Recently I am researching about ACETYLCHOLINESTERASE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973235, 21977102]; Guangdong Basic and Applied Basic Research Foundation [2019B151502042]; Key-Area Research and Development Program of Guangdong Province [2020B1111030005]; Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province [[2019]A28, [2020]033, [2020]037, [2020]039]; Guangdong Local Innovation Team Program [2019BT02Y262]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Liao Ning Revitalization Talents Program [XLYC1802037]. Published in MDPI in BASEL ,Authors: Dai, Y; Li, KL; She, JL; Zeng, YB; Wang, H; Liao, SR; Lin, XP; Yang, B; Wang, JF; Tao, HM; Dai, HF; Zhou, XF; Liu, YH. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. HPLC of Formula: C8H6O2
A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem