Category: 14400-67-0

Electric Literature of 14400-67-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a article, author is Palu, Doreen Stacy, introduce new discover of the category.

Three new compounds, a dihydrobenzofuran (coumaran) derivative (compound1) and two pterocarpans (compounds2and3) were isolated from a root extract ofCalicotome villosagrowing wild in Corsica. Their structures were elucidated using 1D and 2D NMR spectroscopy and MS/MS as 2-(1-methylethenyl)-5-hydroxy-6-carbomethoxy-2,3-dihydro-benzofuran, 4,9-dihydroxy-3-methoxy-2-dimethylallylpterocarpan, and 4,9-dihydroxy-3 ‘,3 ‘-dimethyl-2,3-pyranopterocarpan.

Electric Literature of 14400-67-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 14400-67-0 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Reference of 14400-67-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a article, author is Li, Yiyang, introduce new discover of the category.

CHEMICAL COMPOSITIONS AND FUNCTIONS OF CHINESE FIR VOLATILES

Chinese fir is an important economic tree species in China. In addition to the application of alive trees and wood, the abundant chemical compositions of Chinese fir as a non-wood resource also have very important position. This study used Chinese fir wood powder as material, analyzing the chemical composition of Chinese fir volatiles by Fourier transform infrared spectroscopy (FT-IR), thermogravimetry (TG), pyrolisis-gas chromatography-mass spectrometry (Py-GC-MS), thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS). Through the analysis of the detected we can know that volatiles main were phenolic (cedrol, alpha-bisabolol and beta-eudesmol), ester (dimethyl phthalate, diisobutyl phthalate and dibutyl phthalate), ketone (hydroxyacetone and benzofuran) and aldehyde (hexanal and nonanal) and so on. This compounds and their derivatives can use at wide medical, biology, cosmetics and textile industry.

Reference of 14400-67-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 14400-67-0 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, formurla is C6H8O2. In a document, author is Albano, Gianluigi, introducing its new discovery. HPLC of Formula: C6H8O2.

From Alkynes to Heterocycles through Metal-Promoted Silylformylation and Silylcarbocyclization Reactions

Oxygen and nitrogen heterocyclic systems are present in a large number of natural and synthetic compounds. In particular, oxa- and aza-silacyclane, tetrahydrofuran, benzofuran, cycloheptadifuranone, cycloheptadipyrrolone, pyrrolidine, lactone, lactam, phthalan, isochromanone, tetrahydroisoquinolinone, benzoindolizidinone, indoline and indolizidine scaffolds are present in many classes of biologically active molecules. Most of these contain a C=O moiety which can be easily introduced using carbonylative reaction conditions. In this field, intramolecular silylformylation and silylcarbocyclization reactions may afford heterocyclic compounds containing a carbonyl functional group together with a vinylsilane moiety which can be further transformed. Considering these two aspects, in this review a detailed analysis of the literature data regarding the application of silylformylation and silylcarbocyclization reactions to the synthesis of several heterocyclic derivatives is reported.

If you are hungry for even more, make sure to check my other article about 14400-67-0, HPLC of Formula: C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Maridevarmath, C., V, once mentioned the application of 14400-67-0, COA of Formula: C6H8O2, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category.

Synthesis, characterization and photophysical studies on novel benzofuran-3-acetic acid hydrazide derivatives by solvatochromic and computational methods

In the present studies, synthesis of two novel benzofuran-3-acetic acid hydrazide derivatives namely, (6-methyl-benzofuran-3-yl)-acetic acid hydrazide [6MLBH] and (6-methoxy-benzofuran-3-yl)-acetic acid hydrazide [6MOBH] are reported. The probes are characterized by IR, H-1-NMR, C-13-NMR and mass spectral methods. The absorption and fluorescence maxima of novel derivatives 6MLBH and 6MOBH are determined for different solvents of varying polarity and the solvatochromic behavior and dipole moments are investigated. Stoke’s shift exhibits a red shift with increase in solvent polarity for both the probe molecules indicating a pi ->pi* transition. The ground state dipole moment (mu g) of both the molecules in gaseous phase is estimated from ab initio computations by using Gaussian 09 W software and also from solvatochromic method and the results are compared. Further, the ground state dipole moments of the probe molecules in different solvents were also estimated theoretically by using the integral equation formalism of polarizable continuum model (IEF-PCM). By using solvatochromic correlations like Lippert’s, Bakhshiev’s, Kawski-Chamma-Viallet’s and solvent polarity parameter (E-T(N)), the excited state dipole moments (mu(e)) are determined. Results show that, the excited state dipole moments (mu(e)) are higher than the ground state dipole moments (mu g) and suggest that, the probe molecules 6MLBH and 6MOBH are more polar in the excited state. The HOMO-LUMO energy gaps computed from density functional theory (DFT) and from absorption threshold wavelengths are found to be in agreement and also support intramolecular charge transfer (ICT). Using HOMO-LUMO energies, the chemical hardness (eta) of the molecules are determined and the chemical stability is discussed. Further, using DFT molecular electrostatic potential (MESP) plots, the electrophilic site and nucleophilic site which are useful in photochemical reactions were identified. The various types of interactions present between the solute-solvent were analyzed by multiple linear regression analysis using Catalan parameters. The preliminary observations and results suggest that, the probe molecules 6MLBH and 6MOBH can be considered as potential candidates for luminescence materials, fluorescent probes and for designing non-linear optical materials in future. (C) 2019 Elsevier B.V. All rights reserved.

If you are interested in 14400-67-0, you can contact me at any time and look forward to more communication. COA of Formula: C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Wang, Xiaomin, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Category: benzofurans.

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells

BackgroundPsoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects.ResultsPsoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1 alpha, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn’t inhibit the psoralen-induced ER stress in SMMC7721 cells.ConclusionsPsoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14400-67-0, Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, Safety of 2,5-Dimethylfuran-3(2H)-one, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound. In a document, author is Jaradat, Nidal.

Phytochemistry, traditional uses and biological effects of the desert plant Styrax officinalis L

Styrax officinalis L. is an important medicinal plant that grows in the desert, subtropics, temperate climate, and Mediterranean Basin regions.. It has been used for medicinal, religious, agricultural and cosmetic purposes. This review aimed to collect from the literature, all the available data about the phytochemistry, traditional medicinal uses, evidence-based uses, morphology and habitat of S. officinalis plant. This report is a review of the literature concerning S. officinalis chemical constituents, description, origin, traditional medicinal and evidence-based uses published from 1966 to date. Among the databases searched for primary literature references are Pubmed, Scientific Information Database, Scopus, Web of Science, Science Direct, Google and Google scholar. In this search, combinations of the keyword Styrax officinalis with the terms; antibacterial, antifungal, antioxidant, anticancer, phytochemistry, ethnopharmacology, traditional uses, folk uses, morphology, biological activity, therapeutic effects and toxicity were applied. The current review showed that various compounds have been isolated from S. officinalis: leaves, fruits, seeds, flowers and stems such as egonol, egonol oleate, americanin, several types of phenolic acids and benzofuran derivatives. These natural compounds and their synthetic derivatives in addition to the various parts used as extracts showed valuable biological activities including antitumor, hemolytic, anti-complement, anti-leukemic, antifungal, antibacterial, antioxidant and tyrosinase inhibitory activities. This review represented a summary of the information concerning S. officinalis different used parts. However, the areas of isolation and identification of the biologically active compounds of S. officinalis from the roots and rhizomes also investigation more biological activities of other plant parts are essential to cover all the scientific fields of S. officinalis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14400-67-0. Safety of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry, like all the natural sciences, Computed Properties of C6H8O2, begins with the direct observation of nature— in this case, of matter.14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a document, author is Lee, Jongkook, introduce the new discover.

Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives, and their pharmacological activities against lung inflammation were, for the first time, examined in vivo using lipopolysaccharide (LPS)-induced acute lung injury model. In addition, the metabolism of KVV02 was also investigated using microsomal stability test and pharmacokinetic study in rats. When orally administered, some of these compounds (30 mg/kg) showed higher inhibitory action against LPSinduced lung inflammation in mice compared to moracin M. Of them, 2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)benzofuran-6-yl acetate (KVV02) showed potent and dose-dependent inhibitory effect on the same animal model of lung inflammation at 1, 3, and 10 mg/kg. This compound at 10 mg/kg also significantly reduced IL-1 beta concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KVV02 was rapidly metabolized to 5-(6-hydroxybenzofuran-2-yl)-1,3-phenylene bis(dimethylcarbamate) (KW06) and moracin M when it was incubated with rat serum and liver microsome as expected. When KVV02 was administered to rats via intravenous or oral route, KVV06 was detected in the serum as a metabolite. Thus, it is concluded that KVV02 has potent inhibitory action against LPS-induced lung inflammation. It could behave as a potential prodrug of moracin M to effectively treat lung inflammatory disorders.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 14400-67-0. Computed Properties of C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Maridevarmath, C., V, once mentioned the application of 14400-67-0, COA of Formula: C6H8O2, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category.

Synthesis, characterization and photophysical studies on novel benzofuran-3-acetic acid hydrazide derivatives by solvatochromic and computational methods

In the present studies, synthesis of two novel benzofuran-3-acetic acid hydrazide derivatives namely, (6-methyl-benzofuran-3-yl)-acetic acid hydrazide [6MLBH] and (6-methoxy-benzofuran-3-yl)-acetic acid hydrazide [6MOBH] are reported. The probes are characterized by IR, H-1-NMR, C-13-NMR and mass spectral methods. The absorption and fluorescence maxima of novel derivatives 6MLBH and 6MOBH are determined for different solvents of varying polarity and the solvatochromic behavior and dipole moments are investigated. Stoke’s shift exhibits a red shift with increase in solvent polarity for both the probe molecules indicating a pi ->pi* transition. The ground state dipole moment (mu g) of both the molecules in gaseous phase is estimated from ab initio computations by using Gaussian 09 W software and also from solvatochromic method and the results are compared. Further, the ground state dipole moments of the probe molecules in different solvents were also estimated theoretically by using the integral equation formalism of polarizable continuum model (IEF-PCM). By using solvatochromic correlations like Lippert’s, Bakhshiev’s, Kawski-Chamma-Viallet’s and solvent polarity parameter (E-T(N)), the excited state dipole moments (mu(e)) are determined. Results show that, the excited state dipole moments (mu(e)) are higher than the ground state dipole moments (mu g) and suggest that, the probe molecules 6MLBH and 6MOBH are more polar in the excited state. The HOMO-LUMO energy gaps computed from density functional theory (DFT) and from absorption threshold wavelengths are found to be in agreement and also support intramolecular charge transfer (ICT). Using HOMO-LUMO energies, the chemical hardness (eta) of the molecules are determined and the chemical stability is discussed. Further, using DFT molecular electrostatic potential (MESP) plots, the electrophilic site and nucleophilic site which are useful in photochemical reactions were identified. The various types of interactions present between the solute-solvent were analyzed by multiple linear regression analysis using Catalan parameters. The preliminary observations and results suggest that, the probe molecules 6MLBH and 6MOBH can be considered as potential candidates for luminescence materials, fluorescent probes and for designing non-linear optical materials in future. (C) 2019 Elsevier B.V. All rights reserved.

If you are interested in 14400-67-0, you can contact me at any time and look forward to more communication. COA of Formula: C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Wang, Xiaomin, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Category: benzofurans.

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells

BackgroundPsoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects.ResultsPsoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1 alpha, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn’t inhibit the psoralen-induced ER stress in SMMC7721 cells.ConclusionsPsoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14400-67-0, Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, Safety of 2,5-Dimethylfuran-3(2H)-one, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound. In a document, author is Jaradat, Nidal.

Phytochemistry, traditional uses and biological effects of the desert plant Styrax officinalis L

Styrax officinalis L. is an important medicinal plant that grows in the desert, subtropics, temperate climate, and Mediterranean Basin regions.. It has been used for medicinal, religious, agricultural and cosmetic purposes. This review aimed to collect from the literature, all the available data about the phytochemistry, traditional medicinal uses, evidence-based uses, morphology and habitat of S. officinalis plant. This report is a review of the literature concerning S. officinalis chemical constituents, description, origin, traditional medicinal and evidence-based uses published from 1966 to date. Among the databases searched for primary literature references are Pubmed, Scientific Information Database, Scopus, Web of Science, Science Direct, Google and Google scholar. In this search, combinations of the keyword Styrax officinalis with the terms; antibacterial, antifungal, antioxidant, anticancer, phytochemistry, ethnopharmacology, traditional uses, folk uses, morphology, biological activity, therapeutic effects and toxicity were applied. The current review showed that various compounds have been isolated from S. officinalis: leaves, fruits, seeds, flowers and stems such as egonol, egonol oleate, americanin, several types of phenolic acids and benzofuran derivatives. These natural compounds and their synthetic derivatives in addition to the various parts used as extracts showed valuable biological activities including antitumor, hemolytic, anti-complement, anti-leukemic, antifungal, antibacterial, antioxidant and tyrosinase inhibitory activities. This review represented a summary of the information concerning S. officinalis different used parts. However, the areas of isolation and identification of the biologically active compounds of S. officinalis from the roots and rhizomes also investigation more biological activities of other plant parts are essential to cover all the scientific fields of S. officinalis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14400-67-0. Safety of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem