One-pot synthesis of novel symmetric 1,5-di(benzofuran-2-yl)-3-(4-substituted-aryl)-pentane-1,5-dione derivatives was written by Aruna, Kumar D. B.;Desai, Nivedita R.;Krishnaswamy, G.;Sreenivasa, S.;Mahadevan, K. M.. And the article was included in Indian Journal of Chemistry in 2014.Product Details of 38220-75-6 This article mentions the following:
Cyclocondensation of 5-R-2-hydroxybenzaldehydes (R = H, Cl, Br, O2N) with bromoacetone under basic conditions in ethanol afforded the corresponding 5-R-2-acetylbenzofurans. Subsequent cross-aldol reaction/Michael addition of the latter with various aromatic aldehydes 4-R1C6H4CHO (R1 = H, Cl, O2N, MeO) by grinding in the presence of a base in min. amount of acetonitrile at room temperature afforded novel sym. 1,5-di(benzofuran-2-yl)-3-arylpentane-1,5-diones I. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Product Details of 38220-75-6).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 38220-75-6
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem