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Reference of 496-41-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article,once mentioned of 496-41-3

Dianions (2), (5), and (10), can be derived from the corresponding benzofurancarboxylic acids using lithium diisopropylamide, and are useful intermediates for the homologation of the parent acids.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1751O – PubChem

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A new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2- carboxamides (3a-3d and 4a’-4c’) were synthesized. Compounds (3a, 3b, and 4a’-4c’) were tested in vivo using Triton-WR-1339-induced hyperlipidemic rats as an experimental model for their hypolipidemic activity. The tested animals were divided into eight groups: control, hyperlipidemic, 3a, 3b, 4a’, 4b’, 4c’, and bezafibrate. At a dose of 15 mg/kg, the elevated plasma triglyceride (TG) levels were significantly reduced in compounds 3b (p <0.0001) and 4c' (p <0.05) after 12 and 24 h compared to the normal control group. Furthermore, high-density lipoprotein-cholesterol levels were remarkably increased in compounds 3b (p <0.001) and 4c' (p <0.05). Meanwhile, compound 4b' slightly reduced the TG levels after 12 and 24 h. The present study demonstrated new properties of the novel series of benzofuran-2-carboxamides 3b and 4c' as potent lipid-lowering agents. It is, therefore, reasonable to assume that compounds 3b and 4c' may have a promising potential in the treatment of hyperlipidemia and coronary heart diseases. A new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides (3a-3d and 4a'-4c') were synthesized and most of them were tested in vivo for their hypolipidemic activity. Compounds 3b and 4c' turned out to be potent lipid-lowering agents and thus may have a promising potential in the treatment of hyperlipidemia and coronary heart diseases. Copyright Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. category: benzofuran, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 496-41-3, in my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1722O – PubChem

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An iron-catalyzed hydrofluorination of unactivated alkenes has been developed. The use of a multidentate ligand and the fluorination reagent N-fluorobenzenesulfonimide (NFSI) proved to be critical for this reaction, which afforded various fluorinated compounds in up to 94 % yield.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2030O – PubChem

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Application of 496-41-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Patent,once mentioned of 496-41-3

Platelet Activating Factor (PAF) antagonists which comprise the compounds of the formula (I): STR1 wherein A is an optionally substituted phenyl or an optionally substituted heterocyclic group; X is methylene group, carbonyl group or thiocarbonyl group; R1, R2 and R3 are independently a lower alkyl group, and their salts are excellent in absorption from the intestinal canal. Among the compounds of the formula (I), those wherein A is an optionally substituted 2,3-dihydro-1-benzoxepin-4-yl group are novel compounds and exhibit excellent PAF antagonism.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1699O – PubChem

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496-41-3, Name is Benzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. Application In Synthesis of Benzofuran-2-carboxylic acidIn an article, once mentioned the new application about 496-41-3.

Benzo- and naphthofuran carboxylates 1, 2 and carboxamides 3, 4 were synthesized and pyrolysed by flash vacuum pyrolysis at 550 and 650 C/10?2 mmHg. 2-Formylbenzonitrile 7 from benzofurans and 2-formylnaphthonitrile 14 from naphthofurans were isolated and identified as major products. The mechanism suggested for these pyrolytic reactions involves elimination of alcohol and amine from carboxylates 1, 2 and carboxamides 3, 4 respectively, followed by extrusion of CO to form phenoxy and naphthoxycarbenes that leads to 7 and 14 respectively.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1829O – PubChem

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Benzofuran derivatives and benzofuransare presented as scaffolds in complex molecules and have attracted much attention and prevalent interest due to their interesting biological activity. They also exist in several numbers of naturally occurring compounds and exhibiting biological activity. In this review, we will try to underscore the reactivity of benzofurans through comprehension and giving a full perspective to the readers.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1814O – PubChem

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Benzofuran derivatives and benzofuransare presented as scaffolds in complex molecules and have attracted much attention and prevalent interest due to their interesting biological activity. They also exist in several numbers of naturally occurring compounds and exhibiting biological activity. In this review, we will try to underscore the reactivity of benzofurans through comprehension and giving a full perspective to the readers.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1813O – PubChem

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The invention relates to benzofuranylimidazole derivatives of the general formula (1) STR1 wherein R 1 and R 2 represent various radicals, to a process for their preparation and to pharmaceutical compositions containing them.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1691O – PubChem

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Reference of 496-41-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article,once mentioned of 496-41-3

The synthesis of novel 3-aryl-2-arylamidobenzofurans has been accomplished via a Curtius rearrangement strategy in four steps from benzofuran-2-carboxylic acids. The requisite Suzuki-Miyaura cross-coupling, with benzyl 3-bromobenzofuran-2-ylcarbamate or 2-arylamido-3-bromobenzofurans, revealed an unusual reductive debromination process due to the presence of the free NH group. This dehalogenation can be suppressed by N-alkylation. DMAP is an efficient reagent for the one-pot conversion of benzyl benzofuran-2-ylcarbamates into the corresponding benzofuran-2-arylamides through aroylation, thus acting both as an acyl transfer reagent and a deprotecting agent of the Cbz group. A mechanism is postulated.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1755O – PubChem

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A calcium-catalyzed, dehydrative, ring-opening cyclization of (hetero)aryl cyclopropyl carbinols is reported. The cyclopropyl carbinols are prepared directly from the corresponding donor-acceptor (D-A) cyclopropanes. The calcium catalyst catalyzes the formation of putative (hetero)aryl cyclopropyl carbinyl cations that undergo ring-opening to allylcarbinyl cations. Subsequent intramolecular Friedel-Crafts reaction affords (hetero)aryl-fused cyclohexa-1,3-dienes in up to 97% yield. This approach represents the first example of catalysis for this intramolecular, dehydrative ring-opening cyclization and outperforms the previous reports using stoichiometric Lewis acids.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1951O – PubChem