Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for β-amyloid plaques was written by Swahn, Britt-Marie;Wensbo, David;Sandell, Johan;Sohn, Daniel;Slivo, Can;Pyring, David;Malmstroem, Jonas;Arzel, Erwan;Vallin, Michaela;Bergh, Margareta;Jeppsson, Fredrik;Johnson, Allan E.;Jureus, Anders;Neelissen, Jan;Svensson, Samuel. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Formula: C9H9BO4 This article mentions the following:
The syntheses and SAR of new series of β-amyloid binding agents are reported. The effort to optimize signal-to-background ratios for these ligands are described. Compounds I (X = S, O) and II displayed desirable lipophilicity and pharmacokinetic properties. Compounds I (X = S, O) were evaluated with in vitro autoradiog. studies and in vivo in APP/PS1 transgenic mice. It is shown that it was possible to increase the signal-to-background ratios compared to PIB 1, as demonstrated by compounds I (X = S, O). In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Formula: C9H9BO4).
(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C9H9BO4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem