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An efficient method for the iron(III) porphyrin catalyzed olefination of various aldehydes with 2,2,2-trifluorodiazoethane under neutral conditions is described. This transformation was shown to have a broad substrate scope and provide the corresponding CF3-substituted alkenes in good yields. The number of equivalents of PPh3 that is used in this reaction is crucial to the success of the olefination process. This reaction is a useful supplement to the synthetic applications of CF3CHN2.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H934O – PubChem

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Provided are 4”-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H698O – PubChem

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Styryl-like compounds showing improved stability and prolonged lifetime on repetition of the coloration and bleaching cycle and represented by the general formula STR1 in which R represents an alkyl or phenyl group, R1 and R2 independently represent a lower alkyl group, a hydroxyalkyl group, or an alkoxyalkyl group, R3 represents hydrogen, an alkyl group, a halogen, a nitrile group, an aromatic group or a phenoxy group, Y represents O or S, Z represents an alkylene radical of 2 to 4 carbon atoms, with or without alkyl substituent(s), necessary for forming a ring structure together with STR2 A represents a residue of an aromatic aldehyde, a heterocyclic aldehyde, an aromatic nitroso compound or a heterocyclic nitroso compound, and n is an integer of 2 or 3.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H715O – PubChem

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A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H710O – PubChem

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Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H656O – PubChem

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Cross-coupling of aromatic aldehydes or benzoins with unactivated imines catalyzed by an N-heterocyclic carbene (NHC) affords alpha-amino ketones smoothly. The Royal Society of Chemistry.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H920O – PubChem

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Benzofuran derivatives and benzofuransare presented as scaffolds in complex molecules and have attracted much attention and prevalent interest due to their interesting biological activity. They also exist in several numbers of naturally occurring compounds and exhibiting biological activity. In this review, we will try to underscore the reactivity of benzofurans through comprehension and giving a full perspective to the readers.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H849O – PubChem

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Four aryl vinyl diethyl benzylphosphonates related to Fostedil were synthesized and evalued for their in vitro calcium-inhibitory activity.None of these compounds exhibited any calcium antagonistic profile.Unlike a series of diethyl-styryl benzylphosphonates, previously described, the presence of two aromatic ring linked by a vinyl group did not improve the calcium antagonistic activity.Keywords: Calcium antagonist; Diethyl benzylphosphonate; Vinyl group

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1072O – PubChem

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A novel copper-catalyzed, multiple oxidative dehydrogenative functionalization of arylacetaldehydes leading to 2-oxo-acetamidine compounds has been developed. This transformation is highly efficient with dissociation of six hydrogens including two sp3 C-H and one sp2 C-H bond activations. This method not only provides an efficient approach to 2-oxo-acetamidine compounds, but also offers a valuable mechanistic insight into this novel copper catalysis. Copyright

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1129O – PubChem

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Plinabulin, a synthetic analog of the marine natural product ?diketopiperazine phenylahistin,? displayed depolymerization effects on microtubules and targeted the colchicine site, which has been moved into phase III clinical trials for the treatment of non-small cell lung cancer (NSCLC) and the prevention of chemotherapy-induced neutropenia (CIN). To develop more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives were summarized and analyzed. We performed further modifications of the tert-butyl moiety or C-ring of imidazole-type derivatives to build a library of molecules through the introduction of different groups for novel skeletons. Our structure?activity relationship study indicated that compounds 17o (IC50 = 14.0 nM, NCI-H460) and 17p (IC50 = 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-methyl or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-butyl moiety at the 5-position of imidazole was essential for the activity of such compounds. Immunofluorescence assay indicated that compounds 17o and 17p could efficiently inhibit microtubule polymerization. Overall, the novel furan-diketopiperazine-type derivatives could be considered as a potential scaffold for the development of anti-cancer drugs.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H802O – PubChem