Fitzgerald, T. J.; Williams, Betsy; Uyeki, E. M. published the article 《Antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice》. Keywords: antimitotic paw swelling; antiinflammatory agent edema; colchicine antimitotic.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).COA of Formula: C19H19N2NaO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.
The antimitotics colchicine (I) [64-86-8] (2 mg/kg), vinblastin [865-21-4] (8 mg/kg), vincristine [57-22-7] (1 mg/kg), and podophyllotoxin [518-28-5] (2 or 10 mg/kg) produced in mice a significant suppression of paw swelling at similar dose levels. Deacetamidocolchicine [1420-08-2], a more potent antimitotic agent than I, was less active against paw swelling even when given in a 58-fold greater dose. The antiinflammatory agents prednisone [53-03-2] (12 mg/kg) and indomethacin [53-86-1] (20 mg/kg) inhibited paw swelling but phenylbutazone [50-33-9] (250 mg/kg), even at lethal doses, was inactive in this respect.
《Antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)COA of Formula: C19H19N2NaO2.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem