Month: January 2023

NHC-Catalyzed Enantioselective Dearomatizing Hydroacylation of Benzofurans and Benzothiophenes for the Synthesis of Spirocycles was written by Janssen-Mueller, Daniel;Fleige, Mirco;Schluens, Danny;Wollenburg, Marco;Daniliuc, Constantin G.;Neugebauer, Johannes;Glorius, Frank. And the article was included in ACS Catalysis in 2016.Recommanded Product: 551001-79-7 This article mentions the following:

Benzofurans and benzothiophenes have been efficiently employed as substrates in an enantioselective intramol. hydroacylation. Breaking aromaticity in a 5-exo-trig cyclization of easily accessible heteroarenes by NHC-catalyzed hydroacylation gives access to a simple class of mainly unexplored spirocycles with up to 99% enantiomeric excess (ee). The formed product class bears interesting three-dimensional pseudoaxial chirality and shows typical ketone reactivity. D. functional theory (DFT) calculations reveal erosion of the ee via a stepwise mechanism bearing a hetero Wheland intermediate. Theor. data are in agreement with deuterium-labeling studies and a linear correlation between electronics (σ) and the ee. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Recommanded Product: 551001-79-7).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 551001-79-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of clenbuterol hydrochloride in pork by fluorescence spectrophotometry was written by Gao, Xianjuan. And the article was included in Zhongguo Niangzao in 2014.Application of 38183-12-9 This article mentions the following:

Clenbuterol hydrochloride in pork was determined with high fluorescent derivatives generated from fluorescamine and clenbuterol hydrochloride. Experiments showed that the maximum excitation wavelength and maximum emission wavelength of the strong fluorescent material produced by fluorescence amine and clenbuterol reaction were 500 nm and 490 nm, resp. The optimum derivative test conditions were determined by L₉ (3⁴) orthogonal experiments as follows: derivative temperature 37°C, time 40 min, and fluorescamine (1 μg/mL) addition 0.3 mL. The fluorescence signal was in good linear relation with clenbuterol hydrochloride concentration, and the linear equation was y=82492x+957.96 and the correlation coefficient was 0.9933. The method could be used in clenbuterol detection in pork. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A self-assembly pipette tip graphene solid-phase extraction coupled with liquid chromatography for the determination of three sulfonamides in environmental water was written by Sun, Ning;Han, Yehong;Yan, Hongyuan;Song, Yanxue. And the article was included in Analytica Chimica Acta in 2014.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

A sensitive, economical, and miniaturized self-assembly pipet tip graphene solid-phase extraction (PT-G-SPE) coupled with liquid chromatog. fluorescence detection (LC-FD) was developed for rapid extraction and determination of three sulfonamide antibiotics (SAs) in environmental water samples. The PT-G-SPE cartridge, assembled by packing 1.0 mg of graphene as sorbent into a 100 μL pipet tip, showed high adsorption capacity for the SAs owing to the large surface area and unique structure of graphene. The factors that affected the extraction efficiency of PT-G-SPE, including sample volume, pH, sorbent amount, washing solvent and eluent solvent were optimized. Good linearity for SAs was obtained in a range of 2-4000 pg mL^-1 with correlation coefficients (r²) ≥0.9993. The recoveries of the SAs at three spiked levels ranged from 90.4 to 108.2% with RSD ≤6.3%. In comparison with other sorbents such as C₁₈, HLB, SCX, PCX, and multiwalled carbon nanotubes, one advantage of using graphene as sorbent of pipet tip solid-phase extraction (PT-SPE) was that PT-G-SPE could adsorb larger sample volume (10 mL) at a small amount of sorbent (1 mg) and low solvent consumption with good extraction efficiency, which not only increased the fraction of analytes to LC and the sensitivity of SAs determination, but also reduced the cost and pollution. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A review on the use of fluorescamine as versatile and convenient analytical probe was written by Derayea, Sayed M.;Samir, Ebtihal. And the article was included in Microchemical Journal in 2020.COA of Formula: C17H10O4 This article mentions the following:

Fluorescamine (FSA) has been widely applied for the determination of several classes of compounds containing amino groups. The estimated substances included pharmaceutical compounds, pesticides, amino acids, peptides and proteins. In addition, the activities of some enzymes were also monitored by FSA assay. The employed techniques mainly included spectrofluorimetry, as spray reagent in TLC, a derivativzation reagent in HPLC and capillary electrophoresis. Although there are many other reagents for detecting primary amino group containing compounds, FSA is advantageous as the reagent itself and its hydrolytic product are non-fluorescent. While other reagents such as NBD-Cl, dansyl chloride and o-phthaldehyde have a native fluorescence and their hydrolytic products are indeed fluorescent. In addition, the involved reaction is very fast and carried out at ambient temperature However, the sensitivity of FSA anal. is much lower than these reagents. The sensitivity of the reagent could be enhanced by the proper selection of the diluting solvent, addition of surfactants or extraction with water immiscible solvent. The present article represents a comprehensive review for the application of FSA as a reagent in chem. and biochem. anal. since its discovery until now. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of eleven sulfonamides residues in animal foods by high performance liquid chromatography-fluorescence detection after matrix solid phase dispersion extraction was written by Yang, Xiaosong;Yu, Huiju;Qiu, Sha;Sun, Chengjun. And the article was included in Zhongguo Weisheng Jianyan Zazhi in 2013.Application of 38183-12-9 This article mentions the following:

A method for simultaneous determination of eleven sulfonamide residues (SAs), including sulfisomidine, sulfapyridine, sulfadimidin, sulfamoxol, sulfamonomethoxine, sulfamethizol, sulfachloyopyridazine, sulfasoxine, sulfamethoxazole, sulfisoxazole, and sulfabeuzamide, in animal foods by high-performance liquid chromatog. (HPLC) with fluorescence detection using matrix solid-phase dispersion (MSPD) extraction was presented. Animal food sample was crushed and well-distributed with the solid-phase sorbents C₁₈, and then the mixture was loaded in a vacant SPE cartridge, covered with a piece of filter paper on the top of the mixture, rinsed with hexane to remove fat, eluted with 3:1 (volume/volume) Et acetate-dichloromethane solvent to elute the analytes, then the eluant was dried up at 40°C under N₂, and finally the residue was re-dissolved with 1.0 mL 1:1 (volume/volume) methanol-0.2% acetic acid, fluorescamine was added to produce fluorescent derivatives The derivatives were determined by HPLC with fluorescence detection, using an Agilent TC-C₁₈ column and a mixture of 0.2% acetic acid solution-acetonitrile as the mobile phase for gradient elution and detected with a fluorescence detector. The linear ranges of eleven sulfonamides were between 0.02 mg/ to 0.40 mg/L with r>0.999. The detection limits were 0.001 mg/L. The min. detectable content was 0.006 mg/kg. The recovery range was between 54% and 105% with relative standard deviations from 1.3% to 6.1%. The method has the advantages of a small amount of organic solvent, short time of anal., high sensitivity, and low detection limit. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enhancing intersystem crossing to achieve thermally activated delayed fluorescence in a water-soluble fluorescein derivative with a flexible propenyl group was written by Wu, Yingnan;Zhao, Yanliang;Zhou, Panwang;Zheng, Daoyuan;Wang, Honglei;Tang, Shanliang;Tian, Jiarui;Yang, Songqiu;Deng, Weiqiao;Han, Keli;Song, Fengling. And the article was included in Journal of Physical Chemistry Letters in 2020.Reference of 76-54-0 This article mentions the following:

It is a challenge to rationally design an organic mol. with thermally activated delayed fluorescence (TADF) due to the intrinsically spin-forbidden transition. Meanwhile, those reported TADF organic mols. have difficulty to be directly applied in the field of biol. and medical imaging because they usually have no water solubility Here, a water-soluble TADF organic mol. DCF-BXJ was developed by introducing a flexible propenyl group into the com. traditional fluorophore DCF (2,7-dichlorofluorescein). The flexible group provides nonradiative rotational motion, which causes an efficient energy level cross between the S₁ state and the T₂ state of DCF-BXJ. Results of transient absorption spectra and theor. calculations supported that nonradiative rotational motion of the flexible group can enhance intersystem crossing (ISC) and bring out TADF. This work provides a new mechanism explanation for TADF existing in organic mols. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-Water Synthesis of Quinazolinones from 1,1-Dichloro-2-nitroethene and Anthranilamides was written by Zhu, Fengjuan;Song, Runjiang;Li, Shen;Shao, Xusheng. And the article was included in Synlett in 2016.Category: benzofurans This article mentions the following:

An efficient synthetic methodol. was developed for direct formation of quinazolinones with 2-nitromethyl substituent via 1,1-dichloro-2-nitroethene and anthranilamides. This strategy provides an alternative for quinazolinones construction with merits of proceeding in water, easy purification, and no addition of catalysts. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Category: benzofurans).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The antimicrobial mechanism of Greek thyme honeys against methicillin-resistant Staphylococcus aureus clinical isolates: a case study of comparison with Manuka honey was written by Masoura, Maria;Gkatzionis, Konstantinos. And the article was included in International Journal of Food Science and Technology in 2022.Recommanded Product: 76-54-0 This article mentions the following:

The antibacterial potential of honey has been of great scientific interest. Understanding the underlying mechanism is essential to explore its potential as therapeutic alternative against a range of (non)pathogenic microorganisms. The floral origin of honey is critical for its antibacterial activity and Greek thyme honeys have been of increasing interest due to their chem. composition and bioactivity. In this study, the antimicrobial effect of six Greek honeys, with different percentages of thyme pollen grains and two Manuka honeys were tested against four MRSA clin. isolates (ATCC 43300, 0791, 28965, 01322). Agar-well diffusion assay and total viable counts were used to examine the antimicrobial strength of honeys, while the effect thereof on cellular redox state and cell membrane was tested by flow cytometry. Thyme honeys had superior or equal antimicrobial strength compared to this of Manuka, while thermal processing did not significantly affect this activity. Acidity and the high H₂O₂ content, common features for all thyme honeys, caused cellular oxidative damage and cell death unlike observed in Manuka-treated populations. The activity of the monofloral thyme honey (74% thyme pollen) was higher than the other indigenous polyfloral samples, which confirms the medicinal importance of this medicinal plant. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Recommanded Product: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors was written by Rodrigues, Daniel A.;Guerra, Fabiana S.;Sagrillo, Fernanda S.;Pinheiro, Pedro de Sena M.;Alves, Marina A.;Thota, Sreekanth;Chaves, Lorrane S.;Sant’Anna, Carlos M. R.;Fernandes, Patricia D.;Fraga, Carlos A. M.. And the article was included in ChemMedChem in 2020.Application In Synthesis of Methyl benzofuran-2-carboxylate This article mentions the following:

Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacol. profile, and mol. modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application In Synthesis of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application In Synthesis of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biocompatible N-acetyl-nanoconstruct alleviates lipopolysaccharide-induced acute lung injury in vivo was written by Kim, Seongchan;Kim, Shin Young;Rho, Seung Joon;Kim, Seung Hoon;Song, So Hyang;Kim, Chi Hong;Lee, Hyojin;Kim, Sung Kyoung. And the article was included in Scientific Reports in 2021.Related Products of 76-54-0 This article mentions the following:

Oxidative stress plays important roles in inflammatory responses during acute lung injury (ALI). Recently, nanoconstruct (Nano)-based drug-delivery systems have shown promise in many models of inflammation. In this study, we evaluated the anti-inflammatory effects of N-acetylcysteine (NAC) loaded in a biocompatible Nano using a rat model of ALI. We synthesized a Nano with a good NAC-releasing capacity using porous silica Nano, which was used to produce Nano/NAC complexes. For in vivo experiments, Sprague-Dawley rats were i.p. administered NAC or Nano/NAC 30 min after intratracheal instillation of lipopolysaccharide. After 6 h, bronchoalveolar lavage fluids and lung tissues were collected. The anti-oxidative effect of the Nano/NAC complex was confirmed by demonstrating reduced levels of reactive oxygen species after treatment with the Nano/NAC in vitro. In vivo experiments also showed that the Nano/NAC treatment may protect against LPS-induced ALI thorough anti-oxidative and anti-inflammatory effects, which may be attributed to the inactivation of the NF-κB and MAPK pathways. In addition, the effects of Nano/NAC treatment were shown to be superior to those of NAC alone. We suggest the therapeutic potential of Nano/NAC treatment as an anti-inflammatory agent against ALI. Furthermore, our study can provide basic data for developing nanotechnol.-based pharmacotherapeutics for ALI. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem