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3199-61-9, Name is Ethyl benzofuran-2-carboxylate, belongs to benzofurans compound, is a common compound. name: Ethyl benzofuran-2-carboxylateIn an article, once mentioned the new application about 3199-61-9.

Benzo- and naphthofuran carboxylates 1, 2 and carboxamides 3, 4 were synthesized and pyrolysed by flash vacuum pyrolysis at 550 and 650 C/10?2 mmHg. 2-Formylbenzonitrile 7 from benzofurans and 2-formylnaphthonitrile 14 from naphthofurans were isolated and identified as major products. The mechanism suggested for these pyrolytic reactions involves elimination of alcohol and amine from carboxylates 1, 2 and carboxamides 3, 4 respectively, followed by extrusion of CO to form phenoxy and naphthoxycarbenes that leads to 7 and 14 respectively.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3023O – PubChem

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A mild tandem oxidative functionalization of allyl aromatic hydrocarbons was accomplished using the catalytic system of Pd(OAc)2/DMA under 1 atm O2. The green twofold C-O bond formation involving double allylic C-H oxygenation unlocks opportunities for markedly different synthetic strategies. Moreover, the reaction affords aryl alpha,beta-unsaturated esters directly from readily available terminal olefins in moderate to good yields with excellent chemo- and stereoselectivities.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3058O – PubChem

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The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Abeta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Abeta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 muM, respectively) than those of Curcumin (IC50 = 0.80 muM) and IMSB (IC50 = 8.00 muM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3005O – PubChem

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A transition-metal-free base catalyzed intramolecular cyclization of 2-ynylphenols was developed for the facile synthesis of 2-substituted benzo[b]furans. Various 2-aryl and 2-alkyl substituted benzo[b]furans can be obtained with good to excellent yields using readily available Cs2CO3 as the catalyst under mild reaction conditions. The broad substrates scope and the typical maintenance of vigorous efficiency on gram scale make this protocol a potentially practical method to synthesize 2-substituted benzo[b]furans derivatives.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3041O – PubChem

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(Chemical Equation Presented) An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2- benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3009O – PubChem

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of Ethyl benzofuran-2-carboxylate, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 3199-61-9, name is Ethyl benzofuran-2-carboxylate. In an article,Which mentioned a new discovery about 3199-61-9

An efficient and straightforward method for the rapid synthesis of 2-substituted dihydrobenzofurans has been developed via reaction of sulfur ylides with o-quinone methides (o-QMs), which were generated under mild conditions. The products could be obtained in excellent yields with various kinds of sulfur ylides. This journal is

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3038O – PubChem

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Malaria eradication is a global health priority, but current therapies are not always suitable for providing a radical cure. Artemisinin has paved the way for the current malaria treatment, the so-called Artemisinin-based Combination Therapy (ACT). However, with the detection of resistance to ACT, innovative compounds active against multiple parasite species and at multiple life stages are needed. GlaxoSmithKline has recently disclosed the results of a phenotypic screening of an internal library, publishing a collection of 400 antimalarial chemotypes, termed the ?Malaria Box?. After analysis of the data set, we have carried out a medicinal chemistry campaign in order to define the structure-activity relationships for one of the released compounds, which embodies a benzothiophene-2-carboxamide core. Thirty-five compounds were prepared, and a description of the structural features responsible for the in vitro activity against different strains of P. falciparum, the toxicity, and the metabolic stability is herein reported.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3046O – PubChem

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 3199-61-9, name is Ethyl benzofuran-2-carboxylate, introducing its new discovery. Computed Properties of C11H10O3

A series of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides were prepared, using an efficient three- to five-step synthesis, and evaluated for their inhibitory activity against human cytochrome P450C24A1 (CYP24A1) hydroxylase. Inhibition ranged from IC50 0.3-72 muM compared with the standard ketoconazole IC50 0.52 muM, with the styryl derivative (11c) displaying enhanced activity (IC50 = 0.3 muM) compared with the standard, providing a useful preliminary lead for drug development.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2998O – PubChem

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A superior method for the synthesis of substituted ethyl benzofuran-2-carboxylates in 80-99% yields from substituted 2-formylphenoxy ethylcarboxylates using 0.4 equiv of commercially available P(MeNCH2CH2)3N at 70 C for 3 hours is described.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3012O – PubChem

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Alkyl 1-benzofuran-2-carboxylates were obtained in quantitative yield by reaction of 1-benzofuran with halomethanes and alcohols in the presence of iron-containing catalysts both in the presence and in the absence of radical initiators.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3032O – PubChem