Application of 70539-42-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Shell-crosslinked knedel-like nanoparticles induce lower immunotoxicity than their non-crosslinked analogs. Author is Elsabahy, Mahmoud; Samarajeewa, Sandani; Raymond, Jeffery E.; Clark, Corrie; Wooley, Karen L..
The development of stable nanoparticles that can withstand the changing conditions experienced in a biol. setting and also be of low toxicity and immunogenicity is of particular importance to address the problems associated with currently utilized nanotechnol.-based therapeutics and diagnostics. The use of crosslinked nanoparticles continues to receive special impetus, due to their robust structure and high kinetic stability, and they have recently been shown to induce lower cytotoxicity than their non-crosslinked micellar counterparts. In the current study, poly(acrylamidoethylamine)-block-poly(D,L-lactide) (PAEA90-b-PDLLA40) copolymers were synthesized, self-assembled in water to yield nanoscopic polymeric micelles, and the effects of decorating the micellar surface with poly(ethylene glycol) (i.e. PEGylation) and crosslinking the PAEA layer to varying extents on the physicochem. characteristics, cytotoxicity and immunotoxicity of the nanoparticles were studied. Herein, we report for the first time that crosslinking can efficiently reduce the immunotoxicity of polymeric nanomaterials. In addition, increasing the degree of crosslinking further reduced the accessibility of biomols. to the core of the nanoparticles and decreased their cytotoxicity and immunotoxicity. It is also highlighted that crosslinking can be more efficient than PEGylation in reducing the immunotoxicity of nanomaterials. Shell-crosslinking of block copolymer micelles, therefore, is expected to advance their clin. development beyond the earlier known effects, and to broaden the implications in the field of nanomedicine.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem