Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis was written by Makane, Vitthal B.;Krishna, Vagolu Siva;Krishna, Eruva Vamshi;Shukla, Manjulika;Mahizhaveni, Balakrishnan;Misra, Sunil;Chopra, Sidharth;Sriram, Dharmarajan;Azger Dusthackeer, Vijayan N.;Rode, Haridas B.. And the article was included in Future Medicinal Chemistry in 2019.Electric Literature of C10H8O3 This article mentions the following:
In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles I (R1 = Ph, 2-BrC6H4, 4-OHC6H4, etc.) as potent antitubercular agents. A small library of 2-mercapto-1,3,4-oxadiazoles I was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Compound I (R1 = 4-OHC6H4) was identified as antitubercular lead with MIC of 0.6μg/mL against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, I (R1 = 4-OHC6H4) showed antitubercular activity against pre-extensively drug-resistant clin. isolate of Mycobacterium with MIC of 2μg/mL. This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Electric Literature of C10H8O3).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C10H8O3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem