With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.
Next, 0.75 g (2.0 mmol) of the compound of the structural formula (3), 0.64 g (3.0 mmol) of 3-bromophthalide and 10 ml of acetonitrile were placed in a 100 ml recovery flask, and the mixture was stirred at 70 C. for 6 hours under a nitrogen stream went. After completion of the reaction, the precipitated crystals were filtered and washed with acetonitrile to obtain 0.83 g (yield: 70%) of halide (I, Br mixed) of exemplified compound A-4. Next, an aqueous solution of 0.41 g (2.5 mmol) of ammonium hexafluorophosphate was added dropwise to an aqueous solution of 0.5 g (0.84 mmol) of the halogen compound of exemplified compound A-4 and stirred for 2 hours. After completion of the reaction, the precipitated white crystals were filtered, washed with water and dried at room temperature under reduced pressure to obtain 0.40 g (yield 70%) of exemplified compound A-4., 6940-49-4
6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; CANON INCORPORATED; TAMURA, TETSUYA; IGAWA, SATOSHI; YAMADA, KENJI; (27 pag.)JP2017/197477; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem