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This invention relates in general to certain substituted 3,7-dioxoazepan-4-ylamides of Formula (1) which are protease inhibitors.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1661O – PubChem

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 496-41-3 is helpful to your research. Synthetic Route of 496-41-3

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This invention relates to a method of preparation of benzofuran-2-carboxylic acid {(S)-3-methyl-1-[(4S,7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1710O – PubChem

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Liquid phase parallel synthesis has been developed to synthesize a novel series of iminodiacetic acid derivatives targeting the integrin receptors. This library was synthesized using a four-step reaction sequence. In each step of the sequence, the PEG-bound products were precipitated selectively and the excess reagents and the by-products were removed by simple filtration. The most notable result was that the library members were obtained in high purities (>90% pure).

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1767O – PubChem

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Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 496-41-3. In my other articles, you can also check out more blogs about 496-41-3

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Efficient construction of 2-sulfonylbenzo[b]furans is achieved from readily available trans-2-hydroxycinnamic acids and sodium sulfinates mediated by the CuCl2.2H2O/AgTFA system under mild conditions. This unprecedented synthetic protocol provides expedient access to a series of products in one step via a protodecarboxylation/C-S bond formation/C-O bond formation cascade.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1875O – PubChem

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Tetrakis(dimethylamido)diboron and tetrahydroxydiboron are herein reported as new catalysts for the synthesis of aryl amides by catalytic condensation of aromatic carboxylic acids with amines. The developed protocol is both simple and highly efficient over a broad range of substrates. This method thus represents an attractive approach for the use of diboron catalysts in the synthesis of amides without having to resort to stoichiometric or additional dehydrating agents.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1953O – PubChem

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N6-(Heteroarylcarbonyl)adenines were synthesized as candidate BRD4 inhibitors, and their structure-activity relationships were investigated. Among the synthesized compounds, N6-[(3-methoxythiophen-2-yl)carbonyl]adenine (15) showed the most potent BRD4-inhibitory activity.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1725O – PubChem

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The present invention provides compounds of the formula (I) wherein R1 and R2 and B are as herein described, pharmaceutical compositions comprising these compounds, use of these compounds for the preparation of pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of disorders and diseases wherein modulation of the H3 receptor is beneficial.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1625O – PubChem

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496-41-3, Name is Benzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. category: benzofuranIn an article, once mentioned the new application about 496-41-3.

3-Oxooxa- and 3-oxoazacycloalk-4-enes were obtained with good yield from 1-(omega-alkenyloxy)- and 1-(omega-alkenylamino)-but-3-en-2-ones by using a ring-closing metathesis. This methodology has been used to synthesize an inhibitor of cathepsin K.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1985O – PubChem

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Synthetic Route of 496-41-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a article,once mentioned of 496-41-3

Aggrecanases are recently discovered enzymes that cleave aggrecan, a key component of cartilage. Aggrecanase inhibitors may provide a unique means to halt the progression of cartilage destruction in osteoarthritis. The synthesis and evaluation of biphenylsulfonamidocarboxylic acid inhibitors of aggrecanase-1 are reported. Compound 24 demonstrated 89% inhibition of proteoglycan degradation at 10 mug/mL and has an oral bioavailability in rat of 35%.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2028O – PubChem

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The development of a palladium-catalyzed decarboxylative coupling reaction of arene carboxylates with olefinic substrates is described. The optimized procedure for decarboxylative palladation employs Pd(O2CCF3)2 as catalyst (0.2 equiv) in the presence of Ag2CO3 (3 equiv) in the solvent 5% DMSO-DMF and proceeds at temperatures of 80-120 C with a wide range of arene carboxylates and alkenes as substrates. The process is proposed to proceed by an initial Ar-SE reaction involving ipso attack of an electrophilic Pd(II) intermediate on an arene carboxylate to form an arylpalladium(II) species with loss of carbon dioxide. This intermediate is then proposed to react with an olefinic substrate by steps common to the Heck coupling process. Reoxidation of the liberated Pd(0) in situ is proposed to establish the catalytic cycle. Copyright

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1911O – PubChem