Category: 33094-66-5

The SOS chromotest: direct assay of the expression of gene sfiA as a measure of genotoxicity of chemicals was written by Quillardet, Philippe;Huisman, Olivier;D’Ari, Richard;Hofnung, Maurice. And the article was included in Biochimie in 1982.COA of Formula: C8H5NO3 This article mentions the following:

A gene fusion, placing the lacZ gene encoding β-galactosidase under the control of the sfiA promoter, was used to construct a new tester strain for genotoxic agents. The assay is performed in a few hours and involves simple enzymic assays. The dose-response curves contain a linear portion which allows the SOS Inducing Potency (SOSIP) of compounds to be defined. For the compounds tested, SOSIPs extend over 7 decades and correlate generally well with the mutagenic potency assayed in the Salmonella/microsome assay (Mutatest) and in a phage induction assay (Inductest). Sensitivities (lowest amount detected) are comparable in the SOS Chromotest and Mutatest but lower in the Inductest. Apparently, at least part of the response in the Mutatest depends on the induction of an SOS function, and most of the genotoxins are inducers of the SOS system, i.e., can lead to activation of the RecA protease. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5COA of Formula: C8H5NO3).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C8H5NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Diels-Alder reactions of nitrobenzofurans: a simple dibenzofuran Synthesis. Theoretical studies using DFT methods was written by Della Rosa, Claudia D.;Sanchez, Juan P.;Kneeteman, Maria N.;Mancini, Pedro M. E.. And the article was included in Tetrahedron Letters in 2011.Application In Synthesis of 2-Nitrobenzofuran This article mentions the following:

2- and 3-nitrobenzofurans are studied in polar thermal Diels-Alder reactions with normal electron demand using several structurally different dienes. A very strong electron-acceptor group, such as the nitro group, pushes the dienophilic character of these heterocyclic compounds Since this substituent is easily extruded under thermal conditions, this reaction sequence becomes a simple method for the preparation of families of organic compounds with heteroatom rings. Part of this work is specifically concerned with theor. studies using DFT methods. The global and local electrophilicity and nucleophilicity indexes were calculated for the dienophiles and dienes used in this study. When 2-nitrobenzofuran and 3-nitrobenzofuran were reacted with isoprene, 1-trimethylsilyloxy-1,3-butadiene and Danishefsky’s diene, under different thermal reaction conditions they showed their dienophilic character taking part in normal-demand polar DA cycloaddition reactions. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Application In Synthesis of 2-Nitrobenzofuran).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 2-Nitrobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Diels-Alder reactions of nitrobenzofurans: a simple dibenzofuran Synthesis. Theoretical studies using DFT methods was written by Della Rosa, Claudia D.;Sanchez, Juan P.;Kneeteman, Maria N.;Mancini, Pedro M. E.. And the article was included in Tetrahedron Letters in 2011.Application In Synthesis of 2-Nitrobenzofuran This article mentions the following:

2- and 3-nitrobenzofurans are studied in polar thermal Diels-Alder reactions with normal electron demand using several structurally different dienes. A very strong electron-acceptor group, such as the nitro group, pushes the dienophilic character of these heterocyclic compounds Since this substituent is easily extruded under thermal conditions, this reaction sequence becomes a simple method for the preparation of families of organic compounds with heteroatom rings. Part of this work is specifically concerned with theor. studies using DFT methods. The global and local electrophilicity and nucleophilicity indexes were calculated for the dienophiles and dienes used in this study. When 2-nitrobenzofuran and 3-nitrobenzofuran were reacted with isoprene, 1-trimethylsilyloxy-1,3-butadiene and Danishefsky’s diene, under different thermal reaction conditions they showed their dienophilic character taking part in normal-demand polar DA cycloaddition reactions. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Application In Synthesis of 2-Nitrobenzofuran).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 2-Nitrobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem