Category: 497-23-4

Application of 497-23-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Jiang, Bolong, introduce new discover of the category.

Hydrodeoxygenation and hydrodesulfurization over Fe promoted Ni2P/SBA-15 catalyst

The Fe-doped Ni2P/Fe-SBA-15 was prepared by the temperature programmed reduction method at a relative low temperature of 673 K. The effect of Fe on the catalytic performance for benzofuran (BF) hydrodeoxygenation (HDO) and dibenzothiophene (DBT) hydrodesulfurization (HDS) were investigated. The catalysts were characterized by means of X-ray diffraction (XRD), N-2 adsorption-desorption, inductively coupled plasma mass spectrometry (ICP-MS), X-ray photoelectron spectroscopy (XPS), temperature-programmed desorption of ammonia (NH3-TPD), and transmission electron microscope (TEM) and CO uptakes. The results indicate the incorporation of Fe into SBA-15 contributes to the exposure of smaller Ni2P particles (5.6 nm) with an uniform dispersion, along with enhancement of weak and medium acid strengths. Compared with Ni2P/SBA-15, the Fe-doped Ni2P/Fe-SBA-15 exhibited a much higher BF conversion of 91.7% with an improved total deoxygenated product yield of 83.3%. The excellent HDO performance of Ni2P/Fe-SBA-15 can be ascribed to the exposure of highly-dispersed smaller Ni2P particles. Meanwhile, the improved dehydration of 2-EtPh to EB and the high deoxygenated product selectivity can be attributed to the enhanced acidity. As compared to the Ni2P/SBA-15, the Fe-doped Ni2P/Fe-SBA-15 showed a higher DBT HDS activity of 96.3% with the BP formation at a great proportion of 90.3%, indicating that DBT was mainly transformed through the desulfurization pathway during HDS. (C) 2019 Elsevier B.V. All rights reserved.

Application of 497-23-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 497-23-4 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2, belongs to benzofurans compound. In a document, author is Mertens, M. A. Stephanie, introduce the new discover, Safety of Furan-2(5H)-one.

One-Pot Two-Step Chemoenzymatic Cascade for the Synthesis of a Bis-benzofuran Derivative

Chemoenzymatic cascades enable reactions with the high productivity of chemocatalysts and high selectivity of enzymes. Nevertheless, the combination of these different fields of catalysis is prone to mutual deactivation of metal- and biocatalysts. In this study, a one-pot sequential two-step catalytic cascade reaction was successfully implemented for the synthesis of a methylene-bridged bis(2-substituted benzofuran). In the first step, a palladium-free Sonogashira reaction is used for the synthesis of a benzofuran derivative. In the subsequent step, the formed 2-substituted benzofuran is hydroxylated by the monooxygenase P450 BM3 variant (A74S-F87V-L188Q) and undergoes further elimination reactions. The study proofs that combination of Cu scorpionate catalyzed Sonogashira cross-coupling and P450 mediated oxidation is possible and results in up to 84 % yield of the final product. The oxidation reaction is boosted by capturing inhibiting reaction components.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 497-23-4. Safety of Furan-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 497-23-4, Name is Furan-2(5H)-one, formurla is C4H4O2. In a document, author is Sun, Rui, introducing its new discovery. Recommanded Product: 497-23-4.

High-efficiency all-small-molecule organic solar cells based on an organic molecule donor with an asymmetric thieno[2,3-f] benzofuran unit

Two p-type small molecules BDTT-TR and TBFT-TR with benzo[1,2-b ‘:4,5-b ‘]dithiophene (BDT) and thieno[2,3-f]benzofuran (TBF) as central core units are synthesized and used as donors in all-small-molecule organic solar cells (all-SMOSCs) with a narrow-bandgap small molecule Y6 (2,2 ‘-((2Z,2 ‘ Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo [3,4-e]thieno[2 ”,3”:4’,5 ‘]thieno[2 ‘,3 ‘: 4,5]pyrrolo[3,2-g]thieno[2 ‘,3 ‘:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene))bis (5,6- difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile) as the acceptor. In comparison to BDTT-TR with centrosymmetric BDT as the central unit, TBFT-TR with asymmetric TBF as the central unit shows red-shifted absorption, higher charge-carrier mobility and better charge pathway in blend films. The power conversion efficiency (PCE) of the all-SMOSCs based on TBFT-TR:Y6 reaches 14.03% with a higher short-circuit current density of 24.59 mA cm(-2) and a higher fill factor of 72.78% compared to the BDTT-TR:Y6 system. The PCE of 14.03% is among the top efficiencies of all-SMOSCs reported in the literature to date.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 497-23-4 help many people in the next few years. Recommanded Product: 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Takabatake, Tetsuhiko,once mentioned of 497-23-4, Name: Furan-2(5H)-one.

Discovery of orthogonal synthesis using artificial intelligence: Pd(OAc)(2)-catalyzed one-pot synthesis of benzofuran and bicyclo[3.3.1] nonane scaffolds

A synthetic route for the common intermediate, methyl 2-formylbenzofuran-7-carboxylate (7a), to efficiently assemble three bioactive benzofurans 4-6 was explored using the artificial intelligence system SYNSUP. Among the routes proposed by SYNSUP, we investigated a three-step synthesis of 7a using methyl 4-ally-3-oxohept-6-enoate (10). A new catalytic reaction was found in which 7a was directly obtained from 10 in a single step with a yield of 24%. It was found that this chemical yield could be increased to 74% when methyl 3-allyl-2-hydroxybenzoate (9a), an intermediate of the above one-pot transformation, was subjected to the catalytic process. In addition, in this catalytic process, 8a (76%) and 11 (77%) were each selectively synthesized from 10 by changing only the solvent. Therefore, we created a novel orthogonal synthesis of methyl 2-methylbenzofuran-7-carboxylate (8a) and methyl 9-oxobicyclo[3.3.1]nona-3,6-diene-1-carboxylate (11). Finally, the total syntheses of bioactive benzofurans 4-6 were completed smoothly using 7a and 8a. (C) 2020 Elsevier Ltd. All rights reserved.

Interested yet? Keep reading other articles of 497-23-4, you can contact me at any time and look forward to more communication. Name: Furan-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a document, author is Xu, Hang, introduce the new discover, HPLC of Formula: C4H4O2.

Design, Synthesis and Antifungal Activity of Benzofuran and Its Analogues

The Summary of main observation and conclusion Benzofuran has antifungal activity as the inhibitor of N-myristoyltransferase. Twenty-nine novel benzofuran-semicarbazide hybrids were designed and synthesized by principle of drug combinationatory. On this basis, the benzofuran ring was simplified to a resorcinol structure, and sixteen novel 1,3-dialkoxybenzene-semicarbazide hybrids were designed and synthesized. All structures of the target compounds were characterized by HRMS and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against eight strains of pathogenic fungi with fluconazole as positive control. According to the results of the target compounds, structure-activity relationship (SAR) is summarized. The inhibitory activity against the tested strains of simplified compounds (K01-K16) has different levels improvement compared with compounds Z01-Z29. K01-K16 showed significant antifungal activities against A. fumigatus, C. kruseii, and sensitive C. albicans 5314. Notably, compounds Z20, Z22, K10, K11 and K16 also displayed different activities against two fluconazole-resistance strains that were isolated from AIDS patients. The minimal inhibitory concentration (MIC) values against fluconazole-resistant strains were in the range of 2-8 mu g/mL and 4-32 mu g/mL, respectively. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 497-23-4 is helpful to your research. HPLC of Formula: C4H4O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 497-23-4, Name is Furan-2(5H)-one, molecular formula is , belongs to benzofurans compound. In a document, author is Bergkemper, Melanie, Name: Furan-2(5H)-one.

Synthesis of sigma Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

With the aim to develop new sigma(2) receptor ligands, spirocyclic piperidines or cyclohexanamines with 2-benzopyran and 2-benzofuran scaffolds were connected to the 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety by variable linkers. In addition to flexible alkyl chains, linkers containing an amide as functional group were synthesized. The 2-benzopyran and 2-benzofuran scaffold of the spirocyclic compounds were synthesized from 2-bromobenzaldehyde. The amide linkers were constructed by acylation of amines with chloroacetyl chloride and subsequent nucleophilic substitution, the alkyl linkers were obtained by LiAlH4 reduction of the corresponding amides. For the development of sigma(2) receptor ligands, the spirocyclic 2-benzopyran scaffold is more favorable than the ring-contracted 2-benzofuran system. Compounds bearing an alkyl chain as linker generally show higher sigma affinity than acyl linkers containing an amide as functional group. A higher sigma(1) affinity for the cis-configured cyclohexanamines than for the trans-configured derivatives was found. The highest sigma(2) affinity was observed for cis-configured spiro[[2]benzopyran-1,1 ‘-cyclohexan]-4 ‘-amine connected to the tetrahydroisoquinoline system by an ethylene spacer (cis-31, K-i (sigma(2))=200 nM; the highest sigma(1) affinity was recorded for the corresponding 2-benzofuran derivative with a CH2C=O linker (cis-29, K-i (sigma(1))=129 nM).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 497-23-4, in my other articles. Name: Furan-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: Furan-2(5H)-one, 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2, belongs to benzofurans compound. In a document, author is Jiang, Bolong, introduce the new discover.

Synthesis of Ni2P/Al2O3 utilizing triphenylphosphine (TPP) as the phosphorus source for hydrodeoxygenation of benzofuran

A novel route to synthesize highly active Ni2P/Al2O3 (TPP) utilizing triphenylphosphine (TPP) as the phosphorus source at a low temperature of 573 K is described. The as-prepared catalysts were characterized by X-ray diffraction (XRD), CO uptake, Brunner-Emmett-Teller (BET) measurements, and X-ray photoelectron spectroscopy (XPS). The catalytic activity of the Ni2P/Al2O3 (TPP) catalyst and the role of the TPP phosphorus source were studied using hydrodeoxygenation (HDO) of benzofuran (BF) as a probe reaction. The results show that the use of TPP as the phosphorus source could suppress the strong interaction between phosphate and Al2O3, thereby the formation of AlPO4 was avoided. As compared to the Ni2P/Al2O3 prepared by using (NH4)(2)HPO4 as the phosphorus source, Ni2P/Al2O3 (TPP) possessed significantly higher surface area and smaller Ni2P particle size. The HDO activity and yield of O-free products over the Ni2P/Al2O3 (TPP) catalyst were increased by 17.2% and 36.0%, respectively, when compared with those found for Ni2P/Al2O3 prepared using (NH4)(2)HPO4. The use of TPP as the phosphorus source could effectively promote the dehydration of 2-ethylphenol (2-EtPh) to form ethylbenzene (EB), and the demethylation of ethylcyclohexane (ECH) to methylcyclohexane (MCH).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 497-23-4. Recommanded Product: Furan-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Gao, Feng,once mentioned of 497-23-4, Application In Synthesis of Furan-2(5H)-one.

Benzofuran-isatin hybrids tethered via different length alkyl linkers and their in vitro anti-mycobacterial activities

A series of novel benzofuran-isatin hybrids 6a-m tethered through different length alkyl linkers propylene, butylene, pentylene and hexylene were designed, synthesized and evaluated for their in vitro anti-mycobacterial activities against both drug-susceptible and multi-drug resistant (MDR) Mycobacterium tuberculosis (MTB) and cytotoxicity towards VERO cells. All hybrids with acceptable cytotoxicity in VERO cells (CC50:64 to>1024 mu g/mL) also exhibited considerable anti-mycobacterial activities against both drug-susceptible and MDR-MTB strains with MIC in a range of 0.125-4 mu g/mL. The SAR indicated that the length of the linker played a pivotal role on the activity, and the longer linker could enhance the activity. The most active hybrid 6d (MIC:0.125 and 0.125 mu g/mL) was comparable to or better than rifampicin (MIC:0.5 mu g/mL) and isoniazid (MIC:0.06 mu g/mL) against MTB H(37)Rv, and was >256 folds more potent than rifampicin (MIC:64 mu g/mL) and isoniazid (MIC:>128 mu g/mL) against MDR-MTB strain, but was less active than TAM16 (MIC:<0.06 mu g/mL against the tested two strains). The hybrid 6d also showed low cytotoxicity towards VERO cell (CC50:128 mu g/mL), but it was inferior to TAM16 in metabolic stability and in vivo pharmacokinetic profiles. Interested yet? Keep reading other articles of 497-23-4, you can contact me at any time and look forward to more communication. Application In Synthesis of Furan-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 497-23-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Ibrahim, Magdy A., introduce new discover of the category.

Chemical behavior of 4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromene-6-carboxaldehyde towards carbon nucleophilic reagents

The chemical behavior of 6-formylkhellin (1) was investigated toward a variety of carbon nucleophiles. Treatment of aldehyde 1 with cyanoacetamide, N-benzylcyanoacetamide produced pyridine-3-carboxamides 3 and 4. Treatment of carboxaldehyde 1 with malononitrile dimer and 1H-benzimidazol-2-ylacetonitrile gave 1,6-naphthyridine 5 and pyrido[1,2-a]benzimidazole 6, respectively. Some novel pyrazolo[3,4-b]pyridine 7, pyrido[2,3-d]pyrimidines 8 and 9 were synthesized from the ring opening ring closure reactions of carboxaldehyde 1 with certain heterocyclic enamines. In addition, reaction of carboxaldehyde 1 with certain cyclic enols produced a variety of products. Treatment of carboxaldehyde 1 with 1,3-cyclohexanediones gave xanthene-1,8-diones 19 and 20. Reaction of carboxaldehyde 1 with 5-methyl-2,4-dihydro-3H-pyrazol-3-one proceeds in 1:2 M ratio producing pyrazolo [4 ‘,3 ‘:5,6]pyrano[2,3-c]pyrazole derivative 22. Carboxaldehyde 1 reacted with certain heterocyclic compounds containing active methylene groups to give the corresponding condensation products 22-27. The synthesized compounds were screened in vitro for their antimicrobial activity and showed high to moderate activities against the tested microorganisms.

Related Products of 497-23-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 497-23-4 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Sivamuthuraman, Koilpitchai,once mentioned of 497-23-4, Category: benzofurans.

Catalytic enantioselective Michael addition of 2-substituted benzofuran-3-ones to 2-enoyl pyridines

An organocatalytic diastereo- and enantioselective synthesis of 2,2 ‘-disubstituted benzofuran-3-ones bearing adjacent quaternary and tertiary stereocenters has been achieved through Michael addition of 2-substituted benzofuran-3-ones to 2-enoyl pyridines. Both the enantiomeric forms of the major diastereomer were obtained using l-proline derived squaramide and quinine derived bis squaramide with excellent yield (up to 98%) and stereoselectivities (up to 97 : 3 dr and 98% ee). The control experiment revealed that the presence and position of nitrogen atoms in the 2-enoylpyridine have played a crucial role in the stereochemical outcome of the product.

Interested yet? Keep reading other articles of 497-23-4, you can contact me at any time and look forward to more communication. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem