Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3. In an article, author is Oschmann, Michael,once mentioned of 174775-48-5, SDS of cas: 174775-48-5.
Synthesis of Elaborate Benzofuran-2-Carboxamide Derivatives through a Combination of 8-Aminoquinoline Directed C-H Arylation and Transamidation Chemistry
Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C-H arylation and transamidation chemistry, and which enables access to a wide range of elaborate benzofuran-2-carboxamides. For the directed C-H arylation reactions, Pd catalysis was used to install a wide range of aryl and heteroaryl substituents at the C3 position of the benzofuran scaffold in high efficiency. Directing group cleavage and further diversification of the C3-arylated benzofuran products were then achieved in a single synthetic operation through the utilization of a one-pot, two-step transamidation procedure, which proceeded via the intermediate N-acyl-Boc-carbamates. Given the high efficiency and modularity of this synthetic strategy, it constitutes a very attractive method for generating structurally diverse collections of benzofuran derivatives for small molecule screening campaigns.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem