Aelenei, Petruta published the artcileMorus alba leaf extract: Metabolite profiling and interactions with antibiotics against Staphylococcus spp. including MRSA, SDS of cas: 56317-21-6, the publication is Phytochemistry Letters (2019), 217-224, database is CAplus.
HPLC-DAD-ESI-Q-TOF-MS/MS metabolite profiling of Morus alba leaf extract led to the annotation of 25 constituents (two stilbene derivatives, 11 prenylflavonoids, five 2-arylbenzofurans, seven Diels-Alder type adducts). The extract was found to contain 57.83 mg/g flavonoids, 15.42 mg/g kuwanon G and 10.47 mg/g morusin. Despite its moderate antibacterial activity with min. inhibitory concentration (MIC) values of 250μg/mL against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33591 and ATCC 43300, methicillin-susceptible S. aureus (MSSA) ATCC 6538 and S. epidermidis ATCC 12228, Morus alba leaf extract reversed oxacillin-resistance of MRSA ATCC 43300. In addition, the extract showed synergy with gentamicin against MRSA ATCC 33591 and ATCC 43300 and S. epidermidis ATCC 12228, oxacillin against MRSA ATCC 33591 and tetracycline against S. epidermidis ATCC 12228. In these synergistic combinations, MIC values of antibiotics were significantly decreased (4-32-fold). These findings might be valuable for the development of novel treatment strategies in infections caused by MRSA and S. epidermidis.
Phytochemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, SDS of cas: 56317-21-6.
Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem