The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide(SMILESS: O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+],cas:129-18-0) is researched.Related Products of 1265884-98-7. The article 《Influence of various drugs on the tissue permeability. II》 in relation to this compound, is published in Nippon Yakurigaku Zasshi. Let’s take a look at the latest research on this compound (cas:129-18-0).
The effects of drugs containing antiinflammatory agents administrated systemically on the dermal connective tissue permeability in rats were tested by a spreading method based on the rate of diffusion of Evans blue solution after intradermal injection. Antiinflammatory agents decreased the tissue permeability following s.c. and oral administration. In most cases, there were dose-response relations. Intensity of the inhibitory effect of the tissue permeability was in the order: dexamethasone, indometacin (I), prednisolone, phosphate, Na bucolome (II), hydrocortisone acetate (III), Na, phenylbutazone, flufenamic acid, N-(o-methoxybenzoyl)glycine dimethylamide, benzydamine-HCl (IV), 4-chloro-5-sulfamoyl-anthranilic acid, mefenamic acid, aminopyrine (V), acetylsalicylic acid (VI), Na salicylate (VII), pronase AS, and bromelain. When II, III, V, and VII were combined with l-ascorbic acid their inhibitory effects were enhanced in both s.c. and oral administration, while the inhibitory effect in oral administration of I, IV, and VI was enhanced.
This literature about this compound(129-18-0)Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idehas given us a lot of inspiration, and I hope that the research on this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem