Yamagami, Chisako et al. published their research in Chemical & Pharmaceutical Bulletin in 1992 | CAS: 1646-27-1

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C10H8O3

Hydrophobicity parameters determined by reversed-phase liquid chromatography. V. Relationship between the capacity factor and the octanol-water partition coefficient for simple heteroaromatic compounds and their ester derivatives was written by Yamagami, Chisako;Takao, Narao. And the article was included in Chemical & Pharmaceutical Bulletin in 1992.COA of Formula: C10H8O3 This article mentions the following:

The log k‘ (k‘: capacity factor) values of various heteroaromatic compounds were measured by reversed-phase high-performance liquid chromatog. (RPLC) using a Capcell pack C18 column and methanol-water eluents, and the relation with log P values (P: 1-octanol-water partition coefficient) was examined as a function of the mobile phase composition Furans having nonhydrogen-bonding or weakly hydrogen-accepting substituents exhibited a good linear relation at 50% MeOH concentration Amphiprotic substituents, CONHR, showed an acceleration effect (less retained than nonhydrogen-bonders and hydrogen-acceptors under the condition of equivalent log P), as is often observed in heterocyclic systems. The relation was more complicated at other methanol contents, due to different retention behavior demonstrated by the ester-type substituents, CO2R and CONR2 (ester effect). To gain more insight into this ester effect, the retention behavior of ester derivatives of various heteroaromatics such as furan, benzofuran, N-methylpyrrole and indole was also studied. The factors affecting the log P-log k‘ relation were discussed, and the optimum RPLC condition for predicting the log P value was described. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem