Why do aromatic interactions matter of compound: 70539-42-3

I hope my short article helps more people learn about this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Synthetic Route of C18H20N2O12. Apart from the compound(70539-42-3), you can read my other articles to know other related compounds.

Iwuoha, Emmanuel I.; Leister, Ingrid; Miland, Enda; Smyth, Malcolm R.; Fagain, Ciaran O. published an article about the compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3,SMILESS:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O ).Synthetic Route of C18H20N2O12. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70539-42-3) through the article.

Amperometric organic- and aqueous-phase peroxide biosensors were prepared with native and N-hydroxysuccinimide ester (NHS)-modified horseradish peroxidase (HRP). The ε-amino functions of the six free lysine residues of HRP were selectively modified with homobifunctional suberic acid bis(N-hydroxysuccinimide ester) (SA-NHS) or ethylene glycol bis(succinic acid N-hydroxysuccinimide ester) (EG-NHS). The biosensors were based on electrostatic complexation of the HRP variants with an osmium bis(bipyridyl)poly(4-vinylpyridine) polymer. The enzyme electrodes were operated in both aqueous (0.1 M phosphate buffer, pH 7.0) and organic (90% CH3CN) phases, for the detection of hydrogen peroxide and Me isothiocyanate. Kinetic anal. of the steady-state amperometry data showed that chem. modification of HRP about up to a ∼5-fold enhancement of the biosensor sensitivity for H2O2 and an improvement in both sensor stability and organotolerance. Also, NHS modification of HRP results in a 3-fold extension of the range of linear response of the peroxide sensor in both aqueous and nonaqueous media. When used as a Me isothiocyanate sensor in the organic phase, the amperometric responses of the biosensors were doubled on changing from native HRP to NHS-HRP electrodes.

I hope my short article helps more people learn about this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Synthetic Route of C18H20N2O12. Apart from the compound(70539-42-3), you can read my other articles to know other related compounds.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem