Yan] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R China; [Huang, Shuping] Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China in 2019, Cited 132. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

The development of an efficient system for selective oxidation of organic compounds to generate more valuable compounds with molecular oxygen is a significant challenge in industrial chemistry. Bioinspired by the ability of naturally occurring perylenequinonoid pigments (PQPs) to generate reactive oxygen species (ROS) upon photoirradiation, here we report that cercosporin, one of the perylenequinonoid pigments, can function as a cost-effective and environmentally friendly photocatalyst for a wide range of selective oxidations, including benzylic C-H bonds to carbonyls, amines to aldehydes, and sulfides to sulfoxides. All of the representative reactions proceeded smoothly with high efficiency under mild conditions. Owing to the use of inexpensive metal-free visible light-driven photocatalyst produced from microbial fermentation with cheap glucose as the starting material and the ease of handling, we expect that this developed method will be particularly attractive for many more applications in synthetic transformation.

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An article New phthalide derivatives from the Biscogniauxia sp. and their activities WOS:000484878400059 published article about SECONDARY METABOLITES; FUNGUS; SPIROBISNAPHTHALENES; PATHOGEN; SKELETON; LEAVES in [Liu, Yan-Ying; Xie, Jun; Zou, Jian; Hu, Dan; Chen, Guo-Dong; Yao, Xin-Sheng; Gao, Hao] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China; [Zhao, Huan] Jinan Univ, Coll Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China; [Guo, Liang-Dong] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100190, Peoples R China in 2019, Cited 23. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. COA of Formula: C8H6O2

Five new phthalide derivatives, biscogniphthalides A-D (1, 2, 3a/3b, and 4), were isolated from Biscogniauxia sp. (No. 69-8-7-1), along with one related known phthalide (5). Their structures were determined by comprehensive spectroscopic analyses, chemical derivatization, and quantum chemical ECD calculations. In addition, the anti-acetyl cholinesterase, antimicrobial, and anti-a-glucosidase activities of 1-5 were evaluated.

Welcome to talk about 87-41-2, If you have any questions, you can contact Liu, YY; Zhao, H; Xie, J; Zou, J; Hu, D; Guo, LD; Chen, GD; Yao, XS; Gao, H or send Email.. COA of Formula: C8H6O2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. Authors Shaalan, Y; Boulton, L; Jamieson, C in AMER CHEMICAL SOC published article about in [Shaalan, Youssef; Boulton, Lee] GlaxoSmithKline Med Res Ctr, Chem Dev, Stevenage SG1 2NY, Herts, England; [Shaalan, Youssef; Jamieson, Craig] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland in 2020, Cited 39. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (similar to 5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 ANGEW CHEM INT EDIT published article about CHANNEL ORGANIC SEMICONDUCTORS; PI-CONJUGATED MATERIALS; HIGH-PERFORMANCE; BUILDING-BLOCK; THIOPHENE-S,S-DIOXIDIZED INDOPHENINE; QUINOIDAL OLIGOTHIOPHENES; SIDE-CHAIN; MOLECULES; POLYMERS; ANALOGS in [Du, Tian; Gao, Ruiheng; Deng, Yunfeng; Wang, Cheng; Zhou, Qian; Geng, Yanhou] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China; [Deng, Yunfeng; Geng, Yanhou] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China; [Deng, Yunfeng; Geng, Yanhou] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China; [Geng, Yanhou] Tianjin Univ, Joint Sch Natl Univ Singapore & Tianjin Univ, Int Campus, Fuzhou 350207, Fujian, Peoples R China in 2020, Cited 46. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

A series of 1,3-indandione-terminated pi-conjugated quinoids were synthesized by alkoxide-mediated rearrangement reaction of the respective alkene precursors, followed by air oxidation. This new protocol allows access to quinoidal compounds with variable termini and cores. The resulting quinoids all show LUMO levels below -4.0 eV and molar extinction coefficients above 10(5) L mol(-1) cm(-1). The optoelectronic properties of these compounds can be regulated by tuning the central cores as well as the aryl termini ascribed to the delocalized frontier molecular orbitals over the entire molecular skeleton involving aryl termini. n-Channel organic thin-film transistors with electron mobility of up to 0.38 cm(2) V-1 s(-1) were fabricated, showing the potential of this new class of quinoids as organic semiconductors.

Welcome to talk about 87-41-2, If you have any questions, you can contact Du, T; Gao, RH; Deng, YF; Wang, C; Zhou, Q; Geng, YH or send Email.. Safety of Isobenzofuran-1(3H)-one

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Category: benzofurans. I found the field of Research & Experimental Medicine; Pharmacology & Pharmacy very interesting. Saw the article Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-kappa B expression published in 2019, Reprint Addresses Jiang, M; Bai, G (corresponding author), Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China.; Jiang, M; Bai, G (corresponding author), Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Atherosclerosis is initiated by the local inflammation response to lipid deposition, and the most commonly administered antiatherogenic drugs are statins. Based on traditional Chinese medicine (TCM) evidence, we aimed to find effective therapeutic agents other than statins. A TCM, Suxiao Jiuxin Pill (SX), has been widely used in curing cardiovascular diseases for thirty years. In this paper, a combination of pharmacologic studies and RNA-Seq transcriptomics were employed to explore the pharmacodynamic advantages of SX over atorvastatin in the ApoE(-/-) mouse. 113 differentially expressed genes that were modulated by SX to a greater degree than atorvastatin were primarily involved in immunomodulation. The expression of BTK, AKT1, c-jun and CD137 was effectively regulated by SX with better effect than atorvastatin. Then a dual-luciferase reporter assay for NF-kappa B inhibition was applied to identify active components in SX. As a result, Senkyunolide A (Sen A) and Ligustilide (Lig), the key immunomodulatory ingredients in SX, were found to inhibit the expression of CD137 which is a diagnostic biomarker in atherosclerosis. It was further confirmed that Lig effectively suppressed the expression of AP-1 and NF-kappa B and the phosphorylation of AKT. Therefore, Lig achieved its CD137 inhibition through suppressing the expression of AP-1 and AKT/NF-kappa B signaling pathway, which partly explains the immunomodulation of SX in atherosclerosis. Above all, phthalides may be the primary components of SX improving immune and inflammation response in atherosclerosis.

Category: benzofurans. Welcome to talk about 87-41-2, If you have any questions, you can contact Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G or send Email.

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Benzofuran – Wikipedia,
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I found the field of Engineering very interesting. Saw the article Partial oxidation of o-xylene to phthalic anhydride in a fixed bed reactor with axial thermowells published in 2020. Recommanded Product: 87-41-2, Reprint Addresses Dixon, AG (corresponding author), Worcester Polytech Inst, Dept Chem Engn, 100 Inst Rd, Worcester, MA 01609 USA.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The present study analyses the thermowell system for monitoring temperatures in a fixed bed catalytic reactor for the highly exothermic partial oxidation of o-xylene to phthalic anhydride. Particle-resolved computational fluid dynamics (CFD) simulations are presented for the cases of randomly-packed spheres inside cylindrical tubes with tube-to-particle diameter ratios (N) of 3.96, 5.96 and 7.99. Results are obtained for each N value for cases with inner thermowell radius to outer tube radius ratios of 0.0 (no thermowell), 0.05, 0.1 and 0.2. Comparisons of radial void fraction and axial velocity profiles, axial pressure drop and axial temperature profiles under reaction conditions are presented. The presence of the thermowell did change the mass and heat transfer and reaction inside and around the particles, especially at the bed center. The configurations of catalyst particles were rearranged, leading to changes in voidage, flow and temperature profile. The axial temperature profiles from the thermowells differed from the profiles in the undisturbed beds. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Recommanded Product: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Dixon, AG; Wu, Y or send Email.

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Benzofuran – Wikipedia,
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Application In Synthesis of Isobenzofuran-1(3H)-one. In 2020 DALTON T published article about SOLVENT-FREE HYDROBORATION; CYCLIC CARBONATES; TRANSFER HYDROGENATION; SELECTIVE REDUCTION; COMPLEXES SYNTHESES; METHANOL; CO2; DERIVATIVES; REACTIVITY; ALDEHYDES in [Cao, Xu; Wang, Weifan; Lu, Kai; Xue, Fei; Ma, Mengtao] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Peoples R China; [Yao, Weiwei] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China in 2020, Cited 55. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A low-valent magnesium(i) complex [((Xyl)Nacnac)Mg](2) was employed as a highly efficient precatalyst for the hydroboration of a variety of cyclic and linear organic carbonates, polycarbonates, CO2 and esters with HBpin under mild conditions. The resultant boronates can be used for the preparation of the corresponding value-added diols, triols or alcohols through hydrolysis.

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Cao, X; Wang, WF; Lu, K; Yao, WW; Xue, F; Ma, MT or send Email.

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An article Synthesis of Poly(Arylene Alkenylene)s by Pd-Catalyzed Three-Component Coupling Polycondensation of Diiodoarenes, Non-Conjugated Dienes, and Nucleophiles that Involves Chain Walking Isomerization WOS:000490302000001 published article about ALLYLIC AMINES; ARYL IODIDES; POLYMERIZATION; POLYMERS; COMPLEX; ETHYLENE; CYCLOPOLYMERIZATION; COPOLYMERIZATION; POLYETHYLENES; ALKYLENE)S in [Tan, Liyi; Takeuchi, Daisuke; Osakada, Kohtaro] Tokyo Inst Technol, Lab Chem & Life Sci, R1-03,4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan; [Takeuchi, Daisuke] Hirosaki Univ, Grad Sch Sci & Technol, Dept Frontier Mat Chem, 3 Bunkyo Cho, Hirosaki, Aomori 0368561, Japan in , Cited 41. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and carbonucleophiles afforded poly(arylene alkenylene)s with moderate molecular weight in good yield. The reaction involves Mizoroki-Heck coupling, olefin migration via chain walking, and addition of the carbonucleophile to the resulting pi-allylpalladium species. The polymerization with a slight excess of nucleophile with respect to diiodoarene also proceeded to give the polymer without significant decrease in molecular weight in spite of the nonstoichiometric mixture of the monomers. The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and diimide also proceeded. The base used in the reaction is critical for yield and molecular weight of the product. The reaction using NaHCO3 afforded the product with low solubility, which can be explained by the high molecular weight of the polymer and/or the strong interaction of the electron donating dimethoxyphenylene groups and electron accepting diimide groups in the polymer. (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Tan, LY; Takeuchi, D; Osakada, K or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem