Category: 14400-67-0

Chemistry, like all the natural sciences, Computed Properties of C6H8O2, begins with the direct observation of nature— in this case, of matter.14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a document, author is Lee, Jongkook, introduce the new discover.

Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives, and their pharmacological activities against lung inflammation were, for the first time, examined in vivo using lipopolysaccharide (LPS)-induced acute lung injury model. In addition, the metabolism of KVV02 was also investigated using microsomal stability test and pharmacokinetic study in rats. When orally administered, some of these compounds (30 mg/kg) showed higher inhibitory action against LPSinduced lung inflammation in mice compared to moracin M. Of them, 2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)benzofuran-6-yl acetate (KVV02) showed potent and dose-dependent inhibitory effect on the same animal model of lung inflammation at 1, 3, and 10 mg/kg. This compound at 10 mg/kg also significantly reduced IL-1 beta concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KVV02 was rapidly metabolized to 5-(6-hydroxybenzofuran-2-yl)-1,3-phenylene bis(dimethylcarbamate) (KW06) and moracin M when it was incubated with rat serum and liver microsome as expected. When KVV02 was administered to rats via intravenous or oral route, KVV06 was detected in the serum as a metabolite. Thus, it is concluded that KVV02 has potent inhibitory action against LPS-induced lung inflammation. It could behave as a potential prodrug of moracin M to effectively treat lung inflammatory disorders.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 14400-67-0. Computed Properties of C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Maridevarmath, C., V, once mentioned the application of 14400-67-0, COA of Formula: C6H8O2, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category.

Synthesis, characterization and photophysical studies on novel benzofuran-3-acetic acid hydrazide derivatives by solvatochromic and computational methods

In the present studies, synthesis of two novel benzofuran-3-acetic acid hydrazide derivatives namely, (6-methyl-benzofuran-3-yl)-acetic acid hydrazide [6MLBH] and (6-methoxy-benzofuran-3-yl)-acetic acid hydrazide [6MOBH] are reported. The probes are characterized by IR, H-1-NMR, C-13-NMR and mass spectral methods. The absorption and fluorescence maxima of novel derivatives 6MLBH and 6MOBH are determined for different solvents of varying polarity and the solvatochromic behavior and dipole moments are investigated. Stoke’s shift exhibits a red shift with increase in solvent polarity for both the probe molecules indicating a pi ->pi* transition. The ground state dipole moment (mu g) of both the molecules in gaseous phase is estimated from ab initio computations by using Gaussian 09 W software and also from solvatochromic method and the results are compared. Further, the ground state dipole moments of the probe molecules in different solvents were also estimated theoretically by using the integral equation formalism of polarizable continuum model (IEF-PCM). By using solvatochromic correlations like Lippert’s, Bakhshiev’s, Kawski-Chamma-Viallet’s and solvent polarity parameter (E-T(N)), the excited state dipole moments (mu(e)) are determined. Results show that, the excited state dipole moments (mu(e)) are higher than the ground state dipole moments (mu g) and suggest that, the probe molecules 6MLBH and 6MOBH are more polar in the excited state. The HOMO-LUMO energy gaps computed from density functional theory (DFT) and from absorption threshold wavelengths are found to be in agreement and also support intramolecular charge transfer (ICT). Using HOMO-LUMO energies, the chemical hardness (eta) of the molecules are determined and the chemical stability is discussed. Further, using DFT molecular electrostatic potential (MESP) plots, the electrophilic site and nucleophilic site which are useful in photochemical reactions were identified. The various types of interactions present between the solute-solvent were analyzed by multiple linear regression analysis using Catalan parameters. The preliminary observations and results suggest that, the probe molecules 6MLBH and 6MOBH can be considered as potential candidates for luminescence materials, fluorescent probes and for designing non-linear optical materials in future. (C) 2019 Elsevier B.V. All rights reserved.

If you are interested in 14400-67-0, you can contact me at any time and look forward to more communication. COA of Formula: C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Wang, Xiaomin, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Category: benzofurans.

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells

BackgroundPsoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects.ResultsPsoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1 alpha, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn’t inhibit the psoralen-induced ER stress in SMMC7721 cells.ConclusionsPsoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, Safety of 2,5-Dimethylfuran-3(2H)-one, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound. In a document, author is Jaradat, Nidal.

Phytochemistry, traditional uses and biological effects of the desert plant Styrax officinalis L

Styrax officinalis L. is an important medicinal plant that grows in the desert, subtropics, temperate climate, and Mediterranean Basin regions.. It has been used for medicinal, religious, agricultural and cosmetic purposes. This review aimed to collect from the literature, all the available data about the phytochemistry, traditional medicinal uses, evidence-based uses, morphology and habitat of S. officinalis plant. This report is a review of the literature concerning S. officinalis chemical constituents, description, origin, traditional medicinal and evidence-based uses published from 1966 to date. Among the databases searched for primary literature references are Pubmed, Scientific Information Database, Scopus, Web of Science, Science Direct, Google and Google scholar. In this search, combinations of the keyword Styrax officinalis with the terms; antibacterial, antifungal, antioxidant, anticancer, phytochemistry, ethnopharmacology, traditional uses, folk uses, morphology, biological activity, therapeutic effects and toxicity were applied. The current review showed that various compounds have been isolated from S. officinalis: leaves, fruits, seeds, flowers and stems such as egonol, egonol oleate, americanin, several types of phenolic acids and benzofuran derivatives. These natural compounds and their synthetic derivatives in addition to the various parts used as extracts showed valuable biological activities including antitumor, hemolytic, anti-complement, anti-leukemic, antifungal, antibacterial, antioxidant and tyrosinase inhibitory activities. This review represented a summary of the information concerning S. officinalis different used parts. However, the areas of isolation and identification of the biologically active compounds of S. officinalis from the roots and rhizomes also investigation more biological activities of other plant parts are essential to cover all the scientific fields of S. officinalis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14400-67-0. Safety of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry, like all the natural sciences, Computed Properties of C6H8O2, begins with the direct observation of nature— in this case, of matter.14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a document, author is Lee, Jongkook, introduce the new discover.

Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives, and their pharmacological activities against lung inflammation were, for the first time, examined in vivo using lipopolysaccharide (LPS)-induced acute lung injury model. In addition, the metabolism of KVV02 was also investigated using microsomal stability test and pharmacokinetic study in rats. When orally administered, some of these compounds (30 mg/kg) showed higher inhibitory action against LPSinduced lung inflammation in mice compared to moracin M. Of them, 2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)benzofuran-6-yl acetate (KVV02) showed potent and dose-dependent inhibitory effect on the same animal model of lung inflammation at 1, 3, and 10 mg/kg. This compound at 10 mg/kg also significantly reduced IL-1 beta concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KVV02 was rapidly metabolized to 5-(6-hydroxybenzofuran-2-yl)-1,3-phenylene bis(dimethylcarbamate) (KW06) and moracin M when it was incubated with rat serum and liver microsome as expected. When KVV02 was administered to rats via intravenous or oral route, KVV06 was detected in the serum as a metabolite. Thus, it is concluded that KVV02 has potent inhibitory action against LPS-induced lung inflammation. It could behave as a potential prodrug of moracin M to effectively treat lung inflammatory disorders.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 14400-67-0. Computed Properties of C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound, is a common compound. In a patnet, author is Milyutin, Constantine, V, once mentioned the new application about 14400-67-0, Recommanded Product: 14400-67-0.

Synthesis of 1H-pyrano[4,3-b]benzofuran-1-one derivatives via photochemical cyclization of substituted 4H-furo[3,2-c]pyran-4-ones

A novel approach for synthesis of fused 1H-pyrano[4,3-b]benzofuran-1-ones was developed based on the photochemical reaction of 2,3-disubstitued 4H-furo[3,2-c]pyran-4-ones. The studied process includes the photocyclization of the hexatriene system and subsequent aromatization of benzene ring via elimination of water molecule. The structure of one of the 1H-pyrano[4,3-b]benzofuran-1-one derivatives was determined by X-ray diffraction. (C) 2020 Elsevier Ltd. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 14400-67-0. The above is the message from the blog manager. Recommanded Product: 14400-67-0.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is , belongs to benzofurans compound. In a document, author is Ncube, Efficient N., Quality Control of 2,5-Dimethylfuran-3(2H)-one.

Ambrafuran (Ambrox(TM)) Synthesis from Natural Plant Product Precursors

Ambergris, an excretion product of sperm whales, has been a valued agent in the formulation of perfumes. The composition of ambergris consists of two major components: 40-46% cholestanol type steroids and approximately 25-45% of a triterpenoid known as ambrein. Ambergris undergoes oxidative decomposition in the environment to result in odorous compounds, such as ambraoxide, methylambraoxide, and ambracetal. Its oxidized form, ambrafuran (IUPAC name: 3a,6,6,9a-tetramethyl-2,4,5,5a,7,8,9,9b-octahydro-1H-benzo[e][1]benzofuran), is a terpene furan with a pleasant odor and unique olfactive and fixative properties. The current state of the fragrance industry uses ambrafuran materials entirely from synthetic or semisynthetic sources. However, natural compounds with the potential to be converted to ambergris-like odorants have been extracted from several different types of plants. Here we review plant terpenoids suitable as starting materials for the semisyntheses of ambrafuran or intermediates, such as ambradiol, that can be used in biocatalytic transformations to yield ambrafuran.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14400-67-0, in my other articles. Quality Control of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Electric Literature of 14400-67-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a article, author is Liu, Jun, introduce new discover of the category.

Photovoltaic Performance of 4,8-Bis(2 ‘-ethylhexylthiophene)thieno[2,3-f]benzofuran-Based Dyes Fabricated with Different Donors in Dye-Sensitized Solar Cells

Thieno[2,3-f]benzofuran (BDF) has the advantages of a highly planarized structure, strong electron-donating ability, high hole mobility, good conjugation, and a wide spectral response range. In recent years, BDF has been widely used in organic solar cells, especially in bulk-heterojunction (BHJ) organic solar cells. In this work, a model molecule PSB-1 was synthesized based on this highly planar fragment and used as a photosensitizer in dye-sensitized solar cells (DSCs), then different aromatic amine donors such as triphenylamine (TPA), carbazole (CZ), and phenothiazine (PTZ) were introduced to the end of PSB-1, and a series of dyes PSB-2, PSB-3, and PSB-4 were designed and synthesized. After that, the relationship among the molecular structure, energy level, and photovoltaic performance of the benzo-[1,2-b:4,5-b’]dithiophene (BDT) dye was studied by theoretical calculations, photophysics, electrochemistry, and photovoltaic properties. The results show that the introduction of a strong donor can effectively improve the energy level, absorption spectrum, and photovoltaic performance of PSB-1. Through the preliminary test, we found that the energy conversion efficiency (photovoltaic conversion efficiency-PCE) of PSB-4 is up to 5.5%, which is nearly 90% higher than that of PSB-1 (PCE = 2.9%), while the introduction of a weak donor greatly weakens the effect, in which the PCE of PSB-3 is 3.5%, which is only 20% higher than that of the model molecule. By an analysis of the molecular frontier orbital distribution using theoretical calculations, we found that the electron cloud of the highest occupied orbital level (highest occupied molecular orbital-HOMO) of PSB-3 is mainly distributed on the BDF group so that the electron transfer of excited-state molecules mainly occurs from the BDF to the receptor (CA).

Electric Literature of 14400-67-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 14400-67-0 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Shi, Xuetao, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Category: benzofurans.

Chemical pathways for the formation of benzofuran and dibenzofuran in combustion

Understanding and predicting the formation of polycyclic aromatic compounds (PACs) and their role in the formation of high molecular mass compounds is still an unresolved topic in combustion. PACs characteristics, such as chemical composition, size, and presence of side chains, play an important role not only in terms of environmental and health impact, but also when developing models that describe the formation of nanoparticles and soot. In this paper, we report on a detailed analysis of the reaction pathways describing the chemistry of furan-embedded PACs using ab initio G3-type electronic structure calculations leading to the formation of benzofuran and dibenzofuran from benzene and biphenyl. The 82 elementary reactions, identified in this work, contain unexplored pathways involving triplet oxygen atom and hydroxyl radical addition reactions. A protocol for improving the calculations of reaction energetics from ab initio compound methods is proposed, which consists of the thorough usage of IRCmax scheme to identify the transition state structure and an energy correction (similar to 0.2 kcal/mol) to the empirical term in G3 formula for systems with open-shell singlet type of electronic configurations. Based on these ab initio calculations, temperature dependent reaction rate constants are calculated according to statistical theories, together with thermodynamics data. Branching ratio analysis based on steady-state approximation is carried out to illustrate the relative importance of the new pathways in an ethylene premixed flame. Results show that the newly discovered benzofuran formation pathways can play a relative important role when in presence of phenol or phenoxyl radicals at various locations in the flame. (C) 2019 Published by Elsevier Inc. on behalf of The Combustion Institute.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14400-67-0, Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Zhu, Tianhan, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Product Details of 14400-67-0.

Preparation of NiCu Alloy Catalyst for the Hydrodeoxygenation of Benzofuran

A series of bimetallic NixCu(10-x)/SiO2(wherexis the mass fraction of Ni and the total metal loading was fixed at 10 wt%.) catalysts with different Ni/Cu mass ratio are prepared and characterized by X-Ray diffraction (XRD), N(2)adsorption-desorption, inductively coupled plasma mass spectrometry (ICP-MS), H(2)temperature-programmed reduction (H-2-TPR) and transmission electron microscope (TEM). The benzofuran (BF) hydrodeoxygenation (HDO) performance of as-prepared catalysts are evaluated in a fixed flow reactor. The results showed that the incorporation of Cu to Ni/SiO(2)catalyst can increase surface area of catalyst and improve the reducibility of nickel oxide species, which contributed to higher catalytic activity and total deoxygenated compounds yield. Moreover, the strong synergistic effect between Ni and Cu led to the formation of NiCu alloy at the Ni mass fraction of 5 wt% and thus induced smaller crystallite size and exposure of more active particles, which inevitably contributed to the improved HDO performance for Ni5Cu5/SiO(2)catalyst. At 300 degrees C, 3.0 MPa, MHSV=3.0 h(-1)and H-2/oil = 500(v/v), the total yield of deoxygenated products over Ni5Cu5/SiO(2)catalyst reached 86.0%, which is increased by 10.8% and 77.4% as compared to those of monometallic Ni/SiO2(75.2%) and Cu/SiO(2)catalysts (8.8%), respectively. Finally, a possible reaction network for HDO of BF on Ni5Cu5/SiO(2)catalyst was proposed. [GRAPHICS] .

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem