Category: 496-41-3

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C9H6O3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 496-41-3

Because of the large degree of homology among dopamine D2-like receptors, discovering ligands capable of discriminating between the D2, D3, and D4 receptor subtypes remains a significant challenge. Previous work has exemplified the use of bitopic ligands as a powerful strategy in achieving subtype selectivity for agonists and antagonists alike. Inspired by the potential for chemical modification of the D3 preferential agonists (+)-PD128,907 (1) and PF592,379 (2), we synthesized bitopic structures to further improve their D3R selectivity. We found that the (2S,5S) conformation of scaffold 2 resulted in a privileged architecture with increased affinity and selectivity for the D3R. In addition, a cyclopropyl moiety incorporated into the linker and full resolution of the chiral centers resulted in lead compound 53 and eutomer 53a that demonstrate significantly higher D3R binding selectivities than the reference compounds. Moreover, the favorable metabolic stability in rat liver microsomes supports future studies in in vivo models of dopamine system dysregulation.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1735O – PubChem

496-41-3, Name is Benzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. SDS of cas: 496-41-3In an article, once mentioned the new application about 496-41-3.

There are a variety of lipoxygenases in the human body (hLO), each having a distinct role in cellular biology. Human reticulocyte 15-lipoxygenase-1 (15-hLO-1), which catalyzes the dioxygenation of 1,4-cis,cis-pentadiene- containing polyunsaturated fatty acids, is implicated in a number of diseases including cancer, atherosclerosis, and neurodegenerative conditions. Despite the potential therapeutic relevance of this target, few inhibitors have been reported that are both potent and selective. To this end, we have employed a quantitative high-throughput (qHTS) screen against ?74000 small molecules in search of reticulocyte 15-hLO-1 selective inhibitors. This screen led to the discovery of a novel chemotype for 15-hLO-1 inhibition, which displays nM potency and is >7500-fold selective against the related isozymes, 5-hLO, platelet 12-hLO, epithelial 15-hLO-2, ovine cyclooxygenase-1, and human cyclooxygenase-2. In addition, kinetic experiments were performed which indicate that this class of inhibitor is tight binding, reversible, and appears not to reduce the active-site ferric ion.

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Benzofuran – Wikipedia,
Benzofuran | C8H1938O – PubChem

Related Products of 496-41-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a article，once mentioned of 496-41-3

A Cu(OAc)2-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group. A wide range of sulfonamides, amides, and anilines function as amine donors in this reaction. Heterocycles present in both reactants are tolerated, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzoates.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 496-41-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1959O – PubChem

Electric Literature of 496-41-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a article，once mentioned of 496-41-3

The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget’s disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 496-41-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1688O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of Benzofuran-2-carboxylic acid, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 496-41-3, name is Benzofuran-2-carboxylic acid. In an article，Which mentioned a new discovery about 496-41-3

Thirty-nine caudatin analogs were designed and synthesized. Their anti-hepatitis B virus (HBV) activities were evaluated in vitro. Among them, twenty-three compounds showed much better anti-HBV activity than caudatin, and eleven compounds significantly inhibited the HBV DNA replication with IC50 values < 10 muM. Interestingly, three compounds (22, 28, 29) exhibited excellent activity against the secretion of HBsAg (IC50 = 63.02 muM, 52.81 muM, 56.08 muM), HBeAg (IC50 = 204.80 muM, 173.51 muM, 70.39 muM), along with HBV DNA replication (IC50 = 24.55 muM, 5.69 muM, 8.23 muM) with lower cytotoxicity. The structure-activity relationships (SARs) of these caudatin analogs were also discussed. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 496-41-3, help many people in the next few years.Quality Control of Benzofuran-2-carboxylic acid

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Benzofuran – Wikipedia,
Benzofuran | C8H2011O – PubChem

Reference of 496-41-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Patent，once mentioned of 496-41-3

The invention discloses a small molecule heterodimer for tumor treatment and application thereof. The micromolecular heterocyclic dimer has the following structure. Experiments prove that the small-molecule heterocyclic dimer is wide in tumor inhibition spectrum and strong in anti-tumor activity, and human cervical cancer cells HeLa, human liver cancer cells Hep G2, human breast cancer cells FaDu and human non-small cell A549 lung cancer cells are IC. A valve 50 IC of human breast adenocarcinoma cell MCF 10A far higher than control drug ligustrazine reaching a muM levelA valve 50 Above tumor cells, high efficiency and low toxicity characteristics are reflected. The small molecule heterodimer has potential application value in the aspect of antitumor drug development. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1670O – PubChem

Electric Literature of 496-41-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article，once mentioned of 496-41-3

The direct oxidative coupling of 2-amino- and 2-hydroxybenzoic acids with internal alkynes proceeds efficiently in the presence of a rhodium/copper catalyst system under air to afford the corresponding 8-substituted isocoumarin derivatives, some of which exhibit solid-state fluorescence. Depending on conditions, 4-ethenyl-carbazoles can be synthesized selectively from 2-(arylamino)benzoic acids. The oxidative coupling reactions of heteroarene carboxylic acids as well as aromatic diacids with an alkyne are also described.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1965O – PubChem

Related Products of 496-41-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 496-41-3, Name is Benzofuran-2-carboxylic acid,introducing its new discovery.

Reductive electrosynthesis has faced long-standing challenges in applications to complex organic substrates at scale. Here, we show how decades of research in lithium-ion battery materials, electrolytes, and additives can serve as an inspiration for achieving practically scalable reductive electrosynthetic conditions for the Birch reduction. Specifically, we demonstrate that using a sacrificial anode material (magnesium or aluminum), combined with a cheap, nontoxic, and water-soluble proton source (dimethylurea), and an overcharge protectant inspired by battery technology [tris(pyrrolidino)phosphoramide] can allow for multigram-scale synthesis of pharmaceutically relevant building blocks. We show how these conditions have a very high level of functional-group tolerance relative to classical electrochemical and chemical dissolving-metal reductions. Finally, we demonstrate that the same electrochemical conditions can be applied to other dissolving metal-type reductive transformations, including McMurry couplings, reductive ketone deoxygenations, and epoxide openings.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1926O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 496-41-3, name is Benzofuran-2-carboxylic acid, introducing its new discovery. Recommanded Product: Benzofuran-2-carboxylic acid

A new series of benzothiazole amide and urea derivatives tethered with the privileged pyridylamide moiety by ether linkage at the 6-position of benzothiazole (22 final compounds) has been designed and synthesized as potent anticancer sorafenib analogs. A selected group of twelve derivatives was appraised for its antiproliferative activity over a panel of 60 human cancer cell lines at a single dose concentration of 10 1/4M at National Cancer Institute (NCI, USA). Compounds 4b, 5a, 5b and 5d exhibited promising growth inhibitions and thus were further tested in advanced 5-dose testing assay to determine their GI50 values. The cellular based assay results revealed that 3,5-bis-trifluoromethylphenyl (5b) urea member is the best derivative with superior potency and efficacy compared to sorafenib as well as notable extended spectrum activity covering 57 human cancer cell lines. Kinase screening of compound 5b showed its kinase inhibitory effect against both B-RafV600E and C-Raf. Moreover, the most potent derivatives in cells were investigated for their RAF inhibitory activities, and the results were rationalized with the molecular docking study. Profiling of CYP450 and hERG channel inhibitory effects for the active compounds revealed their low possibilities to exhibit undesirable drug-drug interactions and cardiac side effects.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 496-41-3, and how the biochemistry of the body works.Recommanded Product: Benzofuran-2-carboxylic acid

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1791O – PubChem

Application of 496-41-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article，once mentioned of 496-41-3

With the aim of developing novel scaffolds as anticancer agents and inhibitors of NF-kappaB activity, 60 novel benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives (1a-s, 2a-k, 3a-s, and 4a-k) were designed and synthesized from the reference lead compound KL-1156, which is an inhibitor of NF-kappaB translocation to the nucleus in LPS-stimulated RAW 264.7 macrophage cells. The novel benzofuran- and 2,3-dihydrobenzofuran-2-carboxamide derivatives exhibited potent cytotoxic activities (measured by the sulforhodamine B assay) at low micromolar concentrations against six human cancer cell lines: ACHN (renal), HCT15 (colon), MM231 (breast), NUGC-3 (gastric), NCI-H23 (lung), and PC-3 (prostate). In addition, these compounds also inhibited LPS-induced NF-kappaB transcriptional activity. The +M effect and hydrophobic groups on the N-phenyl ring potentiated the anticancer activity and NF-kappaB inhibitory activity, respectively. However, according to the results of structure-activity relationship studies, only benzofuran-2-carboxylic acid N-(4?-hydroxy)phenylamide (3m) was the lead scaffold with both an outstanding anticancer activity and NF-kappaB inhibitory activity. This novel lead scaffold may be helpful for investigation of new anticancer agents that act through inactivation of NF-kappaB.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 496-41-3. In my other articles, you can also check out more blogs about 496-41-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1769O – PubChem