Day: March 23, 2021

Synthetic Route of 97148-39-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, SMILES is O=C([O-])/C(C1=CC=CO1)=NOC.[NH4+], belongs to benzofurans compound. In a article, author is Boyd, Derek R., introduce new discover of the category.

Cis-Dihydroxylation of Tricyclic Arenes and Heteroarenes Catalyzed by Toluene Dioxygenase: A Molecular Docking Study and Experimental Validation

Molecular docking studies of toluene dioxygenase led to the prediction that angular and lateral cis-dihydroxylation of tricyclic arene and heteroarene substrates could occur. Biotransformations of biphenylene, dibenzofuran, carbazole and dibenzothiophene, using Pseudomonas putida UV4 whole cells, expressing toluene dioxygenase, confirmed that both angular and lateral cis-dihydroxylation had occurred in the predicted regioselective and stereoselective manner. The toluene dioxygenase-catalysed (Pseudomonas putida UV4) biotransformation of dibenzofuran was optimized, to produce 1,2-dihydrodibenzofuran-1,2-diol as the major metabolite in excellent yield. 2-Hydroxydibenzofuran, resulting from dehydration of 1,2-dihydrodibenzofuran-1,2-diol, was also found to undergo cis- dihydroxylation to give a very minor cis-dihydrodiol metabolite. The enantiopurity (>98% ee) and (1R,2S) absolute configuration of the major dibenzofuran cis -dihydrodiol was rigorously established by catalytic hydrogenation and formation of methoxy(trifluoromethyl)phenylacetate derivatives and by X-ray crystallography of an epoxide derivative. Biotransformation of carbazole yielded anthranilic acid as the major metabolite and was consistent with angular cis-dihydroxylation. Synthesis of a cis- diol epoxide derivative showed that the main cis-dihydrodiol metabolite of dibenzofuran has potential in the chemoenzymatic synthesis of natural products.

Synthetic Route of 97148-39-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 97148-39-5.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a document, author is Shigeno, Masanori, introduce the new discover, Recommanded Product: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide.

Double-Carboxylation of Two C-H Bonds in 2-Alkylheteroarenes Using LiO-t-Bu/CsF

We describe the double-carboxylation of two C-H bonds (i.e., at the benzylic and the beta-positions) in 2-alkylheteroarenes using a combination of LiO-t-Bu and CsF. A diverse range of substrates, namely benzothiophene, thiophene, benzofuran, furan, and indole derivatives, are efficiently converted into the doubly carboxylated products. A variety of functionalities (i.e., methyl, methoxy, halogen, cyano, ester, ketone, and amide moieties) are well tolerated.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6296-53-3 is helpful to your research. Recommanded Product: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application of 97148-39-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, SMILES is O=C([O-])/C(C1=CC=CO1)=NOC.[NH4+], belongs to benzofurans compound. In a article, author is Bhukya, Balakishan, introduce new discover of the category.

Design, synthesis, in vitro and in silico studies of 2, 3-diaryl benzofuran derivatives as antitubercular agents

As a part of our drug discovery program for anti-tubercular agents, a total of seventeen 2, 3-diaryl benzofuran hybrids were designed, synthesized and screened for their anti-tubercular potential against Mycobacterium tuberculosis H37Ra avirulent strain. Out of seventeen, four derivatives showed significant activity against M. tuberculosis H37Ra avirulent strain (ATCC 25177) with MIC value ranging from 12.5 to 50 mu g/mL but out of four, one derivative (9E) was significantly active (MIC 12.5 mu g/mL), which was further supported by the molecular docking energy (-8.4 kcal/mol) with respect to the first line anti-tubercular drug, isoniazid (-6.2 kcal/mol) on the target Polyketide Synthase-13. All the derivatives were also evaluated for their cytotoxicity against the normal lung cell line L-132 by the MTT assay and no toxicity was observed up to 27.4 mu g/mL concentration. This report on the antitubercular potential of benzofuran derivatives may be of great help in anti-tubercular drug development.

Application of 97148-39-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 97148-39-5 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, in an article , author is Kolodziejska, Renata, once mentioned of 87-41-2, Name: Isobenzofuran-1(3H)-one.

Effect of chemical structure of benzofuran derivatives and reaction conditions on enantioselective properties of Aureobasidium pullulans microorganism contained in Boni Protect antifungal agent

Bioorganic asymmetric reduction of carbonyl compounds is one of the most important fundamental and practical reactions for producing chiral alcohols. The stereoselective bioreduction of prochiral ketones of benzofuran derivatives in the presence of yeast-like fungus Aureobasidium pullulans contained in the antifungal Boni Protect agent was studied. Biotransformations were carried out under moderate conditions in an aqueous and two-phase system and without multiplication of the bioreagent. Despite similar chemical structure, each of the used ketone has been reduced with varying efficiency and selectivity. One of the reasons for these results is the presence of a whole set of oxidoreductases in A. pullulans cells that are sensitive to the smallest changes in the structure of prochiral substrate. The unsymmetrical methyl ketones were biotransformed with the highest selectivity. Aureobasidium pullulans microorganism is less effective in the reduction of unsymmetrical halomethyl ketones. The presence of a heteroatom in the alkyl group significantly decreases the selectivity of the process. Finally, as a result of the preferred hydride ion transfer from the dihydropyridine ring of the cofactor to the carbonyl double bond on the re side, secondary alcohols of the S and R configuration were obtained with moderate to high enantioselectivity (55-99%).

Interested yet? Read on for other articles about 87-41-2, you can contact me at any time and look forward to more communication. Name: Isobenzofuran-1(3H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 591-11-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a article, author is Verma, Kama, introduce new discover of the category.

Exploitation of donor-acceptor cyclopropanes and N-sulfonyl 1-azadienes towards the synthesis of spiro-cyclopentane benzofuran derivatives

A MgI2 catalyzed formal [3 + 2] cycloaddition reaction between donor-acceptor cyclopropanes and N-sulfonyl 1-azadienes towards the synthesis of highly functionalized spiro-cyclopentane benzofuran derivatives has been developed. This methodology is appreciated in terms of chemoselectivity and mild reaction conditions. In addition, hydrolysis of one of the N-sulfonyl derivatives offered the corresponding spiro dihydrofuran-3-one derivative in the presence of basic alumina.

Related Products of 591-11-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 591-11-7.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2. In an article, author is Marais, Lindie,once mentioned of 4412-91-3, Recommanded Product: 4412-91-3.

The development of a Cu(I)/pyrazolylpyridineamine catalyst system for the hydroxylation of aryl halides

A catalyst system comprising of pyrazolylpyridineamine/Cu(I)/CsOH is reported. for the hydroxylation of aryl iodides and bromides with moderate to outstanding yields, without the use of an inert atmosphere. A comprehensive parameter optimisation study established optimum component concentrations: [Cu(MeCN)(4)]BF4 and 2-(1H-pyrazol-1-yl)-N-(pyridine-2-ylmethyl)ethan-1-amine (L01) (2 mol %), substrate (1 mmol), CsOH (4 mmol) and DMSO:H2O (1:1, 3 mL). Monitoring substrate conversion as a function of time revealed an induction period of 90 min, which could be eliminated through the initial in situ formation of the proposed [(L01)Cu-OH] intermediate. Eliminating the induction period resulted in complete conversion within one hour, with turnover numbers exceeding that of the benchmark catalyst system operating at an optimal catalyst loading of 0.05 mol %.

Interested yet? Keep reading other articles of 4412-91-3, you can contact me at any time and look forward to more communication. Recommanded Product: 4412-91-3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is , belongs to benzofurans compound. In a document, author is Su, Yan, Recommanded Product: 14400-67-0.

Crystalline and Stable Benzofuran-Linked Covalent Organic Frameworks from Irreversible Cascade Reactions

We report the synthesis of crystalline two-dimensional covalent organic frameworks (COFs) by connecting hydroxybenzene-aldehyde and acetonitrile building blocks to form cyano-substituted benzofuran linkages. Unlike the majority of COFs that were synthesized based on condensation reactions, the COFs in this report are crystallized from irreversible cascade reactions involving consecutive cyanide migration, ring-closure, and oxidation reactions. The irreversible property endows the COFs with high chemical stability in both acid and base and allows them to be postsynthetically modified to install predesigned functionality under harsh conditions. We highlight that the functionalized COFs serve as exceptional vehicles for superprotonic conductions.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 497-23-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Ibrahim, Magdy A., introduce new discover of the category.

Chemical behavior of 4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromene-6-carboxaldehyde towards carbon nucleophilic reagents

The chemical behavior of 6-formylkhellin (1) was investigated toward a variety of carbon nucleophiles. Treatment of aldehyde 1 with cyanoacetamide, N-benzylcyanoacetamide produced pyridine-3-carboxamides 3 and 4. Treatment of carboxaldehyde 1 with malononitrile dimer and 1H-benzimidazol-2-ylacetonitrile gave 1,6-naphthyridine 5 and pyrido[1,2-a]benzimidazole 6, respectively. Some novel pyrazolo[3,4-b]pyridine 7, pyrido[2,3-d]pyrimidines 8 and 9 were synthesized from the ring opening ring closure reactions of carboxaldehyde 1 with certain heterocyclic enamines. In addition, reaction of carboxaldehyde 1 with certain cyclic enols produced a variety of products. Treatment of carboxaldehyde 1 with 1,3-cyclohexanediones gave xanthene-1,8-diones 19 and 20. Reaction of carboxaldehyde 1 with 5-methyl-2,4-dihydro-3H-pyrazol-3-one proceeds in 1:2 M ratio producing pyrazolo [4 ‘,3 ‘:5,6]pyrano[2,3-c]pyrazole derivative 22. Carboxaldehyde 1 reacted with certain heterocyclic compounds containing active methylene groups to give the corresponding condensation products 22-27. The synthesized compounds were screened in vitro for their antimicrobial activity and showed high to moderate activities against the tested microorganisms.

Related Products of 497-23-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 497-23-4 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry, like all the natural sciences, COA of Formula: C13H22N4O3S, begins with the direct observation of nature¡ª in this case, of matter.66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a document, author is Zhao, Guode, introduce the new discover.

The structure-based virtual screening of non-benzofuran inhibitors against M. tuberculosis Pks13-TE for anti-tuberculosis phenotypic discovery

Tuberculosis is the most infectious disease worldwide, primarily because of its increasing resistance to first-line anti-TB drugs. Therefore, development of new drugs with novel mechanisms of action is the solution to the growing problem of drug resistance. The thioesterase domain (TE) of polyketide synthase Pks13 is crucial for the biosynthesis of mycolic acids, which are the essential components of the cell wall of Mycobacterium tuberculosis. However, all the inhibitors of Pks13-TE just share the same benzofuran scaffold, which restricts the further development of Pks13-TE inhibitors. Hence, in order to search for new inhibitors with novel scaffolds and in vitro anti-tuberculosis activity, a structure-based virtual screening method was established to screen the FDA database against pks13-TE. The hit drugs were purchased and tested for anti-tubercular activity against the selectable marker-free autoluminescent Mycobacterium tuberculosis H37Ra (UAlRa). Interestingly, three old drugs approved by FDA, namely, carvedilol (32 mu g ml(-1)), celecoxib (64 mu g ml(-1)), and quinacrine (64 mu g ml(-1)) were discovered to possess in vitro anti-tubercular activity. The complexes of Pks13-TE with the hits showed a similar binding stability and interaction mode with Pks13-TE/co-crystal ligand Tam16, which were validated by the 100 ns molecular dynamics simulations, the binding free energy calculations and alanine scanning mutagenesis analysis. The rest of the chiral isomers for carvedilol and quinacrine were also researched by the same computational strategies. The results of the calculations proved that the S-configuration of carvedilol had a stronger binding affinity with Pks13-TE than the R-configuration of carvedilol, and S and R configurations of quinacrine displayed an equivalent binding affinity with the protein. As the three hit compounds have already been on the market for decades, these compounds possess good enough druggability and definite toxicity and side effects, which were consistent with the prediction results. Our work shows the successful application of computational strategies for the discovery of Pks13-TE non-benzofuran inhibitors with in vitro anti-tubercular activities. These discoveries would further promote the development of Pks13-TE inhibitors and anti-tubercular agents.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 66357-35-5. COA of Formula: C13H22N4O3S.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Sivamuthuraman, Koilpitchai,once mentioned of 497-23-4, Category: benzofurans.

Catalytic enantioselective Michael addition of 2-substituted benzofuran-3-ones to 2-enoyl pyridines

An organocatalytic diastereo- and enantioselective synthesis of 2,2 ‘-disubstituted benzofuran-3-ones bearing adjacent quaternary and tertiary stereocenters has been achieved through Michael addition of 2-substituted benzofuran-3-ones to 2-enoyl pyridines. Both the enantiomeric forms of the major diastereomer were obtained using l-proline derived squaramide and quinine derived bis squaramide with excellent yield (up to 98%) and stereoselectivities (up to 97 : 3 dr and 98% ee). The control experiment revealed that the presence and position of nitrogen atoms in the 2-enoylpyridine have played a crucial role in the stereochemical outcome of the product.

Interested yet? Keep reading other articles of 497-23-4, you can contact me at any time and look forward to more communication. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem