Owen, Caroline P. et al. published their research in Journal of Pharmacy and Pharmacology in 1999 | CAS: 1646-27-1

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 1646-27-1

Inhibition of aromatase (P450Arom) by some 1-(benzofuran-2-ylmethyl)imidazoles was written by Owen, Caroline P.;Nicholls, Paul J.;Smith, H. John;Whomsley, Rhys. And the article was included in Journal of Pharmacy and Pharmacology in 1999.Related Products of 1646-27-1 This article mentions the following:

Studies of a series of 1-(benzofuran-2-ylmethyl)imidazoles, 1-5, previously proposed as potential agents for prostatic cancer by their inhibition of 17β-hydroxylase: 17,20-lyase (P 450 17), have been extended to their selectivity against placental microsomal aromatase (P 450Arom) in man. The compounds were 3-7-fold more potent than aminoglutethimide and had some selectivity for P 450 17 as expressed by the ratio (IC50 P 450Arom)/(IC50 P 450) 17/17.0 (2), 10.3 (3), 34.6 (4) and 42.0 (5), where IC50 is the concentration resulting in 50% inhibition. The lower potency of 1-5 towards P 450Arom compared with the racemic α-phenyl-substituted compounds (6, 80-1000 × aminoglutethimide) and some racemic α-Me (8.5 and 12.2 × aminoglutethimide) and α-Et (12.1 and 32.9 × aminoglutethimide) analogs has been rationalized. This work selectively extends studies of the P 450 17 inhibitor 5, a potential prostatic cancer agent, towards other cytochrome P 450 enzymes in the steroidogenic pathway and provides a general method for determining the relative influence of chem. manipulation of a parent inhibitor towards two enzymes in the pathway using addnl. literature data. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Related Products of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem