Tag: M.W=200-250

Jasmansyah published the artcileAntibacterial constituents from Morus macroura, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Research Journal of Chemistry and Environment (2019), 23(11), 37-40, database is CAplus.

Morus macroura Miq. is the only Morus plant species found in West Sumatera of Indonesia. Our previous phytochem. studies have isolated two stilbene dimers from the woods and root trunks of the plant. In this study we report six phenolic compounds, namely Me 2,4-dihydroxy-3,6-dimethylbenzoate (1), norarto-carpanone (2), moracins M (3) and B (4), mulberroside C (5) and mulberrofuran K (6) from the tree barks of this plant. Structures of these compounds were determined based on NMR and mass spectral data. On antibacterial evaluation, compound 7 showed significant antibacterials against gram-(+) bacteria Bacilus subtilis and Staphylococcus aureus.

Research Journal of Chemistry and Environment published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Liu, Zhihua published the artcile2-Arylbenzofurans from the leaves of oriental tobacco and their cytotoxicity, Computed Properties of 56317-21-6, the publication is Asian Journal of Chemistry (2013), 25(15), 8278-8280, database is CAplus.

Four types of 2-arylbenzofurans (1-4), including a new compound, tobarylbenzofuran A (1), were isolated from the leaves of oriental tobacco (a variety of Nicotiana tabacum L). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The two compounds were tested for their cytotoxicity against five human tumors (NB4, A549, SHSY5Y, PC3, and MCF7) cell lines. The results showed that compound 1 showed notable inhibitory effect against SHSY5Y and MCF7 cell lines, with IC₅₀ values of 3.5 and 1.8 μM, resp.

Asian Journal of Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Computed Properties of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fu, Zhengjiang published the artcileTransition metal-free electrocatalytic halodeborylation of arylboronic acids with metal halides MX (X = I, Br) to synthesize aryl halides, Application of 2-Iodobenzofuran, the publication is Organic Chemistry Frontiers (2020), 7(3), 590-595, database is CAplus.

An efficient and regioselective ipso-halogenation of diverse arylboronic acids RB(OH)₂ (R = 4-chlorophenyl, 2,4-dimethoxyphenyl, 1-benzofuran-2-yl, etc.) with sodium halide salts NaX (X = I, Br) to synthesize aryl halides RX has been well established under electrochem. conditions. A gram-scale reaction has been performed to evaluate the applicability of the protocol. Cyclic voltammetry experiments indicated that the halide anion was oxidized prior to the 4-methoxyphenylboronic acid substrate under standard conditions.

Organic Chemistry Frontiers published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Application of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Naik, Ravi published the artcileBioactive benzofuran derivatives: Moracins A-Z in medicinal chemistry, Computed Properties of 56317-21-6, the publication is European Journal of Medicinal Chemistry (2015), 379-393, database is CAplus and MEDLINE.

A review. Benzofuran heterocycles are fundamental structural units in a variety of biol. active natural products as well as synthetic materials. Over the time, benzofuran derivatives have attracted many researchers due to the broad scope of their biol. activity, which include anticancer, antimicrobial, immunomodulatory, antioxidant and anti-inflammatory properties. Egonol, homoegonol and moracin families are biol. active natural products containing benzofuran heterocycle as basic structural units. This paper focuses on the moracin family (moracin A to Z). Morus, a genus of flowering plants in the family Moraceae, comprises 10-16 species of deciduous trees commonly known as mulberries. The root bark, stem bark and leaves of Morus alba, M. lhou, Morus macroura are the main sources for arylbenzofuran derivatives including the moracins. A large volume of research has been carried out on moracins and their derivatives, which has shown the pharmacol. importance of this benzofuran heterocyclic nucleus. In this mini-review, we attempt to highlight the importance of moracins, as they have been a major source for drug development. Herein, the authors also summarize the current state of the art concerning the synthesis and medicinal use of moracins A-Z.

European Journal of Medicinal Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Computed Properties of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Sivaraman, Aneesh published the artcileA protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans, Category: benzofurans, the publication is Organic & Biomolecular Chemistry (2019), 17(8), 2153-2161, database is CAplus and MEDLINE.

The first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans was reported. The present protocol provided shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.

Organic & Biomolecular Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C28H41N2P, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Partridge, Benjamin M. published the artcileSterically controlled iodination of arenes via iridium-catalyzed C-H borylation, SDS of cas: 69626-75-1, the publication is Organic Letters (2013), 15(1), 140-143, database is CAplus and MEDLINE.

A mild method to prepare aryl and heteroaryl iodides by sequential C-H borylation and iodination is reported. The regioselectivity of this process is controlled by steric effects on the C-H borylation step and is complementary to existing methods to form aryl iodides. The iodination of boronic esters has potential for the synthesis of radiolabeled aryl iodides, as demonstrated by the concise synthesis of a potential tracer for SPECT imaging.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, SDS of cas: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Usui, Shinya published the artcileDirect ortho Cupration: A New Route to Regioselectively Functionalized Aromatics, COA of Formula: C8H5IO, the publication is Journal of the American Chemical Society (2007), 129(49), 15102-15103, database is CAplus and MEDLINE.

The authors have developed a direct regio- and chemoselective method for generating functionalized aromatic cuprate compounds through deprotonative directed ortho cupration using TMP(tetramethylpiperidino)-cuprates (R(TMP)Cu(CN)Li₂; R = alkyl, Ph, or TMP) that were prepared by mixing of CuCN, RLi, and Li tetramethylpiperidide (LTMP) in THF. Deprotonative cupration of various functionalized benzenes with TMP-cuprate proved effective for the direct generation of o-functionalized Cu aromatic and heteroaromatic derivatives, particularly those with electrophilic functional groups, such as cyano, amide, and halogens. Direct cupration, followed by electrophilic trapping, provided a convenient preparative method for 1,2- or 1,2,3-multisubstituted aromatic compounds, e.g. 95 % 2-iodo-1,3-dimethoxybenzene from 1,3-dimethoxybenzene. The functionalized aromatic cuprate intermediates also undergo oxidation reactions very efficiently and with high regio- and chemoselectivity to afford functionalized phenol, ligand(hetero)-coupling, or homocoupling products by appropriately changing the oxidants and cuprates. The crystal and mol. structures of (TMP)₂Cu(CN)Li₂THF were determined by x-ray crystallog.

Journal of the American Chemical Society published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C15H24O2, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Chen, Kai published the artcileSynthesis of aryl trimethylstannanes from aryl halides: an efficient photochemical method, Computed Properties of 69626-75-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(58), 9125-9128, database is CAplus and MEDLINE.

An efficient transition-metal-free photochem. method featuring excellent functional group tolerance, mild reaction conditions and short reaction times has been discovered and developed for the synthesis of (hetero)aryl trimethylstannanes from (hetero)aryl halides. A photo-initiated radical chain mechanism was proposed based on preliminary mechanistic studies.

Chemical Communications (Cambridge, United Kingdom) published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Sun, Jian published the artcileAntioxidant and nitrite-scavenging capacities of phenolic compounds from sugarcane (Saccharum officinarum L.) tops, Product Details of C14H10O4, the publication is Molecules (2014), 19(9), 13147-13160, 14 pp., database is CAplus and MEDLINE.

Sugarcane tops were extracted with 50% ethanol and fractionated by petroleum ether, Et acetate (EtOAc), and Bu alc. successively. Eight phenolic compounds in EtOAc extracts were purified through silica gel and Sephadex LH-20 column chromatogs., and then identified by NMR and electrospray ionization mass spectra. The results showed that eight phenolic compounds from EtOAc extracts were identified as caffeic acid, cis-p-hydroxycinnamic acid, quercetin, apigenin, albanin A, australone A, moracin M, and 5′-geranyl-5,7,2′,4′-tetrahydroxyflavone. The antioxidant and nitrite-scavenging capacities of different solvent extracts correlated pos. with their total phenolic (TP) contents. Amongst various extracts, EtOAc extracts possessed the highest TP content and presented the strongest oxygen radical absorbance capacity (ORAC), 1,1′-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging capacity, 2,2′-azobis-3-ethylbenthiaazoline-6-sulfonic acid (ABTS) radical-scavenging capacity, ferric reducing antioxidant power (FRAP) and nitrite-scavenging capacity. Thus, sugarcane tops could be promoted as a source of natural antioxidant.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C9H7NO2, Product Details of C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kim, Ji Yeon published the artcileChemical profiles and hypoglycemic activities of mulberry leaf extracts vary with ethanol concentration, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Food Science and Biotechnology (2013), 22(5), 1-5, database is CAplus.

Five mulberry leaf extracts (water, 25, 50, 75, and 100% EtOH) were characterized for in vitro hypoglycemic activity and chem. profiles. According to chem. profiles obtained from ¹⁵Tesla Fourier transform ion cyclotron resonance mass spectrometry, water extracts contained more 1-deoxynojirimycin (DNJ) and fewer phytochems. than other extracts However, water extracts showed the highest inhibitory activity of glucose uptake. The degree of inhibition of α-glucosidase activity was similar for all extracts The effect of mulberry leaf extracts on the glucose metabolism may be attributed to addnl. or cooperative effects of DNJ with other phytochem. compounds

Food Science and Biotechnology published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem