In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 54450-20-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 54450-20-3, name is 5-Bromobenzofuran-3(2H)-one. In an article，Which mentioned a new discovery about 54450-20-3
Death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) is a serine/threonine kinase that plays a key role in a wide variety of cell death signaling pathways. Inhibition of DRAK2 was found to efficiently protect islet beta-cells from apoptosis and hence DRAK2 inhibitors represent a promising therapeutic strategy for the treatment of diabetes. Only very few chemical entities targeting DRAK2 are currently known. We carried out a high throughput screening and identified compound 4 as a moderate DRAK2 inhibitor with an IC50value of 3.15 muM. Subsequent SAR studies of hit compound 4 led to the development of novel benzofuran-3(2H)-one series of DRAK2 inhibitors with improved potency and favorable selectivity profiles against 26 selected kinases. Importantly, most potent compounds 40 (IC50 = 0.33 muM) and 41 (IC50 = 0.25 muM) were found to protect islet beta-cells from apoptosis in dose-dependent manners. These data support the notion that small molecule inhibitors of DRAK2 represents a promising strategy for the treatment of diabetes.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 54450-20-3, help many people in the next few years.Recommanded Product: 54450-20-3
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3622O – PubChem